标题
Advances in recombinant antibody manufacturing
作者
关键词
Chinese hamster ovary (CHO), Human embryonic kidney (HEK), NS0, PER.C6, Monoclonal antibody (mAb) manufacturing, Mammalian expression systems, Process advances, Optimization strategies
出版物
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 100, Issue 8, Pages 3451-3461
出版商
Springer Nature
发表日期
2016-03-03
DOI
10.1007/s00253-016-7388-9
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Benchmarking of commercially available CHO cell culture media for antibody production
- (2015) David Reinhart et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Human cell lines for biopharmaceutical manufacturing: history, status, and future perspectives
- (2015) Jennifer Dumont et al. CRITICAL REVIEWS IN BIOTECHNOLOGY
- Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture
- (2015) Shohei Kishishita et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- Capillary ion-exchange chromatography with nanogram sensitivity for the analysis of monoclonal antibodies
- (2015) Jennifer C. Rea et al. JOURNAL OF CHROMATOGRAPHY A
- Heterologous protein production using euchromatin-containing expression vectors in mammalian cells
- (2015) Katalin Zboray et al. NUCLEIC ACIDS RESEARCH
- Microchip Zone Electrophoresis for High-Throughput Analysis of Monoclonal Antibody Charge Variants
- (2014) Tobias D. Wheeler et al. ANALYTICAL CHEMISTRY
- Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation
- (2014) Yuzhou Fan et al. BIOTECHNOLOGY AND BIOENGINEERING
- Pichia pastorissecretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space-time yields for less complex proteins
- (2014) Andreas Maccani et al. Biotechnology Journal
- Direct analysis of mAb aggregates in mammalian cell culture supernatant
- (2014) Albert J Paul et al. BMC BIOTECHNOLOGY
- Diversity in structure and functions of antibody sialylation in the Fc
- (2014) T Shantha Raju et al. CURRENT OPINION IN BIOTECHNOLOGY
- Therapeutic monoclonal antibodies and consistent ends: terminal heterogeneity, detection, and impact on quality
- (2014) Kurt Brorson et al. CURRENT OPINION IN BIOTECHNOLOGY
- Highly linear pH gradients for analyzing monoclonal antibody charge heterogeneity in the alkaline range: Validation of the method parameters
- (2014) Nico Lingg et al. JOURNAL OF CHROMATOGRAPHY A
- Structural Characterization of IgG1 mAb Aggregates and Particles Generated Under Various Stress Conditions
- (2014) Srivalli N. Telikepalli et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications
- (2014) Mark Haverick et al. mAbs
- Russell body phenotype is preferentially induced by IgG mAb clones with high intrinsic condensation propensity: Relations between the biosynthetic events in the ER and solution behaviors in vitro
- (2014) Haruki Hasegawa et al. mAbs
- Assessment of chemical modifications of sites in the CDRs of recombinant antibodies
- (2014) Markus Haberger et al. mAbs
- Very high density of Chinese hamster ovary cells in perfusion by alternating tangential flow or tangential flow filtration in WAVE bioreactor™-part II: Applications for antibody production and cryopreservation
- (2013) Marie-Françoise Clincke et al. BIOTECHNOLOGY PROGRESS
- A novel approach for using dielectric spectroscopy to predict viable cell volume (VCV) in early process development
- (2013) Brandon J. Downey et al. BIOTECHNOLOGY PROGRESS
- High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells
- (2013) Volker Jäger et al. BMC BIOTECHNOLOGY
- IgG-Fc N-glycosylation at Asn297 and IgA O-glycosylation in the hinge region in health and disease
- (2013) Jing Xue et al. GLYCOCONJUGATE JOURNAL
- CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion
- (2013) Valérie Le Fourn et al. METABOLIC ENGINEERING
- Recent advances in recombinant protein production
- (2013) Renate Kunert et al. Bioengineered
- The secrets of the Bcl-2 family
- (2012) A J García-Sáez CELL DEATH AND DIFFERENTIATION
- Differences in the glycosylation of recombinant proteins expressed in HEK and CHO cells
- (2012) Amelie Croset et al. JOURNAL OF BIOTECHNOLOGY
- Human IgG Fc-glycosylation profiling reveals associations with age, sex, female sex hormones and thyroid cancer
- (2012) Guoqiang Chen et al. Journal of Proteomics
- Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells
- (2012) Sophie Nallet et al. New Biotechnology
- Computational approach for understanding and improving GS-NS0 antibody production under hyperosmotic conditions
- (2011) Yingswan Ho et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- Effect of inducible co-overexpression of protein disulfide isomerase and endoplasmic reticulum oxidoreductase on the specific antibody productivity of recombinant Chinese hamster ovary cells
- (2010) Chaya Mohan et al. BIOTECHNOLOGY AND BIOENGINEERING
- Generation of stable cell clones expressing mixtures of human antibodies
- (2010) John de Kruif et al. BIOTECHNOLOGY AND BIOENGINEERING
- Rapid characterization and quality control of complex cell culture media solutions using raman spectroscopy and chemometrics
- (2010) Boyan Li et al. BIOTECHNOLOGY AND BIOENGINEERING
- A single-use purification process for the production of a monoclonal antibody produced in a PER.C6 human cell line
- (2010) Michael Kuczewski et al. Biotechnology Journal
- Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells
- (2010) Xiaowei Zhang et al. BIOTECHNOLOGY LETTERS
- Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment
- (2010) Yao-Ming Huang et al. BIOTECHNOLOGY PROGRESS
- Industrialization of mAb production technology: The bioprocessing industry at a crossroads
- (2010) Brian Kelley mAbs
- Assessing monoclonal antibody product quality attribute criticality through clinical studies
- (2010) Andrew M. Goetze et al. mAbs
- Cell culture processes for monoclonal antibody production
- (2010) Feng Li et al. mAbs
- Simple high-cell density fed-batch technique for high-level recombinant protein production with Pichia pastoris: Application to intracellular production of Hepatitis B surface antigen
- (2009) Chandrasekhar Gurramkonda et al. Microbial Cell Factories
- Glycosylation as a strategy to improve antibody-based therapeutics
- (2009) Roy Jefferis NATURE REVIEWS DRUG DISCOVERY
- Terminal sugars of Fc glycans influence antibody effector functions of IgGs
- (2008) T Shantha Raju CURRENT OPINION IN IMMUNOLOGY
- A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior
- (2007) Cynthia Quan et al. ANALYTICAL BIOCHEMISTRY
- Heterogeneity of Monoclonal Antibodies
- (2007) Hongcheng Liu et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Effect of Increased Expression of Protein Disulfide Isomerase and Heavy Chain Binding Protein on Antibody Secretion in a Recombinant CHO Cell Line
- (2005) Nicole Borth et al. BIOTECHNOLOGY PROGRESS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now