Widespread epistasis regulates glucose homeostasis and gene expression

Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred Mice

(2017) Anna L. Tyler et al.   GENETICS

Detecting High-Order Epistasis in Nonlinear Genotype-Phenotype Maps

(2017) Zachary R. Sailer et al.   GENETICS

Pervasive antagonistic interactions among hybrid incompatibility loci

(2017) Rafael F. Guerrero et al.   PLoS Genetics

Epistasis and the Evolution of Antimicrobial Resistance

(2017) Alex Wong   Frontiers in Microbiology

Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred Mice

(2017) Anna L. Tyler et al.   GENETICS

Detecting High-Order Epistasis in Nonlinear Genotype-Phenotype Maps

(2017) Zachary R. Sailer et al.   GENETICS

Are Interactions between cis -Regulatory Variants Evidence for Biological Epistasis or Statistical Artifacts?

(2016) Alexandra E. Fish et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genotypic Context and Epistasis in Individuals and Populations

(2016) Timothy B. Sackton et al.   CELL

The biological effects and clinical implications of BRCA mutations: where do we go from here?

(2016) Dominique Stoppa-Lyonnet   EUROPEAN JOURNAL OF HUMAN GENETICS

Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel

(2016) P. N. Gonzalez et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

The Genetic Architecture of Quantitative Traits Cannot Be Inferred from Variance Component Analysis

(2016) Wen Huang et al.   PLoS Genetics

Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium

(2016) Shefali Setia Verma et al.   PLoS Genetics

Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross

(2016) Anna L. Tyler et al.   PLoS Genetics

Contrasting genetic architectures in different mouse reference populations used for studying complex traits

(2015) David A. Buchner et al.   GENOME RESEARCH

Creating reference gene annotation for the mouse C57BL6/J genome assembly

(2015) Jonathan M. Mudge et al.   MAMMALIAN GENOME

Epistatic Interactions in the ArabinoseCis-Regulatory Element

(2015) Mato Lagator et al.   MOLECULAR BIOLOGY AND EVOLUTION

Meta-analysis of the heritability of human traits based on fifty years of twin studies

(2015) Tinca J C Polderman et al.   NATURE GENETICS

Bringing genetic background into focus

(2015) Clement Y. Chow   NATURE REVIEWS GENETICS

Higher-order genetic interactions and their contribution to complex traits

(2015) Matthew B. Taylor et al.   TRENDS IN GENETICS

Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation

(2015) Yufeng Huang et al.   PLoS Genetics

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

RNA-Seq Alignment to Individualized Genomes Improves Transcript Abundance Estimates in Multiparent Populations

(2014) Steven C. Munger et al.   GENETICS

Multiple sclerosis genetics

(2014) Stephen Sawcer et al.   LANCET NEUROLOGY

Detection and replication of epistasis influencing transcription in humans

(2014) Gibran Hemani et al.   NATURE

Another explanation for apparent epistasis

(2014) Andrew R. Wood et al.   NATURE

svaseq: removing batch effects and other unwanted noise from sequencing data

(2014) Jeffrey T. Leek   NUCLEIC ACIDS RESEARCH

Why epistasis is important for tackling complex human disease genetics

(2014) Trudy FC Mackay et al.   Genome Medicine

Genetic architecture of quantitative traits and complex diseases

(2013) Wenqing Fu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

(2013) Z. Kan et al.   GENOME RESEARCH

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma

(2013) Kai Wang et al.   HEPATOLOGY

Epistatic interactions and drug response

(2013) Britta Weigelt et al.   JOURNAL OF PATHOLOGY

An information-gain approach to detecting three-way epistatic interactions in genetic association studies

(2013) Ting Hu et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Finding the sources of missing heritability in a yeast cross

(2013) Joshua S. Bloom et al.   NATURE

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

Epistasis and quantitative traits: using model organisms to study gene–gene interactions

(2013) Trudy F. C. Mackay   NATURE REVIEWS GENETICS

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity

(2012) David A. Buchner et al.   MAMMALIAN GENOME

Chromosome substitution strains: gene discovery, functional analysis, and systems studies

(2012) Joseph H. Nadeau et al.   MAMMALIAN GENOME

Epistasis dominates the genetic architecture of Drosophila quantitative traits

(2012) W. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis

(2011) S. N. Yazbek et al.   GENOME RESEARCH

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

Genome-Wide Interaction-Based Association Analysis Identified Multiple New Susceptibility Loci for Common Diseases

(2011) Yang Liu et al.   PLoS Genetics

Gene–Environment Interactions at Nucleotide Resolution

(2010) Justin Gerke et al.   PLoS Genetics

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Identification of deleterious mutations within three human genomes

(2009) S. Chun et al.   GENOME RESEARCH

Diet-induced hepatocellular carcinoma in genetically predisposed mice

(2009) A. E. Hill-Baskin et al.   HUMAN MOLECULAR GENETICS

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Genetic Interactions Between Transcription Factors Cause Natural Variation in Yeast

(2009) J. Gerke et al.   SCIENCE

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Resistance to diet-induced obesity in mice with a single substituted chromosome

(2008) David A. Buchner et al.   PHYSIOLOGICAL GENOMICS

Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis

(2008) H. Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA