Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks

Comparative genome-scale modelling ofStaphylococcus aureusstrains identifies strain-specific metabolic capabilities linked to pathogenicity

(2016) Emanuele Bosi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Scale Vector Resource Enables High-Throughput Reverse Genetic Screening in a Malaria Parasite

(2015) Ana Rita Gomes et al.   Cell Host & Microbe

Heading in the right direction: thermodynamics-based network analysis and pathway engineering

(2015) Meric Ataman et al.   CURRENT OPINION IN BIOTECHNOLOGY

Targeting the intersubunit cavity of Plasmodium falciparum glutathione reductase by a novel natural inhibitor: Computational and experimental evidence

(2015) Chetna Tyagi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites

(2015) Frank Schwach et al.   NUCLEIC ACIDS RESEARCH

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

(2015) Stepan Tymoshenko et al.   PLoS Computational Biology

Plasmodium IspD (2-C-Methyl-d-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target

(2015) Leah S. Imlay et al.   ACS Infectious Diseases

1H-NMR metabolite profiles of different strains ofPlasmodium falciparum

(2014) Rongwei Teng et al.   BIOSCIENCE REPORTS

Modeling metabolism and stage-specific growth of Plasmodium falciparum HB3 during the intraerythrocytic developmental cycle

(2014) Xin Fang et al.   Molecular BioSystems

Targeting NAD+ Metabolism in the Human Malaria Parasite Plasmodium falciparum

(2014) Jessica K. O'Hara et al.   PLoS One

BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

(2014) Rebecca D. Oppenheim et al.   PLoS Pathogens

Reduced glycerol incorporation into phospholipids contributes to impaired intra-erythrocytic growth of glycerol kinase knockout Plasmodium falciparum parasites

(2013) Kubendran Naidoo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Towards kinetic modeling of genome-scale metabolic networks without sacrificing stoichiometric, thermodynamic and physiological constraints

(2013) Anirikh Chakrabarti et al.   Biotechnology Journal

Functional genomics of Plasmodium falciparum using metabolic modelling and analysis

(2013) S. Tymoshenko et al.   Briefings in Functional Genomics

Biosynthesis of GDP-fucose and Other Sugar Nucleotides in the Blood Stages ofPlasmodium falciparum

(2013) Sílvia Sanz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights Gained fromP. falciparumCultivation in Modified Media

(2013) Sanjay A. Desai   TheScientificWorldJOURNAL

The RAVEN Toolbox and Its Use for Generating a Genome-scale Metabolic Model for Penicillium chrysogenum

(2013) Rasmus Agren et al.   PLoS Computational Biology

A quantitative liquid chromatography tandem mass spectrometry method for metabolomic analysis of Plasmodium falciparum lipid related metabolites

(2012) S. Vo Duy et al.   ANALYTICA CHIMICA ACTA

Purine and Pyrimidine Pathways as Targets in Plasmodium falciparum

(2011) Maria Belen Cassera et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

From network models to network responses: integration of thermodynamic and kinetic properties of yeast genome-scale metabolic networks

(2011) Keng Cher Soh et al.   FEMS YEAST RESEARCH

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

(2011) Ellen Yeh et al.   PLOS BIOLOGY

Thermodynamic Calculations for Biochemical Transport and Reaction Processes in Metabolic Networks

(2010) Stefan J. Jol et al.   BIOPHYSICAL JOURNAL

Network thermodynamics in the post-genomic era

(2010) Keng Cher Soh et al.   CURRENT OPINION IN MICROBIOLOGY

The Kennedy phospholipid biosynthesis pathways are refractory to genetic disruption in Plasmodium berghei and therefore appear essential in blood stages

(2010) Sandrine Déchamps et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

New insights into the blood-stage transcriptome ofPlasmodium falciparumusing RNA-Seq

(2010) Thomas D. Otto et al.   MOLECULAR MICROBIOLOGY

What is flux balance analysis?

(2010) Jeffrey D Orth et al.   NATURE BIOTECHNOLOGY

A protocol for generating a high-quality genome-scale metabolic reconstruction

(2010) Ines Thiele et al.   Nature Protocols

Dihydroorotase from the HyperthermophileAquifiex aeolicusIs Activated by Stoichiometric Association with Aspartate Transcarbamoylase and Forms a One-Pot Reactor for Pyrimidine Biosynthesis†‡

(2009) Pengfei Zhang et al.   BIOCHEMISTRY

Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene

(2009) Audrey R. Odom et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Group Contribution Method for Thermodynamic Analysis of Complex Metabolic Networks

(2008) Matthew D. Jankowski et al.   BIOPHYSICAL JOURNAL

Metabolite profiling of the intraerythrocytic malaria parasitePlasmodium falciparumby1H NMR spectroscopy

(2008) Rongwei Teng et al.   NMR IN BIOMEDICINE

Dihydroorotase of human malarial parasite Plasmodium falciparum differs from host enzyme

(2007) Sudaratana R. Krungkrai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS