Review
Biochemistry & Molecular Biology
Marcelino Perez-Bermejo, Irene Mas-Perez, Maria Teresa Murillo-Llorente
Summary: Bisphenol A, a common endocrine disruptor found in daily products, is linked to obesity and diabetes due to its ability to mimic natural estrogen. This compound can stimulate adipocyte hypertrophy and alter the endocrine system. Despite some countries implementing policies, there is a lack of international agreement on the regulation of Bisphenol A exposure.
Article
Environmental Sciences
Inae Lee, Young Joo Park, Min Joo Kim, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Kyungho Choi, Min Kyong Moon
Summary: This study in the adult Korean population found that the direction of associations between exposure to phthalates, BPA, and parabens and obesity and diabetes mellitus varied depending on the method used to adjust urinary dilution. It highlights the importance of choosing an appropriate adjustment method when studying the associations between these chemical exposures and health outcomes. Further research in other populations is needed to confirm these findings.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Julie Delepierre, Sandrine Fosse-Edorh, Clemence Fillol, Clara Piffaretti
Summary: Recent international research has shown that exposure to bisphenol A (BPA) may increase the risk of diabetes, but limited results are available for exposure to bisphenol S (BPS) and bisphenol F (BPF). This study aimed to examine the relationships between impregnation with BPA, BPS, and BPF and the prevalence of diabetes or prediabetes in the French adult population. The results showed that a higher urinary BPA concentration was associated with a higher prevalence of diabetes or prediabetes, independent of known risk factors for diabetes, while urinary BPS and BPF concentrations did not show a significant association.
Review
Endocrinology & Metabolism
Shane V. Varghese, Julianne M. Hall
Summary: The prevalence of obesity has increased significantly in recent decades, with endocrine disruptors like Bisphenol A (BPA) and its substitutes being identified as potential obesogens. This review aims to investigate the relationship between BPA substitutes and obesity. Evidence suggests that BPA substitutes, such as BPS, may act as obesogens at the pathophysiological level, while the evidence for BPF and BPAF is inconclusive.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Environmental Sciences
Hend F. Alharbi, Raya Algonaiman, Rana Alduwayghiri, Thamer Aljutaily, Reham M. Algheshairy, Abdulkarim S. Almutairi, Razan M. Alharbi, Leena A. Alfurayh, Amjad A. Alshahwan, Amjad F. Alsadun, Hassan Barakat
Summary: This article reviews the association between the urinary concentrations of bisphenol S (BPS) and/or bisphenol F (BPF) and the incidence of obesity and diabetes. The results show that BPS is associated with obesity at relatively high concentrations and may be associated with diabetes at lower concentrations. Limited studies have investigated the association between BPF and obesity. Experimental studies support the potential obesogenic effects and metabolic disorders mediated by BPS and/or BPF exposure. Sex differences may affect the adverse effects of BPS, but the underlying mechanisms are unclear. Further research is needed to assess the safety and potential effects of BPS and BPF.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Yun Jeong Lee, Youn-Hee Lim, Choong Ho Shin, Bung-Nyun Kim, Johanna Inhyang Kim, Yun-Chul Hong, Yong Min Cho, Young Ah Lee
Summary: This study found a positive association between urinary BPS levels and serum uric acid concentrations in 6-year-old children, with the association being more pronounced in boys. Further investigation into their relationship is warranted given the increasing use of BPS and the concerning impact of hyperuricemia on health outcomes.
Article
Environmental Sciences
Imene Rebai, Jose O. Fernandes, Mohamed Azzouz, Karima Benmohammed, Ghania Bader, Karima Benmbarek, Sara C. Cunha
Summary: BPA and its analogs were found in stable levels in the urine of workers in the plastic industry, with BPA being the main component; the study found significant associations between BPA urinary levels and age, occupational exposure levels, and years of work experience.
ENVIRONMENTAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Yong Guo, Cui Liu, Yu-Hong Deng, Jing Ning, Li Yu, Jie-Ling Wu
Summary: A cross-sectional investigation conducted in Guangzhou, China, reveals that there is a positive correlation between Bisphenol A (BPA) exposure and body composition parameters in children aged 4 to 6 years, providing further evidence for this association.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xinru Huang, Xiaoyi Chen, Shiyu Zhao, Jiaojiao Hou, Li Huang, Jie Xu, Wei Wang, Mengting He, Ouxi Shen, Jie Zhang
Summary: Shift workers were found to be more susceptible to weight gain, central obesity, and impaired lipid metabolism compared to day workers, indicating a higher risk for metabolic health issues associated with disrupted circadian rhythms.
Article
Nutrition & Dietetics
Yolanda Galvez-Ontiveros, Inmaculada Moscoso-Ruiz, Vega Almazan Fernandez de Bobadilla, Celia Monteagudo, Rafael Gimenez-Martinez, Lourdes Rodrigo, Alberto Zafra-Gomez, Ana Rivas
Summary: This study investigated the association between Bisphenol A (BPA) and 11 BPA analogs in children and overweight/obesity. The results suggested that BPF in nails was associated with overweight/obesity in children, while the highest concentrations of BPAF in saliva showed an inverse association. No significant associations were found between exposure to BPA or its analogs and overweight/obesity in other biological matrices.
FRONTIERS IN NUTRITION
(2023)
Article
Environmental Sciences
Jiao Bi, Fei Wang, Yue Wei, Ying Zhang, Chengyong Jia, Jia He, Jinqiu Yao, Zefang Zhang, Zhaoyang Li, Peiwen Li, Meian He
Summary: This study found a positive association between serum bisphenol A (BPA) and incident overweight and obesity risk in a non-monotonic pattern in the Chinese population. Adiponectin may mediate the association.
Article
Food Science & Technology
Iris Reina-Perez, Alicia Olivas-Martinez, Vicente Mustieles, Francisco Javier Ruiz-Ojeda, Jose Manuel Molina-Molina, Nicolas Olea, Mariana F. Fernandez
Summary: BPF and BPS were found to increase intracellular lipid accumulation and affect gene expression related to adipogenesis in human adipose-derived stem cells; their obesogenic effects may involve multiple pathways. This study reveals for the first time the obesogenic potential of BPF in human adipose-derived stem cells.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Xu Hong, Yi Zhou, Zhiyuan Zhu, Yuting Li, Zuo Li, Yuheng Zhang, Xinxin Hu, Fuhai Zhu, Yong Wang, Mingliang Fang, Yichao Huang, Tong Shen
Summary: This study demonstrates a significant association between BPA exposure and risk of obesity, as well as elevated levels of IL-17A in human adipose tissue. Animal experiments further confirm that BPA exposure exacerbates weight gain, insulin resistance, and inflammation in adipose tissue. Genetically modified mice with altered IL-17A gene show reversed inflammatory response and improved insulin sensitivity. Mediation analysis in humans suggests that IL-17A plays a mediating role in the association between BPA exposure and obesity risk.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Minyan Chen, Cheng Lv, Shanyu Zhang, Lap Ah Tse, Xinyu Hong, Xi Liu, Yu Ding, Ping Xiao, Ying Tian, Yu Gao
Summary: This study examined the urine samples of 426 7-year-old children and found a positive association between BPA substitutes BPS and BPAF and obesity, especially in boys. Further research with larger sample size is needed to investigate the obesogenic effects of these chemicals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Environmental
Wenjuan Zhang, Yue Gao, Cheng Chen, Aijing Li, Xuerui Ma, Yong Liang, Xinglei Yao, Maoyong Song, Guibin Jiang
Summary: The study demonstrates that BPS is more likely than BPA to induce visceral fat formation in mice and may cause various metabolic disorders, with succinate potentially playing a key role in inhibiting BPS-induced visceral obesity.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2021)
Article
Public, Environmental & Occupational Health
Giovanna Tranfo, Bruno Papaleo, Lidia Caporossi, Silvia Capanna, Mariangela De Rosa, Daniela Pigini, Federica Corsetti, Enrico Paci
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2013)
Article
Biochemical Research Methods
Lidia Caporossi, Mariangela De Rosa, Bruno Papaleo
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2010)
Article
Public, Environmental & Occupational Health
Bruno Papaleo, Lidia Caporossi, Francesca Bernardini, Luisa Cristadoro, Lucia Bastianini, Mariangela De Rosa, Silvia Capanna, Laura Marcellini, Francesco Loi, Giuseppe Battista
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2011)
Article
Toxicology
Giovanna Tranfo, Lidia Caporossi, Enrico Paci, Cesare Aragona, Daniela Romanzi, Caterina De Carolis, Mariangela De Rosa, Silvia Capanna, Bruno Papaleo, Alessandra Pera
TOXICOLOGY LETTERS
(2012)
Article
Environmental Sciences
Giovanna Tranfo, Lidia Caporossi, Daniela Pigini, Silvia Capanna, Bruno Papaleo, Enrico Paci
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Article
Environmental Sciences
Lidia Caporossi, Alessandra Alteri, Giovanni Campo, Enrico Paci, Giovanna Tranfo, Silvia Capanna, Enrico Papaleo, Daniela Pigini, Paola Vigano, Bruno Papaleo
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Review
Environmental Sciences
Lidia Caporossi, Silvia Capanna, Paola Vigano, Alessandra Alteri, Bruno Papaleo
Summary: Current research on occupational risk factors for endometriosis shows conflicting results, with chemical agents potentially associated with the onset of the disease but requiring further studies for concrete correlation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Diana Poli, Paola Mozzoni, Silvana Pinelli, Delia Cavallo, Bruno Papaleo, Lidia Caporossi
Summary: Sex-related biological differences play a significant role in benzene exposure and its health effects. Animal studies suggest males are more susceptible to adverse effects, while human studies indicate that females have a higher risk for blood system effects and benzene metabolism. Further research is needed to obtain more indicative findings on sex differences related to benzene exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Lidia Caporossi, Paola Vigano, Enrico Paci, Silvia Capanna, Alessandra Alteri, Giovanni Campo, Daniela Pigini, Mariangela De Rosa, Giovanna Tranfo, Bruno Papaleo
Summary: The study revealed significantly higher concentrations of certain phthalates, particularly in women with recurrent pregnancy loss (RPL) and idiopathic infertility. Work environment may have a differential impact on the exposure to these compounds, which warrants further investigation.
Article
Environmental Sciences
Daniela Pigini, Lidia Caporossi, Enrico Paci, Silvia Capanna, Paola Vigano, Alessandra Alteri, Elisa Rabellotti, Flavia Buonaurio, Bruno Papaleo, Giovanna Tranfo
Summary: The study aimed to investigate the correlation between urinary concentrations of phthalates metabolites and biomarkers of nucleic acids oxidation, methylation, or protein nitroxidation. The results showed a positive correlation between phthalate concentrations and oxidative stress biomarkers in both sexes, with higher levels observed in men.
Editorial Material
Environmental Sciences
Lidia Caporossi, Maria Marino
Article
Public, Environmental & Occupational Health
Lidia Caporossi, Bruno Papaleo, Silvia Capanna, Sara Calicchia, Laura Marcellini, Mariangela De Rosa, Paola Castellano
GIORNALE ITALIANO DI MEDICINA DEL LAVORO ED ERGONOMIA
(2015)
Article
Chemistry, Analytical
E. Paci, D. Pigini, L. Caporossi, M. De Rosa, A. Santoro, R. Sisto, B. Papaleo, G. Tranfo
CURRENT ANALYTICAL CHEMISTRY
(2013)
Article
Public, Environmental & Occupational Health
Giovanna Tranfo, Monica Gherardi, E. Paci, Mariapia Gatto, A. Gordiani, Lidia Caporossi, Silvia Capanna, Renata Sisto, B. Papaleo, Carla Fiumalbi, Patrizia Garofani
MEDICINA DEL LAVORO
(2012)