标题
Apigenin in cancer therapy: anti-cancer effects and mechanisms of action
作者
关键词
Apigenin, Anti-cancer, Mechanism of action, Combination therapy
出版物
Cell and Bioscience
Volume 7, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-10-05
DOI
10.1186/s13578-017-0179-x
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Synergistic Effect of Graphene Oxide Coated Nanotised Apigenin with Paclitaxel (GO-NA/PTX): A ROS Dependent Mitochondrial Mediated Apoptosis in Ovarian Cancer
- (2018) Manish Kumar Pal et al. Anti-Cancer Agents in Medicinal Chemistry
- Study on the Pulmonary Delivery System of Apigenin-Loaded Albumin Nanocarriers with Antioxidant Activity
- (2017) Zsófia Edit Pápay et al. Journal of Aerosol Medicine and Pulmonary Drug Delivery
- Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy
- (2017) Pablo Angulo et al. Journal of Hematology & Oncology
- Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells
- (2017) Guangming Zhao et al. ONCOLOGY REPORTS
- Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice
- (2017) Samar M. Hassan et al. PHARMACEUTICAL BIOLOGY
- Maximising the potential of AKT inhibitors as anti-cancer treatments
- (2017) Jessica S. Brown et al. PHARMACOLOGY & THERAPEUTICS
- A systems biology approach to overcome TRAIL resistance in cancer treatment
- (2017) Kumar Selvarajoo PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms
- (2017) Hanaa H. Gaballah et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway
- (2017) Yi Wan et al. TUMOR BIOLOGY
- In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma
- (2017) Laura Masuelli et al. Frontiers in Pharmacology
- Wnt signaling in triple-negative breast cancer
- (2017) SÖ-G Pohl et al. Oncogenesis
- Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer
- (2017) Nadine Nelson et al. PLoS One
- Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
- (2017) Chung-Ming Lin et al. Scientific Reports
- Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells
- (2016) Melanie R. Power Coombs et al. CANCER LETTERS
- Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention
- (2016) Bryan B. Bridgeman et al. CELLULAR SIGNALLING
- Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
- (2016) Jason S. L. Yu et al. DEVELOPMENT
- Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1expression
- (2016) Tsui-Hwa Tseng et al. ENVIRONMENTAL TOXICOLOGY
- Chrysin, Abundant in Morinda citrifolia Fruit Water–EtOAc Extracts, Combined with Apigenin Synergistically Induced Apoptosis and Inhibited Migration in Human Breast and Liver Cancer Cells
- (2016) Cheng Huang et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Apigenin Reduces Survival of Choriocarcinoma Cells by Inducing Apoptosis via the PI3K/AKT and ERK1/2 MAPK Pathways
- (2016) Whasun Lim et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The flavonoid apigenin reduces prostate cancer CD44 + stem cell survival and migration through PI3K/Akt/NF-κB signaling
- (2016) Suat Erdogan et al. LIFE SCIENCES
- Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling
- (2016) Boram Kim et al. PHYTOTHERAPY RESEARCH
- Heteronemin Is a Novel c-Met/STAT3 Inhibitor Against Advanced Prostate Cancer Cells
- (2016) Jian-Ching Wu et al. PROSTATE
- Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells
- (2016) Jin Dai et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Fulvestrant inhibits growth of triple negative breast cancer and synergizes with tamoxifen in ERα positive breast cancer by up-regulation of ERβ
- (2016) Ameet K. Mishra et al. Oncotarget
- Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma
- (2016) Hui-Hui Cao et al. Scientific Reports
- Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner
- (2016) Minghui Chen et al. Scientific Reports
- Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells
- (2015) H.-S. Seo et al. BIOSCIENCE REPORTS
- Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway
- (2015) Chia-Hung Lin et al. BMC CANCER
- Wnt/β-catenin signaling in bone marrow niche
- (2015) Ahmad Ahmadzadeh et al. CELL AND TISSUE RESEARCH
- 5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma
- (2015) Xiao-Yun Hu et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Bcl-2 family of proteins as drug targets for cancer chemotherapy: the long way of BH3 mimetics from bench to bedside
- (2015) Laura Vela et al. CURRENT OPINION IN PHARMACOLOGY
- The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer
- (2015) Yoon Yang Jung et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Discoveries and controversies in BCL-2 protein-mediated apoptosis
- (2015) Janet H. Zheng et al. FEBS Journal
- Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis
- (2015) Qun Wang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress
- (2015) YOON-MI LEE et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1
- (2015) JIN FANG et al. Molecular Medicine Reports
- Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells
- (2015) HYE-SOOK SEO et al. Molecular Medicine Reports
- Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition
- (2015) Md. Hasnat et al. MOLECULES
- Combination cancer immunotherapy and new immunomodulatory targets
- (2015) Kathleen M. Mahoney et al. NATURE REVIEWS DRUG DISCOVERY
- Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway
- (2015) XIAOFENG LIU et al. ONCOLOGY REPORTS
- Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo
- (2015) YANG-YANG BAO et al. ONCOLOGY REPORTS
- Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells
- (2015) Li Zhang et al. Food & Function
- Apigenin blocks IKKα activation and suppresses prostate cancer progression
- (2015) Sanjeev Shukla et al. Oncotarget
- Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells
- (2015) Pei-Shan Wu et al. PLoS One
- Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice
- (2015) Sanjeev Shukla et al. PLoS One
- Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70–Bax interaction in prostate cancer
- (2014) Sanjeev Shukla et al. APOPTOSIS
- The MAPK pathway across different malignancies: A new perspective
- (2014) Mauricio Burotto et al. CANCER
- Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion
- (2014) Shumin Ding et al. International Journal of Nanomedicine
- Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells
- (2014) YUJIN LEE et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells
- (2014) YOUNG-AH SUH et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer
- (2014) YI ZHU et al. Molecular Medicine Reports
- Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2α
- (2014) JIE LIU et al. Molecular Medicine Reports
- Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3-derived sphere-forming cells
- (2014) AI-QIONG TANG et al. Molecular Medicine Reports
- Therapeutic Potential of Apigenin, a Plant Flavonoid, for Imatinib-Sensitive and Resistant Chronic Myeloid Leukemia Cells
- (2014) Soner Solmaz et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer
- (2014) Athanasia Pavlidou et al. TheScientificWorldJOURNAL
- Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention
- (2013) Xin Tong et al. Anti-Cancer Agents in Medicinal Chemistry
- Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
- (2013) J. Duraiswamy et al. CANCER RESEARCH
- Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway
- (2013) S. Shukla et al. CARCINOGENESIS
- Wnt signaling in adult intestinal stem cells and cancer
- (2013) Michaela Krausova et al. CELLULAR SIGNALLING
- miR-138 overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo
- (2013) Mrinmay Chakrabarti et al. EXPERIMENTAL CELL RESEARCH
- Interactions between dietary flavonoids apigenin or luteolin and chemotherapeutic drugs to potentiate anti-proliferative effect on human pancreatic cancer cells, in vitro
- (2013) Jodee L. Johnson et al. FOOD AND CHEMICAL TOXICOLOGY
- Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis
- (2013) DANIELE MAGGIONI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT
- (2013) Li Chunhua et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Apigenin Sensitizes Colon Cancer Cells to Antitumor Activity of ABT-263
- (2013) H. Shao et al. MOLECULAR CANCER THERAPEUTICS
- Apigenin Sensitizes Prostate Cancer Cells to Apo2L/TRAIL by Targeting Adenine Nucleotide Translocase-2
- (2013) Masakatsu Oishi et al. PLoS One
- Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets
- (2013) D. Arango et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer
- (2012) Wiem Chaabane et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- Beclin1: A role in membrane dynamics and beyond
- (2012) Ellen Wirawan et al. Autophagy
- Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL
- (2012) Hui Tian et al. CANCER LETTERS
- In vitro anti-inflammatory effect of apigenin in the Helicobacter pylori-infected gastric adenocarcinoma cells
- (2012) Yuan-Chuen Wang et al. FOOD AND CHEMICAL TOXICOLOGY
- Biopharmaceutics classification and intestinal absorption study of apigenin
- (2012) Jianjun Zhang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Design of novel BH3 mimetics for the treatment of chronic lymphocytic leukemia
- (2012) C Billard LEUKEMIA
- Apigenin Inhibits NNK-Induced Focal Adhesion Kinase Activation in Pancreatic Cancer Cells
- (2012) Hung Pham et al. PANCREAS
- Acute Exposure of Apigenin Induces Hepatotoxicity in Swiss Mice
- (2012) Prabhat Singh et al. PLoS One
- How do they do Wnt they do?: regulation of transcription by the Wnt/β-catenin pathway
- (2011) H. C. Archbold et al. Acta Physiologica
- Regulation of autophagy by lysosomal positioning
- (2011) Viktor I. Korolchuk et al. Autophagy
- Apigenin Induces Apoptosis in Human Leukemia Cells and Exhibits Anti-Leukemic Activity In Vivo
- (2011) A. Budhraja et al. MOLECULAR CANCER THERAPEUTICS
- Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes
- (2011) Xin Tong et al. MOLECULAR CARCINOGENESIS
- Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids
- (2011) Berrin Özçelik et al. PHARMACEUTICAL BIOLOGY
- Apigenin Attenuates Insulin-Like Growth Factor-I Signaling in an Autochthonous Mouse Prostate Cancer Model
- (2011) Sanjeev Shukla et al. PHARMACEUTICAL RESEARCH
- Immunotherapy for Melanoma: Current Status and Perspectives
- (2010) Doru T. Alexandrescu et al. JOURNAL OF IMMUNOTHERAPY
- Flavonoids inhibit angiogenic cytokine production by human glioma cells
- (2010) Sandra Freitas et al. PHYTOTHERAPY RESEARCH
- Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy
- (2010) R R Ruela-de-Sousa et al. Cell Death & Disease
- A New Fork for Clinical Application: Targeting Forkhead Transcription Factors in Cancer
- (2009) J.-Y. Yang et al. CLINICAL CANCER RESEARCH
- Enhancement of UVB-Induced Apoptosis by Apigenin in Human Keratinocytes and Organotypic Keratinocyte Cultures
- (2008) A. O. Abu-Yousif et al. CANCER RESEARCH
- Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase
- (2008) X.-W. Hu et al. CARCINOGENESIS
- Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises
- (2008) Timothy A Yap et al. CURRENT OPINION IN PHARMACOLOGY
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