Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior

(2017) Nicholas J Edwards et al.   NATURE NEUROSCIENCE

Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons

(2017) Corey Baimel et al.   Cell Reports

Buprenorphine + naloxone plus naltrexone for the treatment of cocaine dependence: the Cocaine Use Reduction with Buprenorphine (CURB) study

(2016) Walter Ling et al.   ADDICTION

Sustained-Release Buprenorphine (RBP-6000) Blocks the Effects of Opioid Challenge With Hydromorphone in Subjects With Opioid Use Disorder

(2016) Azmi F. Nasser et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice

(2016) Nora M McCall et al.   NEUROPSYCHOPHARMACOLOGY

The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism

(2015) James D. Robinson et al.   CELLULAR SIGNALLING

Maturational alterations in constitutive activity of medial prefrontal cortex kappa-opioid receptors in Wistar rats

(2015) Sunil Sirohi et al.   JOURNAL OF NEUROCHEMISTRY

Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons

(2015) J. M. Ehrich et al.   JOURNAL OF NEUROSCIENCE

Dynorphin, Dysphoria and Dependence: the Stress of Addiction

(2015) Charles Chavkin et al.   NEUROPSYCHOPHARMACOLOGY

Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

(2015) John R Mantsch et al.   NEUROPSYCHOPHARMACOLOGY

Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment

(2015) Nicole A. Crowley et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Poststress Block of Kappa Opioid Receptors Rescues Long-Term Potentiation of Inhibitory Synapses and Prevents Reinstatement of Cocaine Seeking

(2014) Abigail M. Polter et al.   BIOLOGICAL PSYCHIATRY

Orexin/hypocretin role in reward: implications for opioid and other addictions

(2014) Corey Baimel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stress and VTA synapses: implications for addiction and depression

(2014) Abigail M. Polter et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Safety, Tolerability, and Clinical Effect of Low-Dose Buprenorphine for Treatment-Resistant Depression in Midlife and Older Adults

(2014) Jordan F. Karp et al.   JOURNAL OF CLINICAL PSYCHIATRY

Evaluation of Opioid Modulation in Major Depressive Disorder

(2014) Elliot Ehrich et al.   NEUROPSYCHOPHARMACOLOGY

Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area

(2014) J. W. Muschamp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The vital role of constitutive GPCR activity in the mesolimbic dopamine system

(2014) F J Meye et al.   Translational Psychiatry

Sex Differences in Sensitivity to the Depressive-like Effects of the Kappa Opioid Receptor Agonist U-50488 in Rats

(2013) Shayla E. Russell et al.   BIOLOGICAL PSYCHIATRY

Persistent Receptor Activity Underlies Group I mGluR-Mediated Cellular Plasticity in CA3 Neuron

(2013) S. R. Young et al.   JOURNAL OF NEUROSCIENCE

Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity

(2013) Nicholas M. Graziane et al.   NEURON

LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders

(2013) Linda M. Rorick-Kehn et al.   NEUROPHARMACOLOGY

Role of kappa-opioid receptors in stress and anxiety-related behavior

(2013) Ashlee Van’t Veer et al.   PSYCHOPHARMACOLOGY

Constitutive  -Opioid Receptor Activity Leads to Long-Term Endogenous Analgesia and Dependence

(2013) G. Corder et al.   SCIENCE

Involvement of dynorphin and kappa opioid receptor in yohimbine-induced reinstatement of heroin seeking in rats

(2013) Yan Zhou et al.   SYNAPSE

Morphine Withdrawal Enhances Constitutive  -Opioid Receptor Activity in the Ventral Tegmental Area

(2012) F. J. Meye et al.   JOURNAL OF NEUROSCIENCE

Input-specific control of reward and aversion in the ventral tegmental area

(2012) Stephan Lammel et al.   NATURE

Activation of VTA GABA Neurons Disrupts Reward Consumption

(2012) Ruud van Zessen et al.   NEURON

GABA Neurons of the VTA Drive Conditioned Place Aversion

(2012) Kelly R. Tan et al.   NEURON

Effects of a Post-Shock Injection of the Kappa Opioid Receptor Antagonist Norbinaltorphimine (norBNI) on Fear and Anxiety in Rats

(2012) Benjamin Rogala et al.   PLoS One

Are you or aren’t you? Challenges associated with physiologically identifying dopamine neurons

(2012) Mark A. Ungless et al.   TRENDS IN NEUROSCIENCES

Repeated Exposure to the κ-Opioid Receptor Agonist Salvinorin A Modulates Extracellular Signal-Regulated Kinase and Reward Sensitivity

(2011) David N. Potter et al.   BIOLOGICAL PSYCHIATRY

Projection-Specific Modulation of Dopamine Neuron Synapses by Aversive and Rewarding Stimuli

(2011) Stephan Lammel et al.   NEURON

Persistent Increases in Cocaine-Seeking Behavior After Acute Exposure to Cold Swim Stress

(2010) Kelly L. Conrad et al.   BIOLOGICAL PSYCHIATRY

Drugs of abuse and stress impair LTP at inhibitory synapses in the ventral tegmental area

(2010) Jason L. Niehaus et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Extracellular Signal-Regulated Kinase-2 within the Ventral Tegmental Area Regulates Responses to Stress

(2010) S. D. Iniguez et al.   JOURNAL OF NEUROSCIENCE

Ventral Tegmental Afferents in Stress-Induced Reinstatement: The Role of cAMP Response Element-Binding Protein

(2010) L. A. Briand et al.   JOURNAL OF NEUROSCIENCE

Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling

(2010) E. J. Melief et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse

(2010) Sunmee Wee et al.   PSYCHOPHARMACOLOGY

Kinase cascades and ligand-directed signaling at the kappa opioid receptor

(2010) Michael R. Bruchas et al.   PSYCHOPHARMACOLOGY

The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors

(2009) M.R. Bruchas et al.   BRAIN RESEARCH

PKG and PKA Signaling in LTP at GABAergic Synapses

(2009) Fereshteh S Nugent et al.   NEUROPSYCHOPHARMACOLOGY

Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking

(2009) Benjamin B. Land et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cocaine but Not Natural Reward Self-Administration nor Passive Cocaine Infusion Produces Persistent LTP in the VTA

(2008) Billy T. Chen et al.   NEURON

Unique Properties of Mesoprefrontal Neurons within a Dual Mesocorticolimbic Dopamine System

(2008) Stephan Lammel et al.   NEURON

Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system

(2008) Van A. Redila et al.   PSYCHOPHARMACOLOGY