A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds

Elevated levels of epithelial cell transforming sequence 2 predicts poor prognosis for prostate cancer

(2016) Zhenghui Guo et al.   MEDICAL ONCOLOGY

Clinical significance of ECT2 expression in tissue and serum of gastric cancer patients

(2015) H.-B. Wang et al.   Clinical & Translational Oncology

Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome

(2015) Daniel Hartmann et al.   Future Oncology

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition

(2015) Mahito Sadaie et al.   MOLECULAR BIOLOGY OF THE CELL

Genetics of melanoma progression: the rise and fall of cell senescence

(2015) Dorothy C. Bennett   Pigment Cell & Melanoma Research

The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers

(2015) Jun Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks

(2015) Alan E. Bilsland et al.   NEOPLASIA

TCEAL7 Inhibition of c-Myc Activity in Alternative Lengthening of Telomeres Regulates hTERT Expression

(2015) Kyle Lafferty-Whyte et al.   NEOPLASIA

Exploiting tumor cell senescence in anticancer therapy

(2014) Minyoung Lee et al.   BMB Reports

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Gallotannin is a DNA damaging compound that induces senescence independently of p53 and p21 in human colon cancer cells

(2014) Racha Al-Halabi et al.   MOLECULAR CARCINOGENESIS

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Decreased Skp2 Expression Is Necessary but Not Sufficient for Therapy-Induced Senescence in Prostate Cancer

(2014) Jonathan A. Ewald et al.   Translational Oncology

Mathematical Model of a Telomerase Transcriptional Regulatory Network Developed by Cell-Based Screening: Analysis of Inhibitor Effects and Telomerase Expression Mechanisms

(2014) Alan E. Bilsland et al.   PLoS Computational Biology

MiR-223/Ect2/p21 signaling regulates osteosarcoma cell cycle progression and proliferation

(2013) Jianli Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

(2013) D R Cook et al.   ONCOGENE

ECT2 and RASAL2 Mediate Mesenchymal-Amoeboid Transition In Human Astrocytoma Cells

(2012) Adrienne Weeks et al.   AMERICAN JOURNAL OF PATHOLOGY

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

(2012) Michael Steckel et al.   CELL RESEARCH

Cancer cell senescence: a new frontier in drug development

(2012) Claire J. Cairney et al.   DRUG DISCOVERY TODAY

Identification of Mutant K-Ras-dependent Phenotypes Using a Panel of Isogenic Cell Lines

(2012) Steffan Vartanian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells

(2011) E Crescenzi et al.   ONCOGENE

Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma

(2010) Kyle Lafferty-Whyte et al.   BMC GENOMICS

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

(2010) Beate Neumann et al.   NATURE

Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms

(2009) Kyle Lafferty-Whyte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

Dynamic Telomerase Gene Suppression via Network Effects of GSK3 Inhibition

(2009) Alan E. Bilsland et al.   PLoS One

The Guanine Nucleotide Exchange Factors Trio, Ect2, and Vav3 Mediate the Invasive Behavior of Glioblastoma

(2008) Bodour Salhia et al.   AMERICAN JOURNAL OF PATHOLOGY

CUX1 and E2F1 Regulate Coordinated Expression of the Mitotic Complex Genes Ect2, MgcRacGAP, and MKLP1 in S Phase

(2008) L. Seguin et al.   MOLECULAR AND CELLULAR BIOLOGY