Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis

(2017) Sarah A Boswell et al.   Nature Chemical Biology

SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing

(2017) Berta Pozzi et al.   NUCLEIC ACIDS RESEARCH

Bcl-2 Family Proteins Regulate Apoptosis and Epithelial to Mesenchymal Transition by Calcium Signals

(2016) Yanjiao Wu et al.   CURRENT PHARMACEUTICAL DESIGN

Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy

(2016) Hasane Ratni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy

(2016) Matthew G. Woll et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comment on “SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML”

(2016) Omar Ferhi et al.   Science Signaling

The Spliceosome: The Ultimate RNA Chaperone and Sculptor

(2016) Panagiotis Papasaikas et al.   TRENDS IN BIOCHEMICAL SCIENCES

Comment on “SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML”

(2016) Omar Ferhi et al.   Science Signaling

Alternative splicing as a biomarker and potential target for drug discovery

(2015) Kai-qin Le et al.   ACTA PHARMACOLOGICA SINICA

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

(2015) Yeon Lee et al.   Annual Review of Biochemistry

A Splicing Reporter Tuned to Non-AG Acceptor Sites Reveals that Luteolin Enhances the Recognition of Non-canonical Acceptor Sites

(2015) Masanori Chiba et al.   Chemical Biology & Drug Design

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

(2015) Pedro Fong et al.   JOURNAL OF ETHNOPHARMACOLOGY

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1

(2015) M Larrayoz et al.   LEUKEMIA

Functional Splicing Network Reveals Extensive Regulatory Potential of the Core Spliceosomal Machinery

(2015) Panagiotis Papasaikas et al.   MOLECULAR CELL

Proteome-wide identification of SUMO modification sites by mass spectrometry

(2015) Triin Tammsalu et al.   Nature Protocols

Finding the rules of splicing, and using them … alternatively

(2015) Benoit Chabot   RNA

System-wide identification of wild-type SUMO-2 conjugation sites

(2015) Ivo A. Hendriks et al.   Nature Communications

The spliceosome: disorder and dynamics defined

(2014) Weijun Chen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Discovery of potent inhibitor for matrix metalloproteinase-9 by pharmacophore based modeling and dynamics simulation studies

(2014) Sukesh Kalva et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Important Role of SUMOylation of Spliceosome Factors in Prostate Cancer Cells

(2014) Donghua Wen et al.   JOURNAL OF PROTEOME RESEARCH

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Inhibition of U4 snRNA in Human Cells Causes the Stable Retention of Polyadenylated Pre-mRNA in the Nucleus

(2014) Anne Hett et al.   PLoS One

SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy

(2014) N. A. Naryshkin et al.   SCIENCE

Proteome-Wide Identification of SUMO2 Modification Sites

(2014) T. Tammsalu et al.   Science Signaling

Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells

(2014) Yang Gao et al.   Scientific Reports

Chemical Perturbation of Mcl-1 Pre-mRNA Splicing to Induce Apoptosis in Cancer Cells

(2013) Yang Gao et al.   ACS Chemical Biology

Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets

(2013) D. Arango et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemistry and Biological Activities of Flavonoids: An Overview

(2013) Shashank Kumar et al.   TheScientificWorldJOURNAL

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer

(2012) Thomas R. Webb et al.   DRUG DISCOVERY TODAY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs

(2011) Evgeny M. Makarov et al.   NUCLEIC ACIDS RESEARCH

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

(2010) C. J. David et al.   GENES & DEVELOPMENT

The serine/arginine-rich protein SF2/ASF regulates protein sumoylation

(2010) F. Pelisch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Combination of FASP and StageTip-Based Fractionation Allows In-Depth Analysis of the Hippocampal Membrane Proteome

(2009) Jacek R. Wiśniewski et al.   JOURNAL OF PROTEOME RESEARCH

The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing

(2008) Kristine O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS