Article
Cell Biology
Tingting Cui, Jiaxin Huang, Yingning Sun, Bolin Ning, Fang Mu, Xin You, Yaqi Guo, Hui Li, Ning Wang
Summary: KLF2 inhibits chicken preadipocyte differentiation at least in part through direct downregulation of PPAR gamma 1 expression. This mechanism involves KLF2 regulation of the P1 promoter of the PPAR gamma gene and effects on histone modifications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qi Zhang, Bohan Cheng, Haixu Jiang, Huili Zhang, Hui Li
Summary: This study found that the ALKBH5 gene is widely expressed in chicken tissues, especially in abdominal adipose tissue. The expression of ALKBH5 is associated with the proliferation and differentiation of chicken preadipocytes.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Agriculture, Multidisciplinary
C. H. E. N. Hong-yan, C. H. E. N. G. Bo-han, M. A. Yan-yan, Z. H. A. N. G. Qi, L. E. N. G. Li, W. A. N. G. Shou-zhi, L. Hui
Summary: Obesity poses a threat to human and broiler health. The study has found that HBP1 inhibits the differentiation of chicken preadipocytes by activating the STAT3 signaling pathway. This discovery provides new insights into the genetic basis of chicken adipose tissue growth and development.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2022)
Article
Agriculture, Dairy & Animal Science
Chiu-Jung Huang, Kong Bung Choo, Chih-Feng Chen
Summary: This review focuses on the effects of signaling transduction on PPARγ in the adipogenesis process and evaluates the role of miRNA in regulating signaling factors and their connection to PPARγ in adipogenesis. Furthermore, the extrapolation of research findings to chicken based on database interrogation and bioinformatics analysis is discussed. Understanding molecular modulation of adipogenesis may have implications for the treatment of lipid disorders and obesity in humans, as well as improving meat quality and commercial value in chicken farming, and possibly in the development of artificial meat.
Article
Agriculture, Dairy & Animal Science
T. Zhang, L. Chen, H. Ding, P. Wu, G. Zhang, Z. Pan, K. Xie, G. Dai, J. Wang
Summary: This study analyzed and identified differentially expressed miRNAs and mRNAs in undifferentiated and differentiated preadipocytes in chicken. A network was constructed with hub miRNAs, providing insight into the regulatory mechanisms of chicken adipogenesis mediated by miRNAs.
BRITISH POULTRY SCIENCE
(2022)
Article
Genetics & Heredity
David Gonzalez-Dieguez, Andres Legarra, Alain Charcosset, Laurence Moreau, Christina Lehermeier, Simon Teyssedre, Zulma G. Vitezica
Summary: This study revisited the theory of hybrid genetic evaluation models in a genomic context and found that GCA accounts for most variation in hybrids, while variances due to dominance and epistasis have similar magnitudes. Different models based on defining effects showed similar predictive abilities for hybrids.
Article
Genetics & Heredity
Raissa Cristina Dias Graciano, Rafael Sachetto Oliveira, Isllas Miguel Santos, Gabriel M. Yazbeck
Summary: The Neotropical region is known for its diverse freshwater fish fauna and is facing significant conservation challenges. This study focuses on Salminus brasiliensis, a potential flagship Neotropical species with pressing conservation issues. The researchers provide comprehensive genomic resources for this species, including genomic sequences, de novo assembly, gene annotation, and microsatellite loci for DNA marker development. These resources will facilitate general biology studies and contribute to conservation and aquaculture efforts for this candidate flagship species.
FRONTIERS IN GENETICS
(2022)
Article
Ophthalmology
Zhiwei Ma, Daniel Chauss, Joshua Disatham, Xiaodong Jiao, Lisa Ann Brennan, A. Sue Menko, Marc Kantorow, J. Fielding Hejtmancik
Summary: This study identified the expression patterns of crystallin genes during the transition from lens epithelial cells to lens fiber cells in embryonic day 13 chicken lenses. Three distinct expression patterns of crystallin genes were discovered, each highly correlated with specific transcription factors. These findings provide quantitative evidence for understanding the mechanisms that govern crystallin expression during fiber cell differentiation for achieving lens transparency.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Genetics & Heredity
Juan Antonio Baeza, Mei Lin Neo, Danwei Huang
Summary: In this study, the researchers estimated the genome size and unique genome content of the giant clam Tridacna crocea using low-pass short read sequencing. They also attempted to assemble the mitochondrial genome from RNA sequencing data. Additionally, they partially assembled the nuclear ribosomal operon and identified common repetitive elements in the genome of T. crocea. These genomic resources are important for understanding the biology and conservation of this reef-dwelling invertebrate.
Article
Biotechnology & Applied Microbiology
Katharina Sielemann, Boas Pucker, Elena Orsini, Abdelnaser Elashry, Lukas Schulte, Prisca Viehoever, Andreas E. Mueller, Axel Schechert, Bernd Weisshaar, Daniela Holtgraewe
Summary: In this study, we identified the causal genes providing tolerance against BCN infection in sugar beet by combining experimental and bioinformatic approaches. Our findings contribute to the understanding of plant-nematode interactions and can be used to develop new management strategies against BCN.
Article
Microbiology
Khaloud O. Alzahrani, Fahad M. AL-Reshoodi, Elaf A. Alshdokhi, Ashwaq S. Alhamed, Meshari A. Al Hadlaq, Mohammed I. Mujallad, Lenah E. Mukhtar, Amani T. Alsufyani, Abdullah A. Alajlan, Malfi S. Al Rashidy, Mashan J. Al Dawsari, Saleh I. Al-Akeel, Meshari H. AL-Harthi, Abdulaziz M. Al Manee, Majed F. Alghoribi, Suliman M. Alajel
Summary: This study utilized whole genome sequencing (WGS) technology to investigate the genotypic and phenotypic antimicrobial resistance profiles, phylogenic relatedness, plasmid and virulence composition of Salmonella enterica strains isolated from chicken meat samples. The results revealed four distinct serotypes and identified the distribution of resistance genes and plasmids among the strains. The presence of Salmonella pathogenicity islands and stress/virulence genes was also observed. This study provides important insights into the genomic characterization of Salmonella isolates from retail chicken meat and highlights the potential usefulness of WGS technology in epidemiological surveillance and outbreak investigations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Mohammad Khoveyni, Robabeh Eslami
Summary: This study proposes an input-output-oriented linear model in network data envelopment analysis (DEA) to measure the overall efficiency of two-stage decision-making units (DMUs) with shared resources. Comparative analysis shows the superiority of our model over existing models, and an empirical example demonstrates the applicability of our proposed model.
KNOWLEDGE-BASED SYSTEMS
(2022)
Article
Biochemistry & Molecular Biology
Huaixi Luo, Hao Zhou, Shengyao Jiang, Chuan He, Ke Xu, Jinmei Ding, Jiajia Liu, Chao Qin, Kangchun Chen, Wenchuan Zhou, Liyuan Wang, Wenhao Yang, Wenqi Zhu, He Meng
Summary: This study identified potential key genes and speculated about the mechanisms associated with ovary and testis development in chicken embryos. The analysis of transcriptome sequencing data revealed asymmetrical expression of gonads and identified differentially expressed genes on the left side.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Evolutionary Biology
Zhou Wu, Chiara Bortoluzzi, Martijn F. L. Derks, Langqing Liu, Mirte Bosse, Sipke Joost Hiemstra, Martien A. M. Groenen, Richard P. M. A. Crooijmans
Summary: This study demonstrates the heterogeneity of the bantam trait in Dutch chickens and reveals the underlying genetic causes. Multiple genetic variants and genes associated with the bantam phenotype were identified through genome-wide association studies, including HMGA2 and PRDM16, genes involved in body growth and stature.
EVOLUTIONARY APPLICATIONS
(2021)
Article
Genetics & Heredity
Marnin D. Wolfe, Ariel W. Chan, Peter Kulakow, Ismail Rabbi, Jean-Luc Jannink
Summary: The study introduced genomic mate selection criteria suitable for organisms of arbitrary homozygosity level, successfully predicting the genetic distribution of cassava families. Breeders can now use predictions to select future parents and develop varieties.