期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2015, 期 25, 页码 5546-5553出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201500630
关键词
Nickel; Biaryls; Esters; Cross-coupling; Decarbonylation
资金
- University of British Columbia (UBC)
- Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery
- Research Tools and Instrument (RTI) Grant Program
- Collaborative Research and Training Experience Program (CREATE) program
A variety of functionalized biaryls can be accessed by coupling aryl and heteroaryl esters with boronic acids in Suzuki-Miyaura-type decarbonylative cross-coupling catalyzed by an affordable catalyst system composed of Ni(cod)(2) and PCy3. The methodology is tolerant of a variety of functional groups and presents an attractive alternative to the use of palladium catalysis currently used in industry to acquire such bis(hetero)aryls, but also reveals challenges associated with nickel catalysis of esters in cross-coupling chemistry.
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