Article
Multidisciplinary Sciences
Aida Rodriguez-Nuevo, Ariadna Torres-Sanchez, Juan M. Duran, Cristian De Guirior, Maria Angeles Martinez-Zamora, Elvan Boke
Summary: Oocytes evade the negative effects of reactive oxygen species (ROS) by eliminating complex I in the mitochondrial electron transport chain. Early oocytes have low levels of complex I and an active mitochondrial unfolded protein response. This suppression of complex I represents a strategy for maintaining biological activity while achieving longevity.
Article
Biochemistry & Molecular Biology
Miquel Angel Schikora-Tamarit, Marina Marcet-Houben, Jozef Nosek, Toni Gabaldon
Summary: By using a comparative genomics approach, eight independent events of mitochondrial complex I loss across eukaryotes were identified, six of which occurred in fungal lineages. It is hypothesized that the loss of complex I in fungi may be induced by previously acquired compensatory mechanisms and exposure to environmental triggers of oxidative stress.
Article
Cell Biology
Tao Wang, Honghe Liu, Kie Itoh, Sungtaek Oh, Liang Zhao, Daisuke Murata, Hiromi Sesaki, Thomas Hartung, Chan Hyun Na, Jiou Wang
Summary: Haploinsufficiency of C9orf72 is linked to ALS and FTD, with C9orf72 playing a role in regulating cellular energy balance by stabilizing TIMMDC1, a crucial component of OXPHOS complex I in mitochondria.
Article
Biochemistry & Molecular Biology
Adriana Morales-Martinez, Paola A. Martinez-Gomez, Daniel Martinez-Fong, Marcos M. Villegas-Rojas, Francisca Perez-Severiano, Miguel A. Del Toro-Colin, Karen M. Delgado-Minjares, Victor Manuel Blanco-Alvarez, Bertha Alicia Leon-Chavez, Omar Emiliano Aparicio-Trejo, Mauricio T. Baez-Cortes, Maria-del-Carmen Cardenas-Aguayo, Jose Luna-Munoz, Mar Pacheco-Herrero, Quetzalli D. Angeles-Lopez, Irma A. Martinez-Davila, Citlaltepetl Salinas-Lara, Jose Pablo Romero-Lopez, Carlos Sanchez-Garibay, Adolfo R. Mendez-Cruz, Luis O. Soto-Rojas
Summary: This study developed a rat model of alpha-synucleinopathy and investigated the relationship between oxidative stress, mitochondrial dysfunction, and neurodegeneration in different brain regions. The findings suggest the involvement of peroxisome proliferator-activated receptors in the pathogenesis and potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Camila D. S. Barros, Jomenica B. Livramento, Margaret G. Mouro, Elisa Mieko Suemitsu Higa, Carlos T. Moraes, Celia Harumi Tengan
Summary: Supplementation of L-arginine may improve symptoms in MELAS patients by reducing protein nitration.
Article
Oncology
Raj K. Gopal, Venkata R. Vantaku, Apekshya Panda, Bryn Reimer, Sneha Rath, Tsz-Leung To, Adam S. Fisch, Murat Cetinbas, Maia Livneh, Michael J. Calcaterra, Benjamin J. Gigliotti, Kerry A. Pierce, Clary B. Clish, Dora Dias-Santagata, Peter M. Sadow, Lori J. Wirth, Gilbert H. Daniels, Ruslan I. Sadreyev, Vamsi K. Mootha
Summary: Oncocytic (Hurthle cell) carcinoma of the thyroid (HCC) is characterized by mitochondrial DNA mutations and chromosomal losses. Glutathione biosynthesis, amino acid metabolism, and lipid peroxide scavenging are increased in HCC cells. Loss of GPX4, a defense against lipid peroxides, is a liability in HCC. Rescuing complex I redox activity reduces ferroptosis sensitivity in HCC cells, while inhibiting complex I in normal thyroid cells enhances ferroptosis induction. Lipid peroxide stress is a vulnerability in HCC coupled to genetic loss of mitochondrial complex I activity.
Article
Oncology
Tanaya Lahiri, Lara Brambilla, Joshua Andrade, Manor Askenazi, Beatrix Ueberheide, David E. Levy
Summary: Mitochondrial STAT3 regulates complex I dehydrogenase activity, impacting NAD+ regeneration, thus indirectly controlling antioxidant gene expression to promote proliferation and migration in triple-negative breast cancer cells.
MOLECULAR ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Man-Huan Xiao, Yi-Fang Lin, Peng-Peng Xie, Hua-Xing Chen, Jun-Wen Deng, Wei Zhang, Na Zhao, Chen Xie, Yu Meng, Xingguo Liu, Shi-Mei Zhuang, Ying Zhu, Jian-Hong Fang
Summary: This study reveals that downregulation of MPM is associated with increased metastasis potential and recurrence in hepatocellular carcinoma. The restoration of MPM expression inhibits migration and invasion of hepatoma cells, while silencing MPM increases their metastasis ability. MPM interacts with NDUFA7 and regulates mitochondrial complex I activity and the NAD(+)/NADH ratio. miR-17-5p binds to MPM and suppresses its expression.
Article
Biology
Ahmed-Noor A. Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J. Whitworth, Judy Hirst
Summary: Respiratory complex I in Drosophila melanogaster has a 43-subunit structure with high homology to the mammalian counterpart. It is in a mammalian-type active resting state, with a fully ordered and enclosed ubiquinone-binding site, but with subtle conformational changes. The deactive resting state observed in mammals is not seen, but minor states with a deactive-type pi-bulge in subunit ND6-TMH3 are present.
Article
Multidisciplinary Sciences
Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri
Summary: Mitochondrial complex I deficiency is common in congenital, neurologic, and cardiovascular diseases. This study reveals that Complex I stimulates the turnover of a mitochondrial calcium channel, preserving energetic homeostasis during Complex I deficiency. Calcium influx into mitochondria enhances ATP synthesis and is increased in cardiomyopathies caused by mitochondrial dysfunction. The impairment of Complex I leads to increased activity of the mitochondrial calcium uniporter channel. The authors propose that calcium influx compensates for Complex I dysfunction via an impairment in Complex I-induced protein turnover and Uniporter stabilization.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Heloisa Aparecida Barbosa Silva Pereira, Tamara Teodoro Araujo, Aline Dionizio, Juliana Sanches Trevizol, Fabricio Soares Pereira, Flavia Godoy Iano, Valdecir Faria Ximenes, Marilia Afonso Rabelo Buzalaf
Summary: The study found that fluoride can induce changes in the expression of liver mitochondrial proteins, with its effects dependent on dosage and exposure time. Different fluoride concentrations and exposure periods resulted in varying effects on the mitochondrial complex activities in the liver. Long-term exposure to high fluoride doses may trigger an adaptive mechanism in the body to counteract the harmful effects of fluoride on energy metabolism, by activating complex I-III in mitochondria.
Article
Cell Biology
Meng Gao, Yuan Qin, Anqi Li, Sailei Wei, Bilin Liu, Xiangang Tian, Guohua Gong
Summary: Previous research has shown that mitoflash genesis is functionally and mechanistically integrated with mitochondrial electron transport chain energy metabolism. Blocking the complete electron flow from Complex I to IV with ETC inhibitors abolishes mitoflashes triggered by substrates in adult permeabilized cardiomyocytes. The Qo site of Complex III is critical to mitoflash generation and activity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yinghua Fu, Zhenglei Li, Shiqi Xiao, Caiyun Zhao, Keqiang Zhou, Shenyi Cao
Summary: The study demonstrates that flavonoids in chickpeas can alleviate NAD(+)/NADH redox imbalance and mitochondrial complex I dysfunction in the pancreas, as well as reduce oxidative stress and improve dyslipidemia in type 2 diabetes mellitus (T2DM) rats.
Review
Pharmacology & Pharmacy
Eugenia Trushina, Sergey Trushin, Md Fayad Hasan
Summary: Alzheimer's disease, the most common form of dementia in the elderly, has no cure. Emerging data suggest that mitochondria can initiate an integrated stress response that is beneficial for healthy aging and neuroprotection. Partial inhibition of mitochondrial complex I has been explored as a treatment strategy for various diseases, including Alzheimer's disease.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Materials Science, Biomaterials
Zhaoguo Hong, Jingjing Zhong, Sihui Gong, Sudi Huang, Qiongqiong Zhong, Dangdang Ding, Hedong Bian, Hong Liang, Fu-Ping Huang
Summary: A new metal complex CDT agent was developed to efficiently induce oxidative damage and generate large amounts of hydroxyl radicals, leading to cell death, with excellent tumor growth inhibition capability shown in in vivo experiments.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Psychiatry
Sarah Sohyun Park, Hyunjin Jeong, Ana C. Andreazza
Summary: The study found varying levels of ccf-mtDNA in peripheral and CSF samples related to neuropsychiatric and non-psychiatric neurological diseases, suggesting mitochondrial stress is mainly associated with the latter.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Immunology
Sudhir Karthikeyan, Mikaela K. Dimick, Lisa Fiksenbaum, Hyunjin Jeong, Boris Birmaher, James L. Kennedy, Krista Lanctot, Anthony J. Levitt, Gregory E. Miller, Ayal Schaffer, L. Trevor Young, Eric A. Youngstrom, Ana C. Andreazza, Benjamin I. Goldstein
Summary: Elevated levels of pro-inflammatory marker CRP and lower levels of anti-inflammatory marker IL-10 were found in adolescents with BD during the most severe symptomatic interval, indicating a potential association with the course of BD symptoms. Future larger studies are needed to further investigate these findings.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Giulia Cisbani, Alex Koppel, Adam H. Metherel, Mackenzie E. Smith, Kankana N. Aji, Ana C. Andreazza, Romina Mizrahi, Richard P. Bazinet
Summary: Cannabis use is associated with increased fatty acid metabolism, as indicated by higher levels of saturated and monounsaturated fatty acids in the serum of cannabis users compared to nonusers. The elevated lipogenic activity in cannabis users may be influenced by the endocannabinoid 2-arachidonoylglycerol, which could activate the cannabinoid receptor 1. However, further studies are needed to confirm these findings and control for dietary intake.
Article
Clinical Neurology
Jinghan Jenny Chen, Mathura Thiyagarajah, Jianmeng Song, Clara Chen, Nathan Herrmann, Damien Gallagher, Mark J. Rapoport, Sandra E. Black, Joel Ramirez, Ana C. Andreazza, Paul Oh, Susan Marzolini, Simon J. Graham, Krista L. Lanctot
Summary: This meta-analysis examined the levels of GSH in the brain and blood of patients with AD and MCI compared to healthy controls. The results showed that brain GSH did not differ significantly in AD and MCI compared to healthy controls. However, lower brain GSH was observed in AD and MCI patients in studies using MEGA-PRESS. In addition, AD patients had lower levels of intracellular and extracellular blood GSH, and MCI patients had lower levels of intracellular blood GSH.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Review
Clinical Neurology
Melvin G. McInnis, Ole A. Andreassen, Ana C. Andreazza, Uri Alon, Michael Berk, Teri Brister, Katherine E. Burdick, Donghong Cui, Mark Frye, Marion Leboyer, Philip B. Mitchell, Kathleen Merikangas, Andrew A. Nierenberg, John Nurnberger, Daniel Pham, Eduard Vieta, Lakshmi N. Yatham, Allan H. Young
Summary: Bipolar disorder is a complex condition with onset in late adolescence, complicated by comorbid medical and psychiatric disorders. The etiology and reliable biological markers remain unknown, suggesting the need for large-scale global longitudinal studies to determine causes and improve treatment.
Article
Multidisciplinary Sciences
Emmalin Buajitti, Laura C. Rosella, Ersi Zabzuni, L. Trevor Young, Ana C. Andreazza
Summary: This study used administrative data from Ontario, Canada to measure the prevalence, patient characteristics, and healthcare costs of mitochondrial disease, showing a prevalence rate of 1 in 3989. The findings highlight the high healthcare burden and costs incurred by patients with mitochondrial disease in the Ontario healthcare system.
Article
Neurosciences
Vivian Feng, Shankar Tumati, Ruoding Wang, Kritleen K. Bawa, Damien Gallagher, Nathan Herrmann, Susan Marzolini, Paul Oh, Ana Andreazza, Krista L. Lanctot
Summary: This study found that markers of late-stage lipid peroxidation are elevated in coronary artery disease patients with poor sleep and are associated with daily disturbances. However, this association is not related to other factors or with sleep quality and its factors after exercise intervention.
Article
Cardiac & Cardiovascular Systems
Etienne Abdelnour-Berchtold, Aadil Ali, Cristina Baciu, Erika L. Beroncal, Aizhou Wang, Olivia Hough, Mitsuaki Kawashima, Manyin Chen, Yu Zhang, Mingyao Liu, Tom Waddell, Ana C. Andreazza, Shaf Keshavjee, Marcelo Cypel
Summary: Injured donor lungs stored at 10℃ demonstrated superior oxygenation and protective effects compared to the current clinical standard of 4℃ storage.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Medicine, Research & Experimental
Timofei Chernega, Jaehyoung Choi, Leonardo Salmena, Ana Cristina Andreazza
Summary: This article investigates the current treatment options for mitochondrial diseases and explores the potential of RNA-based therapeutic strategies, including the use of ASOs and RNAi drugs, allotopic therapies, and RNA-based antigenomic therapies. Furthermore, various mechanisms for delivering RNA therapeutic agents to the mitochondrial matrix are reviewed.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Medicine, General & Internal
Aadil Ali, Antti I. Nykanen, Erika Beroncal, Edson Brambate, Andrea Mariscal, Vinicius Michaelsen, Aizhou Wang, Mitsuaki Kawashima, Rafaela V. P. Ribeiro, Yu Zhang, Eddy Fan, Laurent Brochard, Jonathan Yeung, Tom Waddell, Mingyao Liu, Ana C. Andreazza, Shaf Keshavjee, Marcelo Cypel
Summary: This study demonstrates for the first time the feasibility of three-day lung preservation, leading to excellent early post-transplant outcomes. The combination of cold storage and intermittent ex vivo lung perfusion opens up new opportunities in organ transplantation.
Article
Clinical Neurology
David J. Bond, Ana C. Andreazza, Ivan J. Torres, William G. Honer, Raymond W. Lam, Lakshmi N. Yatham
Summary: This study found that inflammation, measured by a composite measure of total peripheral inflammation, is associated with lower white matter volumes in the frontal and temporal lobes of patients with early-stage BD. Total inflammation is a stronger predictor of lower white matter volumes than individual cytokines.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Yi Zou, Anahit Grigorian, Kody G. G. Kennedy, Clement C. C. Zai, Suyi Shao, James L. L. Kennedy, Ana C. C. Andreazza, Stephanie H. H. Ameis, Chinthaka Heyn, Bradley J. J. Maclntosh, Benjamin I. I. Goldstein
Summary: Oxidative stress is associated with white matter diffusion metrics in adults with bipolar disorder (BD). This study examined the association of single-nucleotide polymorphisms in the oxidative stress system with fractional anisotropy (FA) and radial diffusivity (RD) in youth with BD. The results showed significant diagnosis-by-genotype interaction effects for FA and RD, suggesting that the SOD2 rs4880 GG genotype may attenuate the salutary antioxidant effects on white matter integrity in youth with BD. Future studies are needed to explore other genetic markers and oxidative stress biomarkers.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Cell & Tissue Engineering
David F. Bodenstein, Pavel Powlowski, Kassandra A. Zachos, Dana El Soufi El Sabbagh, Hyunjin Jeong, Liliana Attisano, Landon Edgar, Douglas C. Wallace, Ana Cristina Andreazza
Summary: Mitochondrial dysfunction is related to various diseases, and autologous mitochondrial transplantation is a potential approach for treating mitochondrial dysfunction. The use of a 5-μm filter B provides high-quality and pure mitochondria for isolation.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Neurosciences
Angela Duong, Hyunjin Jeong, Dana El Soufi El Sabbagh, Ana C. Andreazza
Summary: On March 11, 2020, the World Health Organization declared the outbreak of SARS-CoV-2 as a global pandemic. In patients with SARS-CoV-2, inflammatory markers such as interleukin 6 and C-reactive protein are consistently elevated. This study investigates whether psychiatric patients with preexisting elevated interleukin 6 and C-reactive protein are more susceptible to severe COVID-19 complications.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
Article
Neurosciences
Diulie Valente de Souza, Lauren Pappis, Thuany Teixeira Bandeira, Gabriela Geraldo Sangoi, Tuyla Fontana, Vitor Braga Rissi, Michele Rorato Sagrillo, Marta Maria Duarte, Thiago Duarte, David Frederick Bodenstein, Ana Cristina Andreazza, Ivana Beatrice Manica da Cruz, Euler Esteves Ribeiro, Alfredo Antoniazzi, Aline Ferreira Ourique, Alencar Kolinski Machado
Summary: Neuropsychiatric diseases are a significant global burden, and an extract from acai berries shows potential as an anti-neuroinflammatory agent, reducing cellular proliferation and oxidative stress.
NUTRITIONAL NEUROSCIENCE
(2022)