Review
Biochemistry & Molecular Biology
Menno ter Huurne, Hendrik G. Stunnenberg
Summary: During early embryonic development, the rapid increase in cell number and the expression of genes that control developmental decisions are tightly regulated and interconnected processes. Transcription factors and signaling pathways play a crucial role in maintaining pluripotency and cell cycle progression, while canonical cell cycle regulators impact molecular networks controlling pluripotency and lineage specification.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Pooya Naseri-Nosar, Maciej T. Nogalski, Thomas Shenk
Summary: Following human cytomegalovirus (HCMV) infection, the aryl hydrocarbon receptor (AhR) is activated and alters the levels of numerous RNAs, including those related to cell cycle progression. AhR knockdown alleviates the G1/S cell cycle block in HCMV-infected fibroblasts, providing mechanistic insight into the virus-host cell interaction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Diego Lastra, Maribel Escoll, Antonio Cuadrado
Summary: This study explores the involvement of transcription factor NRF2 in the cell division cycle and finds that NRF2 levels are highest during S phase entry and lowest during mitosis. NRF2 depletion leads to G1 and M arrest and affects key cell cycle regulators.
Article
Oncology
Yaoyao Gu, Xiaoxiao Hu, Xiaowei Liu, Cheng Cheng, Kai Chen, Yeming Wu, Zhixiang Wu
Summary: High expression of MCM6 is associated with advanced tumor stage, high risk, and poor prognosis in neuroblastoma. Inhibition of MCM6 significantly impairs neuroblastoma cell proliferation, migration, and invasion. MCM6 is considered a driver of G1/S cell cycle progression and a potential therapeutic target in neuroblastoma.
Article
Engineering, Biomedical
Ryosuke Koide, Nozomi Hirane, Daiki Kambe, Yasuhiro Yokoi, Michiru Otaki, Shin-Ichiro Nishimura
Summary: This study presents a novel method for predicting and targeting pre-metastatic sites using fluorescent cancer glyconanosomes. The in vivo imaging revealed that the distribution of cancer glyconanosomes in mice depends strongly on cancer cell-type-specific N-glycosylation patterns. Furthermore, the study demonstrated that artificial reproduction of organ biodistribution can be achieved by mimicking cancer cell-specific glycosylation patterns.
Review
Immunology
Ye Jin, Jianming Xing, Kejin Xu, Da Liu, Yue Zhuo
Summary: Exosomes, produced by endosomes, play a crucial role in intercellular communication. Over the past few decades, there has been growing recognition of the importance of exosomes in the tumor microenvironment and their connection to cancer development. This paper discusses the composition, generation, uptake, and roles of exosomes in tumor metastasis, angiogenesis, and immunosuppression. Understanding the biological characteristics of exosomes and their functions in tumor development is significant for identifying new diagnostic biomarkers and therapeutic targets for cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Shuya Huang, Xiang Shu, Jie Ping, Jie Wu, Jifeng Wang, Chris Shidal, Xingyi Guo, Joshua A. Bauer, Jirong Long, Xiao-Ou Shu, Wei Zheng, Qiuyin Cai
Summary: A genetic variant, rs34331122, in the 22q11.21 locus was found to be associated with breast cancer risk and also regulated TBX1 gene expression. Higher expression of TBX1 was observed in breast cancer tumors and was associated with worse outcomes in patients. Knock-down of TBX1 inhibited breast cancer cell proliferation, migration, and invasion, and induced cell cycle arrest in the G1 phase.
Article
Dermatology
Shih-Fan Lai, Wen-Yen Huang, Wei-Hung Wang, Jin-Bon Hong, Sung-Hsin Kuo, Sung-Jan Lin
Summary: This study found that local administration of prostaglandin E2 (PGE2) can effectively reduce radiotherapy-induced alopecia (RIA) and promote hair follicle (HF) self-repair. It was discovered that PGE2 can transiently arrest transit amplifying cells (TACs) in the G1 phase, thereby reducing apoptosis and dystrophy of HFs, and accelerating their regeneration. This study provides a new treatment option for the prevention of RIA.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jia-Long Qi, Jin-Rong He, Cun-Bao Liu, Shu-Mei Jin, Xu Yang, Hong-Mei Bai, Yan-Bing Ma
Summary: This study reveals that overexpression of SQSTM1/p62 in breast cancer is correlated with poor prognosis. Silencing SQSTM1/p62 expression inhibits breast cancer progression by regulating cell proliferation and reshaping the tumor microenvironment. This finding provides a novel molecular therapeutic strategy for breast cancer treatment.
Article
Biochemistry & Molecular Biology
Zuzana Nascakova, Barbora Boleslavska, Vaclav Urban, Anna Oravetzova, Edita Vlachova, Pavel Janscak, Jana Dobrovolna
Summary: R-loops are three-stranded structures formed by annealing of nascent transcripts and template DNA, playing important roles in physiological processes. Dysregulation of R-loop metabolism may pose a threat to genome stability. Depletion of RAD51 and inhibition by B02 did not prevent R-loop formation in human cells, while B02 treatment may lead to premature origin firing caused by RAD51-dependent accumulation of R-loops.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Feng Tian, Daxia Cai
Summary: The study revealed that GNAZ is overexpressed in HCC tissues and is associated with poor prognosis, promoting tumor proliferation through cell cycle, apoptosis, migration, and invasion pathways.
Article
Microbiology
Ying Jiang, Caice Liang, Wei Zhao, Tianpeng Chen, Bin Yu, Anqi Hou, Jiaqing Zhu, Tao Zhang, Qingguo Liu, Hanjie Ying, Dong Liu, Wenjun Sun, Yong Chen
Summary: Immobilised fermentation using biofilm resistance can improve fermentation efficiency and yield, and the cell cycle influences biofilm formation by regulating cell adhesion and polysaccharide formation.
MICROBIOLOGY SPECTRUM
(2022)
Review
Biochemistry & Molecular Biology
Nischal Koirala, Nandini Dey, Jennifer Aske, Pradip De
Summary: HER2 is a cancer-causing driver gene in a subset of breast cancer. Despite the availability of several anti-HER2 targeted therapies, most patients with metastatic HER2+ breast cancer still die from the disease. Cell cycle inhibitors, specifically CDK 4/6 inhibitors, have shown success in managing hormone receptor-positive breast cancer and have the potential for application in HER2+ breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Hao Luo, Lu Zhai, Weifeng Qiu, Hairong Liang, Lei Yu, Yuan Li, Mengyun Xiong, Jiaying Guo, Huanwen Tang
Summary: The study revealed that the p16/Rb signal pathway is suppressed in hydroquinone-induced malignant transformation of TK6 cells, resulting in enhanced cell proliferation and accelerated cell cycle progression. It was further confirmed that p16 regulates cell cycle progression via Rb and p53, indicating its involvement in hydroquinone-induced malignant transformation.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Qingqing Hu, Qiuhong Liu, Yalei Zhao, Lingjian Zhang, Lanjuan Li
Summary: This study reveals that SGOL2 acts as an oncogene in hepatocellular carcinoma (HCC) by regulating MAD2 and dysregulating the cell cycle, providing a potential therapeutic target for HCC.
BIOMARKER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Kevin M. Tharp, Valerie M. Weaver
JOURNAL OF MOLECULAR BIOLOGY
(2018)
Article
Cell Biology
J. Matthew Barnes, Shelly Kaushik, Russell O. Bainer, Jason K. Sa, Elliot C. Woods, FuiBoon Kai, Laralynne Przybyla, Mijeong Lee, Hye Won Lee, Jason C. Tung, Ori Maller, Alexander S. Barrett, Kan V. Lu, Jonathon N. Lakins, Kirk C. Hansen, Kirsten Obernier, Arturo Alvarez-Buylla, Gabriele Bergers, Joanna J. Phillips, Do-Hyun Nam, Carolyn R. Bertozzi, Valerie M. Weaver
NATURE CELL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Stacy A. Malaker, Kayvon Pedram, Michael J. Ferracane, Barbara A. Bensing, Venkatesh Krishnan, Christian Pett, Jin Yu, Elliot C. Woods, Jessica R. Kramer, Ulrika Westerlind, Oliver Dorigo, Carolyn R. Bertozzi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Carolyn R. Shurer, Joe Chin-Hun Kuo, LaDeidra Monet Roberts, Jay G. Gandhi, Marshall J. Colville, Thais A. Enoki, Hao Pan, Jin Su, Jade M. Noble, Michael J. Hollander, John P. O'Donnell, Rose Yin, Kayvon Pedram, Leonhard Mockl, Lena F. Kourkoutis, W. E. Moerner, Carolyn R. Bertozzi, Gerald W. Feigenson, Heidi L. Reesink, Matthew J. Paszek
Review
Biology
Nadia M. E. Ayad, Shelly Kaushik, Valerie M. Weaver
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Amanda N. Steele, Michael J. Paulsen, Hanjay Wang, Lyndsay M. Stapleton, Haley J. Lucian, Anahita Eskandari, Camille E. Hironaka, Justin M. Farry, Samuel W. Baker, Akshara D. Thakore, Kevin J. Jaatinen, Yuko Tada, Michael J. Hollander, Kiah M. Williams, Alexis J. Seymour, Kailey P. Totherow, Anthony C. Yu, Jennifer R. Cochran, Eric A. Appel, Y. Joseph Woo
Review
Cell Biology
Alexander Buffone, Valerie M. Weaver
JOURNAL OF CELL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Vincent C. Luca, Yi Miao, Xingnan Li, Michael J. Hollander, Calvin J. Kuo, K. Christopher Garcia
Article
Multidisciplinary Sciences
Olga M. Anton, Mary E. Peterson, Michael J. Hollander, David W. Dorward, Gunjan Arora, Javier Traba, Sumati Rajagopalan, Erik L. Snapp, K. Christopher Garcia, Thomas A. Waldmann, Eric O. Long
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Melissa A. Gray, Michal A. Stanczak, Natalia R. Mantuano, Han Xiao, Johan F. A. Pijnenborg, Stacy A. Malaker, Caitlyn L. Miller, Payton A. Weidenbacher, Julia T. Tanzo, Green Ahn, Elliot C. Woods, Heinz Laeubli, Carolyn R. Bertozzi
NATURE CHEMICAL BIOLOGY
(2020)
Article
Cell Biology
Abigail A. Kindberg, Vasudha Srivastava, Jonathon M. Muncie, Valerie M. Weaver, Zev J. Gartner, Jeffrey O. Bush
Summary: The study reveals that EPH/EPHRIN signaling decreases the stability of heterotypic cell:cell contacts through increased cortical actomyosin contractility, driving cellular self-organization. The cell segregation driven by EPH/EPHRIN depends on actomyosin contractility but occurs independently of directed cell migration and without changes in cell adhesion.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Qian Zhang, Morgan E. Hresko, Lora K. Picton, Leon Su, Michael J. Hollander, Selene Nunez-Cruz, Zheng Zhang, Charles-Antoine Assenmacher, Jonathan T. Sockolosky, K. Christopher Garcia, Michael C. Milone
Summary: Researchers have successfully created a pair of human orthogonal IL-2 and orthogonal IL-2 receptor through engineering, which can deliver IL-2 signal without toxicity, and demonstrated that this approach can enhance the antitumor efficacy of engineered T cells.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Jason J. Northey, Valerie M. Weaver
Summary: Mechanical forces and steroid hormones play important roles in regulating cell fate and tissue development. Aberrant steroid hormone action is associated with tumor origin, while prolonged perturbations to mechanical forces may lead to tumor progression and the development of aggressive metastatic diseases.
Review
Cell Biology
Josette M. Northcott, Ivory S. Dean, Janna K. Mouw, Valerie M. Weaver
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
N. Ramakrishnan, K. K. Sreeja, Arpita Roychoudhury, David M. Eckmann, Portonovo S. Ayyaswamy, Tobias Baumgart, Thomas Pucadyil, Shivprasad Patil, Valerie M. Weaver, Ravi Radhakrishnan