The genotype-phenotype map of an evolving digital organism

Genetic Correlations Greatly Increase Mutational Robustness and Can Both Reduce and Enhance Evolvability

(2016) Sam F. Greenbury et al.   PLoS Computational Biology

The organization of biological sequences into constrained and unconstrained parts determines fundamental properties of genotype–phenotype maps

(2015) S. F. Greenbury et al.   Journal of the Royal Society Interface

Contingency and entrenchment in protein evolution under purifying selection

(2015) Premal Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exhaustive Analysis of a Genotype Space Comprising 1015 Central Carbon Metabolisms Reveals an Organization Conducive to Metabolic Innovation

(2015) Sayed-Rzgar Hosseini et al.   PLoS Computational Biology

Properties of selected mutations and genotypic landscapes under Fisher's geometric model

(2014) François Blanquart et al.   EVOLUTION

Not all roads can be taken: development induces anisotropic accessibility in morphospace

(2014) Sylvain Gerber   EVOLUTION & DEVELOPMENT

Engineering reduced evolutionary potential for synthetic biology

(2014) Brian A. Renda et al.   Molecular BioSystems

Cryptic genetic variation: evolution's hidden substrate

(2014) Annalise B. Paaby et al.   NATURE REVIEWS GENETICS

The Arrival of the Frequent: How Bias in Genotype-Phenotype Maps Can Steer Populations to Local Optima

(2014) Steffen Schaper et al.   PLoS One

The Robustness and Evolvability of Transcription Factor Binding Sites

(2014) J. L. Payne et al.   SCIENCE

A unified design space of synthetic stripe-forming networks

(2014) Yolanda Schaerli et al.   Nature Communications

toyLIFE: a computational framework to study the multi-level organisation of the genotype-phenotype map

(2014) Clemente F. Arias et al.   Scientific Reports

SELECTION BIASES THE PREVALENCE AND TYPE OF EPISTASIS ALONG ADAPTIVE TRAJECTORIES

(2013) Jeremy A. Draghi et al.   EVOLUTION

Adaptive dynamics under development-based genotype–phenotype maps

(2013) Isaac Salazar-Ciudad et al.   NATURE

A latent capacity for evolutionary innovation through exaptation in metabolic systems

(2013) Aditya Barve et al.   NATURE

Understanding Evolutionary Potential in Virtual CPU Instruction Set Architectures

(2013) David M. Bryson et al.   PLoS One

Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme

(2011) Eric J. Hayden et al.   NATURE

Experimental illumination of a fitness landscape

(2011) R. T. Hietpas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Genotype networks in metabolic reaction spaces

(2010) Areejit Samal et al.   BMC Systems Biology

Mutational robustness can facilitate adaptation

(2010) Jeremy A. Draghi et al.   NATURE

Robustness and Evolvability

(2010) Joanna Masel et al.   TRENDS IN GENETICS

A GENERAL FRAMEWORK FOR THE ANALYSIS OF PHENOTYPIC TRAJECTORIES IN EVOLUTIONARY STUDIES

(2009) Dean C. Adams et al.   EVOLUTION

Evolutionary Plasticity and Innovations in Complex Metabolic Reaction Networks

(2009) João F. Matias Rodrigues et al.   PLoS Computational Biology

On the Gradual Evolution of Complexity and the Sudden Emergence of Complex Features

(2008) Charles Ofria et al.   ARTIFICIAL LIFE

Harnessing Digital Evolution

(2008) P. McKinley et al.   COMPUTER

Neutralism and selectionism: a network-based reconciliation

(2008) Andreas Wagner   NATURE REVIEWS GENETICS

The Ascent of the Abundant: How Mutational Networks Constrain Evolution

(2008) Matthew C. Cowperthwaite et al.   PLoS Computational Biology

Discovering Sequence Motifs with Arbitrary Insertions and Deletions

(2008) Martin C. Frith et al.   PLoS Computational Biology

Robustness and evolvability: a paradox resolved

(2007) A. Wagner   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES