Inactivation of the β(1,2)-xylosyltransferase and the α(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 Cells by a Multiplex CRISPR/Cas9 Strategy Results in Glycoproteins without Plant-Specific Glycans

Establishment of a tobacco BY2 cell line devoid of plant-specific xylose and fucose as a platform for the production of biotherapeutic proteins

(2017) Uri Hanania et al.   PLANT BIOTECHNOLOGY JOURNAL

N-Glycosylation of an IgG antibody secreted by Nicotiana tabacum BY-2 cells can be modulated through co-expression of human β-1,4-galactosyltransferase

(2017) Catherine Navarre et al.   TRANSGENIC RESEARCH

Advances in recombinant antibody manufacturing

(2016) Renate Kunert et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Reduced paucimannosidicN-glycan formation by suppression of a specific β-hexosaminidase fromNicotiana benthamiana

(2016) Yun-Ji Shin et al.   PLANT BIOTECHNOLOGY JOURNAL

Gene Inactivation by CRISPR-Cas9 in Nicotiana tabacum BY-2 Suspension Cells

(2016) Sébastien Mercx et al.   Frontiers in Plant Science

5′ and 3′ Untranslated Regions Strongly Enhance Performance of Geminiviral Replicons in Nicotiana benthamiana Leaves

(2016) Andrew G. Diamos et al.   Frontiers in Plant Science

Putting the Spotlight Back on Plant Suspension Cultures

(2016) Rita B. Santos et al.   Frontiers in Plant Science

Plants as Factories for Human Pharmaceuticals: Applications and Challenges

(2015) Jian Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiplexed, targeted gene editing inNicotiana benthamianafor glyco-engineering and monoclonal antibody production

(2015) Jin Li et al.   PLANT BIOTECHNOLOGY JOURNAL

Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system

(2015) Kabin Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taliglucerase alfa: An enzyme replacement therapy using plant cell expression technology

(2014) Gregory A. Grabowski et al.   MOLECULAR GENETICS AND METABOLISM

Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines

(2014) Brian J. Ward et al.   VACCINE

Plant Genome Engineering with Sequence-Specific Nucleases

(2013) Daniel F. Voytas   Annual Review of Plant Biology

Recent advances on host plants and expression cassettes' structure and function in plant molecular pharming

(2013) Abdullah Makhzoum et al.   BIODRUGS

N-Glycosylation of Plant-produced Recombinant Proteins

(2013) Dirk Bosch et al.   CURRENT PHARMACEUTICAL DESIGN

Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9

(2013) Jian-Feng Li et al.   NATURE BIOTECHNOLOGY

Accumulation of secreted antibodies in plant cell cultures varies according to the isotype, host species and culture conditions

(2013) Bertrand Magy et al.   PLANT BIOTECHNOLOGY JOURNAL

Optimization of BY-2 cell suspension culture medium for the production of a human antibody using a combination of fractional factorial designs and the response surface method

(2013) Nikolay Vasilev et al.   PLANT BIOTECHNOLOGY JOURNAL

Production of recombinant human granulocyte macrophage-colony stimulating factor in rice cell suspension culture with a human-like N-glycan structure

(2011) Yun-Ji Shin et al.   PLANT BIOTECHNOLOGY JOURNAL

Generation of glyco-engineered BY2 cell lines with decreased expression of plant-specific glycoepitopes

(2011) Bo-jiao Yin et al.   Protein & Cell

Improved Virus Neutralization by Plant-produced Anti-HIV Antibodies with a Homogeneous β1,4-GalactosylatedN-Glycan Profile

(2009) Richard Strasser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulated expression of plant-specific glycoepitopes in alfalfa

(2008) Christophe Sourrouille et al.   PLANT BIOTECHNOLOGY JOURNAL

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL