Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis

Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology

(2017) Monia Barnat et al.   NEURON

Enhanced Histochemical Detection of Iron in Paraffin Sections of Mouse Central Nervous System Tissue

(2016) Scott A. Sands et al.   ASN Neuro

Osteopontin protects against high phosphate-induced nephrocalcinosis and vascular calcification

(2016) Neil J. Paloian et al.   KIDNEY INTERNATIONAL

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis

(2016) Guohao Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired myelination and reduced brain ferric iron in the mouse model of mucolipidosis IV

(2015) Y. Grishchuk et al.   Disease Models & Mechanisms

Update and Mutational Analysis ofSLC20A2: A Major Cause of Primary Familial Brain Calcification

(2015) Roberta R. Lemos et al.   HUMAN MUTATION

Germline deletion of huntingtin causes male infertility and arrested spermiogenesis in mice

(2015) Jinting Yan et al.   JOURNAL OF CELL SCIENCE

Acetazolamide sensitive tissue calcification and aging of klotho-hypomorphic mice

(2015) Christina B. Leibrock et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Therapeutic advances in Huntington's Disease

(2015) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

Artificial miRNAs Targeting Mutant Huntingtin Show Preferential Silencing In Vitro and In Vivo

(2015) Alex Mas Monteys et al.   Molecular Therapy-Nucleic Acids

Personalized gene silencing therapeutics for Huntington disease

(2014) C. Kay et al.   CLINICAL GENETICS

In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides

(2014) Amber L Southwell et al.   MOLECULAR THERAPY

Targets for future clinical trials in Huntington's disease: What's in the pipeline?

(2014) Edward J. Wild et al.   MOVEMENT DISORDERS

Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins

(2014) Douglas Macdonald et al.   PLoS One

Activation of Nrf2 by dimethyl fumarate improves vascular calcification

(2014) Chae-Myeong Ha et al.   VASCULAR PHARMACOLOGY

Ubiquitin–proteasome system involvement in Huntington’s disease

(2014) Zaira Ortega et al.   Frontiers in Molecular Neuroscience

Brain Iron Homeostasis: From Molecular Mechanisms To Clinical Significance and Therapeutic Opportunities

(2013) Neena Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Loss of Function of Slc20a2 Associated with Familial Idiopathic Basal Ganglia Calcification in Humans Causes Brain Calcifications in Mice

(2013) Nina Jensen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

(2013) Annika Keller et al.   NATURE GENETICS

Huntingtin Acts Non Cell-Autonomously on Hippocampal Neurogenesis and Controls Anxiety-Related Behaviors in Adult Mouse

(2013) Patrick Pla et al.   PLoS One

Iron-Responsive miR-485-3p Regulates Cellular Iron Homeostasis by Targeting Ferroportin

(2013) Carolyn Sangokoya et al.   PLoS Genetics

Expression and Function of Ferroportin 1 in O-2A Progenitor Cells

(2012) Qing Lin et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action

(2012) Alfons Lawen et al.   ANTIOXIDANTS & REDOX SIGNALING

Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum

(2012) Richard Grondin et al.   BRAIN

The group 2 metabotropic glutamate receptor agonist LY379268 rescues neuronal, neurochemical and motor abnormalities in R6/2 Huntington's disease mice

(2012) A. Reiner et al.   NEUROBIOLOGY OF DISEASE

Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification

(2012) G. Nicolas et al.   NEUROLOGY

In-vivo evidence for the disruption of Rab11 vesicle transport by loss of huntingtin

(2012) Derek Power et al.   NEUROREPORT

Using non-coding small RNAs to develop therapies for Huntington's disease

(2011) Y Zhang et al.   GENE THERAPY

Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease

(2011) Jodi L McBride et al.   MOLECULAR THERAPY

Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases

(2011) Wei Zheng et al.   PHARMACOLOGY & THERAPEUTICS

Iron Insufficiency Compromises Motor Neurons and Their Mitochondrial Function in Irp2-Null Mice

(2011) Suh Young Jeong et al.   PLoS One

Sustained effects of nonallele-specificHuntingtinsilencing

(2009) Valérie Drouet et al.   ANNALS OF NEUROLOGY

Medium spiny neurons for transplantation in Huntington's disease: Figure 1

(2009) Claire M. Kelly et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

(2009) Ryan L Boudreau et al.   MOLECULAR THERAPY

Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages

(2008) P. Dietrich et al.   HUMAN MOLECULAR GENETICS

Allele-specific silencing of mutant Huntington’s disease gene

(2008) Yu Zhang et al.   JOURNAL OF NEUROCHEMISTRY

A function of huntingtin in guanine nucleotide exchange on Rab11

(2008) Xueyi Li et al.   NEUROREPORT