Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
出版年份 2017 全文链接
标题
Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
作者
关键词
Influenza viruses, Viral replication, Wireless sensor networks, Small interfering RNAs, Phosphorylation, Protein expression, Immunoblot analysis, Protein translation
出版物
PLoS Pathogens
Volume 13, Issue 9, Pages e1006635
出版商
Public Library of Science (PLoS)
发表日期
2017-09-28
DOI
10.1371/journal.ppat.1006635
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Novel H7N9 Influenza A Virus NS1 Induces p53-Mediated Apoptosis of A549 Cells
- (2016) Yinxia Yan et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Downregulation of RSK2 influences the biological activities of human osteosarcoma cells through inactivating AKT/mTOR signaling pathways
- (2016) QUANHE QIU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The NS1 protein of avian influenza virus H9N2 induces oxidative-stress-mediated chicken oviduct epithelial cells apoptosis
- (2016) Xuefeng Qi et al. JOURNAL OF GENERAL VIROLOGY
- Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding
- (2015) Shashank Tripathi et al. Cell Host & Microbe
- La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)
- (2015) Bruno D. Fonseca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RIG-I in RNA virus recognition
- (2015) Alison M. Kell et al. VIROLOGY
- PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
- (2015) P. Liu et al. Cancer Discovery
- Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development
- (2014) Tokiko Watanabe et al. Cell Host & Microbe
- Cellular Inhibitor of Apoptosis Protein cIAP2 Protects against Pulmonary Tissue Necrosis during Influenza Virus Infection to Promote Host Survival
- (2014) Ian Gaël Rodrigue-Gervais et al. Cell Host & Microbe
- The Genome Landscape of the African Green Monkey Kidney-Derived Vero Cell Line
- (2014) Naoki Osada et al. DNA RESEARCH
- Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation
- (2014) J. Tcherkezian et al. GENES & DEVELOPMENT
- Regulation of Interferon-Dependent mRNA Translation of Target Genes
- (2014) Barbara Kroczynska et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence
- (2014) J. Ayllon et al. JOURNAL OF VIROLOGY
- Making new contacts: the mTOR network in metabolism and signalling crosstalk
- (2014) Mitsugu Shimobayashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression
- (2014) M Mura et al. ONCOGENE
- REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling
- (2014) M. D. Dennis et al. Science Signaling
- mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection
- (2014) Emmanuel Datan et al. VIROLOGY
- mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts
- (2013) N. Dai et al. GENES & DEVELOPMENT
- Novel pandemic influenza A (H1N1) virus infection modulates apoptotic pathways that impact its replication in A549 cells
- (2013) Xue Wang et al. MICROBES AND INFECTION
- Cellular RNA Binding Proteins NS1-BP and hnRNP K Regulate Influenza A Virus RNA Splicing
- (2013) Pei-Ling Tsai et al. PLoS Pathogens
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export
- (2012) Liang Zhang et al. JOURNAL OF CELL BIOLOGY
- Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes
- (2012) Maroof Hasan et al. NATURE IMMUNOLOGY
- INTERFEROME v2.0: an updated database of annotated interferon-regulated genes
- (2012) Irina Rusinova et al. NUCLEIC ACIDS RESEARCH
- Host Modulators of H1N1 Cytopathogenicity
- (2012) Samuel E. Ward et al. PLoS One
- PI3K-PKB/Akt Pathway
- (2012) B. A. Hemmings et al. Cold Spring Harbor Perspectives in Biology
- Regulation and function of the RSK family of protein kinases
- (2011) Yves Romeo et al. BIOCHEMICAL JOURNAL
- Activation of mTORC2 by Association with the Ribosome
- (2011) Vittoria Zinzalla et al. CELL
- mTOR complex 2 signaling and functions
- (2011) Won Jun Oh et al. CELL CYCLE
- Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate
- (2011) Xiaoqing Gan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation
- (2011) Yi-Hung Ou et al. MOLECULAR CELL
- Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor
- (2011) Miguel A Mata et al. Nature Chemical Biology
- I B kinase and TANK-binding kinase 1 activate AKT by direct phosphorylation
- (2011) X. Xie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
- (2011) Y. Yu et al. SCIENCE
- IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry
- (2011) Eric M. Feeley et al. PLoS Pathogens
- Cellular Networks Involved in the Influenza Virus Life Cycle
- (2010) Tokiko Watanabe et al. Cell Host & Microbe
- mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
- (2010) Won Jun Oh et al. EMBO JOURNAL
- Termination of autophagy and reformation of lysosomes regulated by mTOR
- (2010) Li Yu et al. NATURE
- Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication
- (2010) Alexander Karlas et al. NATURE
- Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation
- (2010) K. Ericson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection
- (2009) Sagi D. Shapira et al. CELL
- The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus
- (2009) Abraham L. Brass et al. CELL
- Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes
- (2009) Monique Gannagé et al. Cell Host & Microbe
- REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A–DDB1 ubiquitin ligase
- (2009) Samiksha Katiyar et al. EMBO REPORTS
- Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ
- (2009) Kristopher Clark et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
- (2009) Carson C. Thoreen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human host factors required for influenza virus replication
- (2009) Renate König et al. NATURE
- Molecular mechanisms of mTOR-mediated translational control
- (2009) Xiaoju Max Ma et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The use of Random Homozygous Gene Perturbation to identify novel host-oriented targets for influenza
- (2009) Baoquan Sui et al. VIROLOGY
- Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity
- (2008) H HOFFMANN et al. ANTIVIRAL RESEARCH
- SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs
- (2008) Xiaoju Max Ma et al. CELL
- Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling
- (2008) M. P. DeYoung et al. GENES & DEVELOPMENT
- The multifunctional NS1 protein of influenza A viruses
- (2008) B. G. Hale et al. JOURNAL OF GENERAL VIROLOGY
- Avian Influenza Virus A/HK/483/97(H5N1) NS1 Protein Induces Apoptosis in Human Airway Epithelial Cells
- (2008) W. Y. Lam et al. JOURNAL OF VIROLOGY
- Drosophila RNAi screen identifies host genes important for influenza virus replication
- (2008) Linhui Hao et al. NATURE
- AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B
- (2008) A G M van Gorp et al. ONCOGENE
- Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
- (2008) A. Y. Choo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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