Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carb­oxylic Acid Amides and the Expensive Drug Ivacaftor

Ozonolysis of Unsaturated Compounds in the Synthesis of Insect Pheromones and Juvenoids

(2015) G. Yu. Ishmuratov et al.   CHEMISTRY OF NATURAL COMPOUNDS

Origins of the Quinolone Class of Antibacterials: An Expanded “Discovery Story”

(2015) Gregory S. Bisacchi   JOURNAL OF MEDICINAL CHEMISTRY

Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine E, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines A and C

(2015) Zhengren Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expeditious Synthesis of Ivacaftor

(2014) Jingshan Shen et al.   HETEROCYCLES

Discovery of N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator

(2014) Sabine Hadida et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery Heralds New Approach to the Treatment of Cystic Fibrosis

(2014) John A. Lowe   JOURNAL OF MEDICINAL CHEMISTRY

4-Quinolone Alkaloids from Melochia odorata

(2014) Raquel C. Jadulco et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis, Cytotoxicity and Mechanistic Evaluation of 4-Oxoquinoline-3-carboxamide Derivatives: Finding New Potential Anticancer Drugs

(2014) Luana Forezi et al.   MOLECULES

Total Synthesis of Deoxy-solomonamide B by Mimicking Biogenesis

(2014) N. Vasudevan et al.   ORGANIC LETTERS

Synthesis of Akt Inhibitor Ipatasertib. Part 1. Route Scouting and Early Process Development of a Challenging Cyclopentylpyrimidine Intermediate

(2014) Jonathan W. Lane et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Pharmacoeconomics and the Medicinal Chemist

(2014) Craig W. Lindsley   ACS Medicinal Chemistry Letters

Synthesis of Intervenolin, an Antitumor Natural Quinolone with Unusual Substituents

(2013) Hikaru Abe et al.   ORGANIC LETTERS

7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as Selective CB2 Cannabinoid Receptor Ligands: Structural Investigations around a Novel Class of Full Agonists

(2012) Pier Giovanni Baraldi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure–Activity Relationships of New Quinolone-Type Molecules against Trypanosoma brucei

(2012) Georg Hiltensperger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mild and Efficient Winterfeldt Oxidation of 1,2,3,4-Tetrahydro-γ-carbolines for the Synthesis of Dihydropyrrolo[3,2-b]-quinolones and Pyrrolo[3,2-b]quinolones

(2012) Rong Sheng et al.   MOLECULES

Ivacaftor

(2012) Pamela B. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Pyridine Is an Organocatalyst for the Reductive Ozonolysis of Alkenes

(2012) Rachel Willand-Charnley et al.   ORGANIC LETTERS

A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid

(2012) Claudio Battilocchio et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Intramolecular N-aza-amidoalkylation in association with Witkop–Winterfeldt oxidation as the key step to synthesize Luotonin-A analogues

(2011) Frédéric Pin et al.   TETRAHEDRON

4-Quinolones: Smart Phones of the Microbial World

(2010) Holly Huse et al.   CHEMICAL REVIEWS

Structure-Activity Relationship Refinement and Further Assessment of Indole-3-glyoxylamides as a Lead Series against Prion Disease

(2010) Mark J. Thompson et al.   ChemMedChem

Voreloxin, a First-in-Class Anticancer Quinolone Derivative, in Relapsed/Refractory Solid Tumors: A Report on Two Dosing Schedules

(2010) R. H. Advani et al.   CLINICAL CANCER RESEARCH

Development of an Early Enabling Synthesis for PF-03052334-02: A Novel Hepatoselective HMG-CoA Reductase Inhibitor

(2010) Daniel M. Bowles et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The Witkop–Winterfeldt oxidation converts tetrahydropyridoindoles into pyrroloquinolones and cinnolines by an unprecedented scaffold rearrangement

(2010) Matthias Mentel et al.   TETRAHEDRON

Stereoselective Synthesis of (+)-Euphococcinine and (−)-Adaline

(2009) Mélissa Arbour et al.   JOURNAL OF ORGANIC CHEMISTRY

Conjugate Addition−Dipolar Cycloaddition Cascade for the Synthesis of Benzo[a]quinolizine and Indolo[a]quinolizine Scaffolds: Application to the Total Synthesis of (±)-Yohimbenone

(2009) Chad J. Stearman et al.   JOURNAL OF ORGANIC CHEMISTRY

Development and Large-Scale Preparation of an Oral TACE Inhibitor

(2009) Scott A. Savage et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

An Ozonolysis−Reduction Sequence for the Synthesis of Pharmaceutical Intermediates in Microstructured Devices

(2009) Sandra Hübner et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

(2009) L. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA