Modulation of Microglial Activity by Rho-Kinase (ROCK) Inhibition as Therapeutic Strategy in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

Rho kinase inhibitors: a patent review (2014 – 2016)

(2017) Olivier Defert et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Rho Kinase Inhibition with Fasudil in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis—Symptomatic Treatment Potential after Disease Onset

(2017) René Günther et al.   Frontiers in Pharmacology

Altered Expression of Growth Associated Protein-43 and Rho Kinase in Human Patients with Parkinson's Disease

(2016) Kim-Ann Saal et al.   BRAIN PATHOLOGY

Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis

(2016) Mohamad J. Alshikho et al.   NEUROLOGY

Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease

(2016) Xiao-Yan Qin et al.   JAMA Neurology

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease

(2016) Lars Tatenhorst et al.   Acta Neuropathologica Communications

Inhibition of Rho-kinase by Fasudil protects dopamine neurons and attenuates inflammatory response in an intranasal lipopolysaccharide-mediated Parkinson's model

(2015) Qing He et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

(2015) Yangbo Feng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multitarget intervention of Fasudil in the neuroprotection of dopaminergic neurons in MPTP-mouse model of Parkinson's disease

(2015) Yong-fei Zhao et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo

(2015) Kim-Ann Saal et al.   NEUROBIOLOGY OF DISEASE

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders

(2015) Niko Hensel et al.   Frontiers in Neuroscience

Imaging Striatal Microglial Activation in Patients with Parkinson’s Disease

(2015) Yuko Koshimori et al.   PLoS One

Ripasudil: First Global Approval

(2014) Karly P. Garnock-Jones   DRUGS

Glial cells in amyotrophic lateral sclerosis

(2014) T. Philips et al.   EXPERIMENTAL NEUROLOGY

RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain

(2014) Emiko Tatsumi et al.   GLIA

Interaction between NADPH-oxidase and Rho-kinase in angiotensin II-induced microglial activation

(2014) Ana I. Rodriguez-Perez et al.   GLIA

Rho Kinase Inhibition by Fasudil in the Striatal 6-Hydroxydopamine Lesion Mouse Model of Parkinson Disease

(2014) Lars Tatenhorst et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Inhibition of the microglial response is essential for the neuroprotective effects of Rho-kinase inhibitors on MPTP-induced dopaminergic cell death

(2014) Ana Borrajo et al.   NEUROPHARMACOLOGY

Rho Kinase and Dopaminergic Degeneration

(2014) Jose L. Labandeira-Garcia et al.   NEUROSCIENTIST

Reduced Inflammatory Phenotype in Microglia Derived from Neonatal Rat Spinal Cord versus Brain

(2014) Sam Joshva Baskar Jesudasan et al.   PLoS One

The rho kinase inhibitor Y-27632 improves motor performance in male SOD1G93A mice

(2014) René Günther et al.   Frontiers in Neuroscience

Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients

(2013) Antonio Conti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis

(2013) M Takata et al.   BRITISH JOURNAL OF PHARMACOLOGY

Double-Blind, Placebo-Controlled Clinical Trial With a Rho-Kinase Inhibitor in Pulmonary Arterial Hypertension

(2013) Yoshihiro Fukumoto et al.   CIRCULATION JOURNAL

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis

(2013) Lars Tönges et al.   GLIA

Microglial TNF-α mediates enhancement of dopaminergic degeneration by brain angiotensin

(2013) Ana Borrajo et al.   GLIA

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

(2013) Carmen Noelker et al.   Scientific Reports

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

(2012) L. Tonges et al.   BRAIN

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

(2012) Jenny S. Henkel et al.   EMBO Molecular Medicine

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

(2012) Bing Liao et al.   EXPERIMENTAL NEUROLOGY

Inflammation and neurovascular changes in amyotrophic lateral sclerosis

(2012) M.C. Evans et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Involvement of microglial RhoA/Rho-Kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors

(2012) Begoña Villar-Cheda et al.   NEUROBIOLOGY OF DISEASE

Early Functional Deficit and Microglial Disturbances in a Mouse Model of Amyotrophic Lateral Sclerosis

(2012) Yannick Nicolas Gerber et al.   PLoS One

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

(2012) Carlos Barcia et al.   Scientific Reports

Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro

(2011) Jun Yan et al.   JOURNAL OF NEUROCHEMISTRY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

In Vivo Imaging Reveals Distinct Inflammatory Activity of CNS Microglia versus PNS Macrophages in a Mouse Model for ALS

(2011) Payam Dibaj et al.   PLoS One

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice

(2010) Jing Ding et al.   JOURNAL OF NEUROCHEMISTRY

Nitrated Alpha-Synuclein and Microglial Neuroregulatory Activities

(2008) Ashley D. Reynolds et al.   Journal of Neuroimmune Pharmacology

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY