Article
Environmental Sciences
Yuehui Liang, Ningjuan Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xiao
Summary: Hexavalent chromium induces senescent hepatocytes to secrete tumor-promoting factors such as IL-6, IL-8, and GM-CSF, with CLU potentially regulating their secretion. NF-kappa B is involved in regulating the tumor-promoting effects of SASP, indicating a potential link to the carcinogenic effects of Cr(VI).
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Lichao Wang, Binsheng Wang, Nathan S. Gasek, Yueying Zhou, Rachel L. Cohn, Dominique E. Martin, Wulin Zuo, William F. Flynn, Chun Guo, Evan R. Jellison, Taewan Kim, Larissa G. P. Langhi Prata, Allyson K. Palmer, Ming Li, Christina L. Inman, Lauren S. Barber, Iman M. A. Al-Naggar, Yanjiao Zhou, Wenqiang Du, Kshitiz, George A. Kuchel, Alexander Meves, Tamar Tchkonia, James L. Kirkland, Paul Robson, Ming Xu
Summary: This study identifies a small population of p21 high-expressing cells that accumulate in adipose tissue with obesity and shows that intermittent clearance of these cells can prevent and alleviate insulin resistance. Inactivation of the NF-kB pathway within these cells attenuates insulin resistance. Additionally, a drug combination of dasatinib and quercetin can eliminate p21 high-expressing cells in human fat and mitigate insulin resistance.
Article
Biochemistry & Molecular Biology
Huakang Zhou, Dilaware Khan, Norbert Gerdes, Carsten Hagenbeck, Majeed Rana, Jan Frederick Cornelius, Sajjad Muhammad
Summary: Inflammaging is a potential risk factor for cardiovascular diseases, leading to the development of thrombosis and atherosclerosis. Ethanol can induce inflammation and senescence, which are both implicated in cardiovascular diseases. In this study, colchicine was used to mitigate the damaging effects of ethanol on endothelial cells. It prevented senescence, reduced oxidative stress, and inhibited the activation of NF-κB and MAPKs in ethanol-treated endothelial cells. Colchicine ameliorated the ethanol-induced molecular events, resulting in attenuated senescence and senescence-associated secretory phenotype in endothelial cells.
Article
Fisheries
Yuan Song, Ryuji Okazaki, Yasuhiro Yoshida
Summary: The study revealed that mice exposed to radiation at a young age exhibited increased expression and phosphorylation of certain molecules in splenocytes, along with a NF-kappa B-related immune response and elevated levels of senescence marker proteins like CDKs and IL-6. This suggests that radiation-induced cellular senescence in the spleen involves DNA damage-related stress responses, potentially contributing to aging.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Priyanka Banerjee, Sivareddy Kotla, Loka Reddy Velatooru, Rei J. Abe, Elizabeth A. Davis, John P. Cooke, Keri Schadler, Anita Deswal, Joerg Herrmann, Steven H. Lin, Jun-ichi Abe, Nhat-Tu Le
Summary: Cellular senescence plays a crucial role in the development of cancer and cardiovascular diseases, particularly at the intersection between the two. The senescence-associated secretory phenotype (SASP) of senescent cells is a common factor in both cancer and CVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Kelly E. Leon, Raquel Buj, Elizabeth Lesko, Erika S. Dahl, Chi-Wei Chen, Naveen Kumar Tangudu, Yuka Imamura-Kawasawa, Andrew Kossenkov, Ryan P. Hobbs, Katherine M. Aird
Summary: Oncogene-induced senescence (OIS) is a stable cell cycle arrest that occurs in normal cells upon oncogene activation. The expression of DOT1L has been identified as an epigenetic regulator of the SASP, providing a potential strategy to inhibit the negative side effects of senescence while maintaining the beneficial inhibition of proliferation.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Laura Sole, Teresa Lobo-Jarne, Daniel Alvarez-Villanueva, Josune Alonso-Maranon, Yolanda Guillen, Marta Guix, Irene Sangrador, Catalina Rozalen, Anna Vert, Antonio Barbachano, Joan Lop, Marta Salido, Beatriz Bellosillo, Raquel Garcia-Romero, Marta Garrido, Jessica Gonzalez, Maria Martinez-Iniesta, Erika Lopez-Arribillaga, Ramon Salazar, Clara Montagut, Ferran Torres, Mar Iglesias, Toni Celia-Terrassa, Alberto Munoz, Alberto Villanueva, Anna Bigas, Lluis Espinosa
Summary: This study reveals that sub-lethal dose of chemotherapy induces a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state in wild-type p53 colorectal cancers, which is associated with higher metastatic activity and poor prognosis in patients.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Ruihong Lan, Yang Yang, Jie Song, Ling Wang, Humin Gong
Summary: The overexpression of Fas promotes apoptosis, suppresses viability, and impairs migration of human trophoblast cells, while the knockdown of Fas reduces apoptosis, increases viability, and enhances migration. Fas regulates trophoblast cell apoptosis and migration by targeting NF-kappa B.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Geriatrics & Gerontology
Yaqun Huang, Ming-Xia Ge, Yu-Hong Li, Jing-Lin Li, Qin Yu, Fu-Hui Xiao, Hong-Shun Ao, Li-Qin Yang, Ji Li, Yonghan He, Qing-Peng Kong
Summary: This study found that long-lived individuals have lower inflammation levels and higher expression of ATF7. Loss of ATF7 leads to cellular senescence, while its overexpression delays senescence progress and secretion of senescence-associated secretory phenotype. These findings suggest that ATF7 is a longevity-promoting factor that lowers cellular senescence and inflammation in long-lived individuals.
Article
Geriatrics & Gerontology
Yaqun Huang, Ming-Xia Ge, Yu-Hong Li, Jing-Lin Li, Qin Yu, Fu-Hui Xiao, Hong-Shun Ao, Li-Qin Yang, Ji Li, Yonghan He, Qing-Peng Kong
Summary: This study found that long-lived individuals have lower inflammation levels and up-regulation of ATF7. Overexpression of ATF7 can delay cellular senescence and inhibit inflammation, thus promoting longevity.
Article
Multidisciplinary Sciences
Marta Montes, Michal Lubas, Frederic S. Arendrup, Bettina Mentz, Neha Rohatgi, Sarunas Tumas, Lea M. Harder, Anders J. Skanderup, Jens S. Andersen, Anders H. Lund
Summary: The long non-coding RNA MIR31HG was shown to regulate the expression and secretion of a subset of SASP components that induce paracrine invasion through interaction with YBX1 and induction of IL1A translation.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Yu Xiao, Jiaqi Liang, Kenneth W. Witwer, Ying Zhang, Qian Wang, Hang Yin
Summary: In our study, we discovered that extracellular vesicles (EVs) play a crucial role in aging, as they can induce chronic inflammation by activating immune cells. We found that EVs derived from senescent cells contain miR-30b-5p, which downregulates SIRT1 and enhances pro-inflammatory cytokine production. Additionally, we observed increased levels of miR-30b-5p in both the aging animal model and EVs harvested from tissues. EVs carrying pro-inflammatory signals can alter immune cell activity in the aging microenvironment, leading to an increase in inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Runjiu Zhu, Haoyang Wan, Hong Yang, Mingrui Song, Yu Chai, Bin Yu
Summary: With the increasing proportion of older individuals in most countries, the prevalence of osteoporosis has been on the rise, leading scientists to focus on the pathogenic mechanisms of this condition. In recent years, research on cellular senescence has shed light on the role of the senescent microenvironment in osteoporosis. Senescent cells in the bone marrow secrete senescence-associated secretory phenotype (SASP) factors, which can impact both their own function and the surrounding healthy cells, exacerbating the aging process. The composition of SASP may vary depending on the cause of osteoporosis. This review summarizes the relationship between SASP factors and osteoporosis and provides new insights for the investigation of its mechanism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Li Gao, Wen-ge Zheng, Xing-kang Wu, Guan-hua Du, Xue-mei Qin
Summary: Baicalein, extracted from Scutellaria baicalensis, has shown protective effects against astrocyte senescence through regulation of leucine metabolism, suppression of SASP secretion, and inhibition of NF-kappa B and JAK2/STAT1 pathways. Experiment results in T98G cells and primary astrocytes of newborn SD rats support its potential in delaying senescence and enhancing cell viabilities.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Hyun-Jung Kim, Woo-Jin Kim, Hye-Rim Shin, Hee-In Yoon, Jae- Moon, Eunji Lee, Jin-Muk Lim, Young-Dan Cho, Mi-Hye Lee, Hong-Gee Kim, Hyun-Mo Ryoo
Summary: Cellular senescence is closely related to tissue aging, including bone. Oxidative stress caused by the accumulation of reactive oxygen species (ROS) accelerates cellular senescence and dysfunction of osteoblasts. This study identified PADI2 as a regulator of ROS-accelerated senescence of osteoblasts and provided new insights into excessive ROS-promoted cellular senescence and aging-related bone diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Letter
Hematology
Laura Tornatore, Daria Capece, Daniel D'Andrea, Federica Begalli, Daniela Verzella, Jason Bennett, Gary Acton, Elizabeth A. Campbell, James Kelly, Michael Tarbit, Nigel Adams, Selina Bannoo, Antonio Leonardi, Annamaria Sandomenico, Domenico Raimondo, Menotti Ruvo, Angela Chambery, Metod Oblak, Magda J. Al-Obaidi, Richard S. Kaczmarski, Ian Gabriel, Heather E. Oakervee, Martin F. Kaiser, Ashutosh Wechalekar, Reuben Benjamin, Jane F. Apperley, Holger W. Auner, Guido Franzoso
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Multidisciplinary Sciences
Giusi Barra, Alessio Lepore, Miriam Gagliardi, Domenico Somma, Maria Rosaria Matarazzo, Francesca Costabile, Giuseppe Pasquale, Alessio Mazzoni, Carmela Gallo, Genoveffa Nuzzo, Francesco Annunziato, Angelo Fontana, Antonio Leonardi, Raffaele De Palma
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Francesco Pacifico, Nadia Badolati, Stefano Mellone, Mariano Stornaiuolo, Antonio Leonardi, Elvira Crescenzi
Summary: The study reveals that cancer cells escaping therapy-induced senescence rely on glutamine, which provides nitrogen for cell proliferation and plays a crucial role in other metabolic and non-metabolic pathways. This metabolic vulnerability of cancer stem cells recovering after exposure to anticancer therapies could be targeted to prevent tumor recurrence.
Review
Biochemistry & Molecular Biology
Elvira Crescenzi, Antonio Leonardi, Francesco Pacifico
Summary: The review focuses on the different roles of NGAL in the tumor microenvironment and in cancer senescence-associated secretory phenotype (SASP), highlighting the most crucial functions that could be eventually targetable in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Caterina Miro, Angelo Di Giovanni, Melania Murolo, Annunziata Gaetana Cicatiello, Annarita Nappi, Serena Sagliocchi, Emery Di Cicco, Francesco Morra, Angela Celetti, Francesco Pacifico, Ciro Imbimbo, Felice Crocetto, Monica Dentice
Summary: Thyroid hormones play a crucial role in the formation and progression of prostate cancer, interacting with androgens to promote tumor proliferation and inflammation.
Article
Pharmacology & Pharmacy
Francesco Pacifico, Stefano Mellone, Maurizio D'Incalci, Mariano Stornaiuolo, Antonio Leonardi, Elvira Crescenzi
Summary: This study reveals that the antineoplastic drug trabectedin can suppress the escape of cancer cells from therapy-induced senescence and reduce the population of cancer stem cells. Trabectedin exerts its effect by interfering with glutamine metabolism.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesco Pacifico, Antonio Leonardi, Elvira Crescenzi
Summary: In this review, we explore the role of glutamine in controlling the fate of cancer stem cells (CSCs). We provide an overview of glutamine metabolism and summarize relevant studies on how it affects CSCs in solid tumors. Glutamine in CSCs contributes to various metabolic pathways and plays a key role in epigenetic modifications. The tumor microenvironment, including cancer-associated fibroblasts, adipocytes, and senescent cells, can indirectly influence CSC fate through modulation of glutamine availability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Jwala P. Sivaccumar, Emanuela Iaccarino, Angela Oliver, Maria Cantile, Pierpaolo Olimpieri, Antonio Leonardi, Menotti Ruvo, Annamaria Sandomenico
Summary: Drug development has shifted toward personalized treatments targeting specific therapeutic targets in individual patients. Monoclonal antibodies (mAbs) and their surrogates, such as Fabs, are increasingly used for their ability to bind and inhibit therapeutic targets. In this study, a recombinant humanized Fab of a murine mAb (3D1) was prepared and characterized, showing potential for targeting Nodal-positive cancer cells.
Review
Biology
Elvira Crescenzi, Antonio Leonardi, Francesco Pacifico
Summary: Iron is an essential element in human cells, involved in various processes. Dysregulation of iron metabolism has been observed in cancer cells and senescent cells, promoting tumor growth and aging. Therefore, targeting iron metabolism may be a potential strategy for cancer therapy and aging research.
Article
Biochemistry & Molecular Biology
Luisa Calvanese, Annalia Foca, Annamaria Sandomenico, Giuseppina Foca, Andrea Caporale, Nunzianna Doti, Emanuela Iaccarino, Antonio Leonardi, Gabriella D'Auria, Menotti Ruvo, Lucia Falcigno
BIOORGANIC & MEDICINAL CHEMISTRY
(2017)