Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

(2016) Maria Secrier et al.   NATURE GENETICS

The healthy human microbiome

(2016) Jason Lloyd-Price et al.   Genome Medicine

Manta: rapid detection of structural variants and indels for germline and cancer sequencing applications

(2015) Xiaoyu Chen et al.   BIOINFORMATICS

Determination of the Relationship Between rs4986790 and rs4986791 Variants of TLR4 Gene and Lung Cancer

(2015) Hulyam Kurt et al.   INFLAMMATION

Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer

(2015) Bogdan I. Fedeles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Composition of the Human Upper Gastrointestinal Tract Microbiome Is Dynamic and Associated with Genomic Instability in a Barrett’s Esophagus Cohort

(2015) Alevtina Gall et al.   PLoS One

Association ofHelicobacter pyloriinfection with esophageal adenocarcinoma and squamous cell carcinoma: a meta-analysis

(2014) S. Nie et al.   DISEASES OF THE ESOPHAGUS

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis

(2014) Jamie M J Weaver et al.   NATURE GENETICS

The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane

(2014) A. Liaunardy-Jopeace et al.   Science Signaling

Oesophageal bacterial biofilm changes in gastro-oesophageal reflux disease, Barrett's and oesophageal carcinoma: association or causality?

(2013) K. L. Blackett et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

(2013) Dan A. Landau et al.   CELL

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

(2013) Austin M Dulak et al.   NATURE GENETICS

Constitutive TLR4 signalling in intestinal epithelium reduces tumor load by increasing apoptosis in APCMin/+ mice

(2013) Y Li et al.   ONCOGENE

Helicobacter pyloriinfection and esophageal cancer risk: An updated meta-analysis

(2013) Fa-Jun Xie   WORLD JOURNAL OF GASTROENTEROLOGY

Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs

(2012) Christopher T. Saunders et al.   BIOINFORMATICS

Barrett’s to Oesophageal Cancer Sequence: A Model of Inflammatory-Driven Upper Gastrointestinal Cancer

(2012) Sarah L. Picardo et al.   DIGESTIVE SURGERY

MuSiC: Identifying mutational significance in cancer genomes

(2012) N. D. Dees et al.   GENOME RESEARCH

Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I

(2012) Umeharu Ohto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

(2012) Paras K. Anand et al.   NATURE

Inflammation and Barrett's carcinogenesis

(2012) A. Poehlmann et al.   PATHOLOGY RESEARCH AND PRACTICE

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

PathScan: a tool for discerning mutational significance in groups of putative cancer genes

(2011) Michael C. Wendl et al.   BIOINFORMATICS

SomaticSniper: identification of somatic point mutations in whole genome sequencing data

(2011) David E. Larson et al.   BIOINFORMATICS

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

PathSeq: software to identify or discover microbes by deep sequencing of human tissue

(2011) Aleksandar D Kostic et al.   NATURE BIOTECHNOLOGY

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

(2011) S. Normand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PyRosetta: a script-based interface for implementing molecular modeling algorithms using Rosetta

(2010) S. Chaudhury et al.   BIOINFORMATICS

Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor

(2010) William McLaren et al.   BIOINFORMATICS

Fast and accurate long-read alignment with Burrows–Wheeler transform

(2010) Heng Li et al.   BIOINFORMATICS

Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line

(2010) Alvarez Hector et al.   CANCER BIOLOGY & THERAPY

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis

(2010) Masayuki Fukata et al.   INFLAMMATORY BOWEL DISEASES

Allele-specific copy number analysis of tumors

(2010) P. Van Loo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and Intestinal Metaplasia of the Distal Esophagus Are Associated With Alterations in the Microbiome

(2009) Liying Yang et al.   GASTROENTEROLOGY

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY