A Dual-Specificity Inhibitor Targets Polyphosphate Kinase 1 and 2 Enzymes To Attenuate Virulence of Pseudomonas aeruginosa

Inorganic Polyphosphate in Host and Microbe Biology

(2021) Marvin Q. Bowlin et al.   TRENDS IN MICROBIOLOGY

Polyphosphate Functions In Vivo as an Iron Chelator and Fenton Reaction Inhibitor

(2020) François Beaufay et al.   mBio

Bacterial polyphosphates interfere with the innate host defense to infection

(2020) Julian Roewe et al.   Nature Communications

Polyphosphate is an extracellular signal that can facilitate bacterial survival in eukaryotic cells

(2020) Ramesh Rijal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Pyoverdine Inhibitors Mitigate Pseudomonas aeruginosa Pathogenesis

(2019) Daniel R. Kirienko et al.   Frontiers in Microbiology

Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition

(2019) Osmel Fleitas Martínez et al.   Frontiers in Cellular and Infection Microbiology

Pyoverdine-Dependent Virulence of Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients

(2019) Donghoon Kang et al.   Frontiers in Microbiology

Discovery of potent polyphosphate kinase 1 (PPK1) inhibitors using structure-based exploration of PPK1Pharmacophoric space coupled with docking analyses

(2018) Rasha M. Bashatwah et al.   JOURNAL OF MOLECULAR RECOGNITION

Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures

(2018) Alice E. Parnell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

(2018) Vengadeshprabhu Karuppagounder et al.   PLoS One

Bisphosphonic acids and related compounds as inhibitors of nucleotide- and polyphosphate-processing enzymes: A PPK1 and PPK2 case study

(2018) Małgorzata Burda-Grabowska et al.   Chemical Biology & Drug Design

Octopaminergic Signaling Mediates Neural Regulation of Innate Immunity in Caenorhabditis elegans

(2018) Durai Sellegounder et al.   mBio

Screening a protein kinase inhibitor library against Plasmodium falciparum

(2017) Irene Hallyburton et al.   MALARIA JOURNAL

Polyphosphate granule biogenesis is temporally and functionally tied to cell cycle exit during starvation inPseudomonas aeruginosa

(2017) Lisa R. Racki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ecstasy and Agony of Assay Interference Compounds

(2017) Courtney Aldrich et al.   ACS Medicinal Chemistry Letters

Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence

(2017) M. Fata Moradali et al.   Frontiers in Cellular and Infection Microbiology

High-Throughput Genetic Screen Reveals that Early Attachment and Biofilm Formation Are Necessary for Full Pyoverdine Production by Pseudomonas aeruginosa

(2017) Donghoon Kang et al.   Frontiers in Microbiology

The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation

(2017) Jan-Ulrik Dahl et al.   Nature Microbiology

Role of Iron Uptake Systems in Pseudomonas aeruginosa Virulence and Airway Infection

(2016) Fabrizia Minandri et al.   INFECTION AND IMMUNITY

Dictyostelium discoideum as a surrogate host–microbe model for antivirulence screening in Pseudomonas aeruginosa PAO1

(2016) Catalina Bravo-Toncio et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms

(2016) Kyle C. Costa et al.   SCIENCE

Establishing Virulence Associated Polyphosphate Kinase 2 as a drug target for Mycobacterium tuberculosis

(2016) Mamta Singh et al.   Scientific Reports

Biochemical and structural characterization of polyphosphate kinase 2 from the intracellular pathogen Francisella tularensis

(2015) L. E. Batten et al.   BIOSCIENCE REPORTS

Ellagic acid derivatives fromTerminalia chebulaRetz. increase the susceptibility ofPseudomonas aeruginosato stress by inhibiting polyphosphate kinase

(2015) S. Sarabhai et al.   JOURNAL OF APPLIED MICROBIOLOGY

Involvement of polyphosphate kinase in virulence and stress tolerance of uropathogenic Proteus mirabilis

(2015) Liang Peng et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Phenazine virulence factor binding to extracellular DNA is important for Pseudomonas aeruginosa biofilm formation

(2015) Theerthankar Das et al.   Scientific Reports

Simultaneous Adrenal and Cardiac G-Protein–Coupled Receptor-G βγ Inhibition Halts Heart Failure Progression

(2014) Fadia A. Kamal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death

(2013) Natalia V. Kirienko et al.   Cell Host & Microbe

Exopolyphosphatase of Pseudomonas aeruginosa is essential for the production of virulence factors, and its expression is controlled by NtrC and PhoB acting at two interspaced promoters

(2013) L. A. Gallarato et al.   MICROBIOLOGY-SGM

Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics

(2013) Alan V. Smrcka   TRENDS IN PHARMACOLOGICAL SCIENCES

Pleiotropic effects of the mioC mutation on the physiology of Pseudomonas aeruginosa PAO1

(2012) Jinki Yeom et al.   FEMS MICROBIOLOGY LETTERS

Aptamer-Mediated Inhibition ofMycobacterium tuberculosisPolyphosphate Kinase 2

(2011) Ka To Shum et al.   BIOCHEMISTRY

Competition and Resilience between Founder and Introduced Bacteria in the Caenorhabditis elegans Gut

(2011) Cynthia Portal-Celhay et al.   INFECTION AND IMMUNITY

Pseudomonas Aeruginosa: Resistance to the Max

(2011) Keith Poole   Frontiers in Microbiology

Microtiter Dish Biofilm Formation Assay

(2011) George A. O'Toole   Jove-Journal of Visualized Experiments

Polyphosphate Kinase 2: A Novel Determinant of Stress Responses and Pathogenesis in Campylobacter jejuni

(2010) Dharanesh Gangaiah et al.   PLoS One

Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria

(2008) B. Nocek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA