期刊
ORGANIC LETTERS
卷 15, 期 9, 页码 2124-2127出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol400587a
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资金
- Grants-in-Aid for Scientific Research [23501321] Funding Source: KAKEN
Synthesis of intervenolin, a natural quinolone discovered by screening for selective growth inhibitors of cancer cells cocultured with stromal cells over monocultured cells, was achieved. The synthesis utilized a thiocyanate-isothiocyanate rearrangement and Suzuki-Miyaura coupling to furnish the characteristic substituents, the iminodithiocarbonate moiety, and the geranyl side chain, respectively. In vivo studies showed that intervenolin inhibited tumor tissue growth in model mice.
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