期刊
TOXICOLOGY LETTERS
卷 213, 期 1, 页码 15-20出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2011.11.033
关键词
Endocrine interferent; Phthalates; Biological monitoring; Infertility; Environmental exposure; Case control study
类别
The widespread use of phthalates results in human exposure: phthalates are rapidly metabolized to their respective monoesters and other oxidative products, which are glucuronidated and excreted through the urine and feces. Several in vivo studies showed that some phthalates, in particular diethyl-hexyl phthalate (DEHP), diethyl phthalate (DEP), di(n-butyl)phthalate (DnBP) and n-butylbenzylphthalate (BBzP), are able to interact with the human endocrine system, interfering with the reproduction ability. In this study, 56 couples were recruited from a centre of assisted reproduction. Spot urine samples were collected and five urinary metabolites of the above phthalates were determined using an HPLC/MS/MS analytical method with isotopic dilution. The results were compared with those of 56 couples of parents of one or more children and the statistical analysis revealed a significant difference between the two groups in terms of urinary concentrations of phthalates metabolites. A further step will be the correlation of these results with information on the life styles and working conditions collected through a specifically designed questionnaire. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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