Alteration of protein function by a silent polymorphism linked to tRNA abundance

Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator

(2016) Zhe Zhang et al.   CELL

Quality over quantity: optimizing co-translational protein folding with non-‘optimal’ synonymous codons

(2016) Giselle N Jacobson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator

(2016) Vedrana Bali et al.   FASEB JOURNAL

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

(2016) Gudio Veit et al.   MOLECULAR BIOLOGY OF THE CELL

Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations

(2016) Florian Buhr et al.   MOLECULAR CELL

Clarifying the Translational Pausing Landscape in Bacteria by Ribosome Profiling

(2016) Fuad Mohammad et al.   Cell Reports

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

(2016) Guido Veit et al.   PLOS BIOLOGY

Pausing on Polyribosomes: Make Way for Elongation in Translational Control

(2015) Joel D. Richter et al.   CELL

Synonymous Codon Usage Affects the Expression of Wild Type and F508del CFTR

(2015) Kalpit Shah et al.   JOURNAL OF MOLECULAR BIOLOGY

Impact of the F508del mutation on ovine CFTR, a Cl−channel with enhanced conductance and ATP-dependent gating

(2015) Zhiwei Cai et al.   JOURNAL OF PHYSIOLOGY-LONDON

Codon Usage Influences the Local Rate of Translation Elongation to Regulate Co-translational Protein Folding

(2015) Chien-Hung Yu et al.   MOLECULAR CELL

Translational tuning optimizes nascent protein folding in cells

(2015) S. J. Kim et al.   SCIENCE

Synthesis at the Speed of Codons

(2015) Kristin S. Koutmou et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

(2014) Hila Gingold et al.   CELL

Expanding Anfinsen’s Principle: Contributions of Synonymous Codon Selection to Rational Protein Design

(2014) Ian M. Sander et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation

(2014) C. Pop et al.   Molecular Systems Biology

Ribosome profiling: new views of translation, from single codons to genome scale

(2014) Nicholas T. Ingolia   NATURE REVIEWS GENETICS

Cystic fibrosis genetics: from molecular understanding to clinical application

(2014) Garry R. Cutting   NATURE REVIEWS GENETICS

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease

(2014) Sebastian Kirchner et al.   NATURE REVIEWS GENETICS

Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

(2014) R. Ishimura et al.   SCIENCE

Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments

(2014) Liana F Lareau et al.   eLife

Assessing the residual CFTR gene expression in human nasal epithelium cells bearing CFTR splicing mutations causing cystic fibrosis

(2013) Laia Masvidal et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Structural changes of CFTR R region upon phosphorylation: a plastic platform for intramolecular and intermolecular interactions

(2013) Zoltan Bozoky et al.   FEBS Journal

Combined Computational-Experimental Analyses ofCFTRExon Strength Uncover Predictability of Exon-Skipping Level

(2013) Abdel Aissat et al.   HUMAN MUTATION

Non-optimal codon usage affects expression, structure and function of clock protein FRQ

(2013) Mian Zhou et al.   NATURE

Non-optimal codon usage is a mechanism to achieve circadian clock conditionality

(2013) Yao Xu et al.   NATURE

Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences

(2012) Juan L. Mendoza et al.   CELL

Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function

(2012) Wael M. Rabeh et al.   CELL

CFTR,SPINK1,CTRCandPRSS1variants in chronic pancreatitis: is the role of mutatedCFTRoverestimated?

(2012) Jonas Rosendahl et al.   GUT

Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation

(2012) Kang-Yang Jih et al.   JOURNAL OF GENERAL PHYSIOLOGY

Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis

(2012) Xiubin Liang et al.   MOLECULAR BIOLOGY OF THE CELL

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Genetic Variation and Clinical Heterogeneity in Cystic Fibrosis

(2011) Mitchell L. Drumm et al.   Annual Review of Pathology-Mechanisms of Disease

Recommendations for the classification of diseases as CFTR-related disorders

(2011) C. Bombieri et al.   Journal of Cystic Fibrosis

Understanding the contribution of synonymous mutations to human disease

(2011) Zuben E. Sauna et al.   NATURE REVIEWS GENETICS

A Synonymous Single Nucleotide Polymorphism in ΔF508CFTRAlters the Secondary Structure of the mRNA and the Expression of the Mutant Protein

(2010) Rafal A. Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cystic Fibrosis-causing Mutation ΔF508 Affects Multiple Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis

(2010) Patrick H. Thibodeau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

Synonymous but not the same: the causes and consequences of codon bias

(2010) Joshua B. Plotkin et al.   NATURE REVIEWS GENETICS

Independent Contribution of Common CFTR Variants to Chronic Pancreatitis

(2010) Rafael de Cid et al.   PANCREAS

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

(2010) T. Okiyoneda et al.   SCIENCE

Alternative Splicing at a NAGNAG Acceptor Site as a Novel Phenotype Modifier

(2010) Alexandre Hinzpeter et al.   PLoS Genetics

Molecular models of the open and closed states of the whole human CFTR protein

(2009) Jean-Paul Mornon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cooperative Assembly and Misfolding of CFTR Domains In Vivo

(2009) Kai Du et al.   MOLECULAR BIOLOGY OF THE CELL

Transient ribosomal attenuation coordinates protein synthesis and co-translational folding

(2009) Gong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Virus Attenuation by Genome-Scale Changes in Codon Pair Bias

(2008) J. R. Coleman et al.   SCIENCE

Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome

(2008) Adam R. Boyko et al.   PLoS Genetics