Review
Pharmacology & Pharmacy
Jincai Chen, Xiaofei Liao, Juwen Gan
Summary: Osteoporosis is a disease characterized by continuous bone loss and increased fracture risk. Osthole, a natural compound derived from certain plants, shows promise in protecting against the development of osteoporosis and could potentially be developed into a treatment agent.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Meng Chen, Liying Shan, Ying Gan, Lijie Tian, Jie Zhou, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: MTSS1 plays a role in osteoblast differentiation and bone homeostasis by regulating Src-Wnt/beta-catenin signaling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yunok Oh, Chang-Bum Ahn, M. P. C. K. Marasinghe, Jae-Young Je
Summary: Chitosan, a naturally occurring biodegradable polymer, demonstrates osteogenic effects in murine bone marrow-derived mesenchymal stem cells. Grating gallic acid onto chitosan enhances its potential for osteogenesis. Mechanistic study shows that GAC activates the Wnt signaling pathway to promote osteoblast differentiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell & Tissue Engineering
Xiaowen Wu, Xiaochen Wang, Liying Shan, Jie Zhou, Xin Zhang, Endong Zhu, Hairui Yuan, Baoli Wang
Summary: The loss of NFIX gene affects endochondral ossification and mineralization in bone, with NFIX inducing osteoblast differentiation and impairing adipocyte formation by regulating HMGA1 expression. HMGA1 plays a role in osteoblast commitment and mediates NFIX function by activating canonical Wnt signaling pathways.
Article
Genetics & Heredity
Zixue Jiao, Hao Chai, Shendong Wang, Chunguang Sun, Qun Huang, Wei Xu
Summary: It has been found that inhibiting SOST gene can trigger the osteocyte Wnt/β-catenin signaling cascade, inhibit osteoporosis, and reduce periprosthetic osteolysis. The study results show that inhibiting SOST can significantly improve bone density and volume, reduce the number of osteolysis pores, and decrease the extent of skull erosion. In addition, inhibiting SOST can reverse the effects of titanium particles on bone cells, preventing particle-induced bone resorption and destruction.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Integrative & Complementary Medicine
Yi Shen, Na Wang, Qi Zhang, Yuling Liu, Qudi Wu, Yuqiong He, Yang Wang, Xiaoyan Wang, Qiming Zhao, Quanlong Zhang, Luping Qin, Qiaoyan Zhang
Summary: Jin-Tian-Ge (JTG), an artificial tiger bone powder, has bone-protective effects by promoting osteogenic differentiation of BMSCs through the regulation of BMP and Wnt/beta-catenin pathways, and inhibiting osteoclastogenesis by suppressing the NF-kappa B pathway. This study suggests that JTG has potential for prevention and treatment of osteoporosis.
Article
Biochemistry & Molecular Biology
Ashish Kumar Tripathi, Divya Rai, Priyanka Kothari, Pragati Kushwaha, Koneni Sashidhara, Ritu Trivedi
Summary: A compound, 4e, has been identified to have osteogenic potential in glucocorticoid induced osteoporosis (GIOP). Compound 4e preserved osteoblast differentiation and increased the expression of osteogenic genes, resulting in the preservation of bone microarchitecture and cortical thickness. This study is important for the treatment of glucocorticoid-induced osteoporosis.
Review
Biochemistry & Molecular Biology
Tommy W. Sutor, Jayachandra Kura, Alex J. Mattingly, Dana M. Otzel, Joshua F. Yarrow
Summary: Spinal cord injury causes paralysis and osteoporosis, increasing fracture risk. Physical rehabilitation regimens for patients with severe SCI have limited evidence in influencing bone metabolism or increasing bone mineral density.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Leyao Shen, Deepika Sharma, Yilin Yu, Fanxin Long, Courtney M. Karner
Summary: Osteoblasts have increased demand for amino acids to support bone matrix synthesis, with WNT signaling rapidly inducing glutamine uptake through specific amino acid transporters. This process is critical for osteoblast differentiation.
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Hairui Yuan, Mengyue Li, Xue Feng, Endong Zhu, Baoli Wang
Summary: miR-142a-5p plays a critical role in osteoblast differentiation by targeting NFIA and being regulated by the Wnt/beta-catenin signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Zheni Stavre, Jung-Min Kim, Yeon-Suk Yang, Kerstin Nundel, Sachin Chaugule, Tadatoshi Sato, Kwang Hwan Park, Guangping Gao, Ellen M. Gravallese, Jae-Hyuck Shim
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes systemic and articular bone loss. Suppressing the expression of Schnurri-3 (SHN3) can protect against inflammation-induced bone loss in RA models. Inhibition of SHN3 shows promise in limiting bone loss and promoting bone repair in RA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Gastroenterology & Hepatology
Hongting Huang, Liang Wu, Li Lu, Zijie Zhang, Bijun Qiu, Jialin Mo, Yi Luo, Zhifeng Xi, Mingxuan Feng, Ping Wan, Jianjun Zhu, Dingye Yu, Wei Wu, Kezhe Tan, Jiangbin Liu, Qingfeng Sheng, Ting Xu, Jinyan Huang, Zhibao Lv, Yujie Tang, Qiang Xia
Summary: This study illustrates the cellular architecture and developmental trajectories of hepatoblastoma (HB) through integrative bulk and single-cell transcriptome analyses, establishing a resourceful framework for the development of targeted diagnostics and therapeutics in the future.
Review
Medicine, General & Internal
Martina Rauner, Hanna Taipaleenmaeki, Elena Tsourdi, Elizabeth M. Winter
Summary: Osteoporosis is a common disease characterized by reduced bone mass, and Romosozumab, as a novel monoclonal antibody against sclerostin, has a dual mode of action that enhances bone formation and suppresses bone resorption simultaneously, offering potential as a new effective treatment for patients at high fracture risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Emily Ling-Lin Pai, April M. Stafford, Daniel Vogt
Summary: The development and maturation of cortical GABAergic interneurons involve both transcriptional regulation via nuclear factors and cellular signaling cascades including mTOR, MAPK, and Wnt/beta-catenin pathways. These signaling families play important roles in regulating various developmental milestones and properties of interneurons. The coordination between transcriptional and signaling mechanisms is crucial for the complex diversity observed during cortical interneuron development and maturation.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Cell Biology
Rachel S. S. Perkins, Sarocha Suthon, Gustavo A. A. Miranda-Carboni, Susan A. A. Krum
Summary: In this article, the researchers review the current understanding of the regulation of WNT5B signal transduction and its roles in different types of Wnt signaling pathways.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Narges Ansari, Sahar Najafi, Saied Shahrabi, Najmaldin Saki
Summary: PEAR1, a platelet receptor, is crucial for hemostasis by mediating platelet adhesion and aggregation. Dysfunctional PEAR1 can disrupt platelet aggregation in CVDs patients. Studies suggest that PEAR1 polymorphisms could affect homeostasis and the function of cardiac drugs, indicating potential implications for patient treatment.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Review
Oncology
Hassan Rafieemehr, Masumeh Maleki Behzad, Saeed Azandeh, Niloofar Farshchi, Mohammad Ghasemi Dehcheshmeh, Najmaldin Saki
Summary: The BM niche is a specific microenvironment for HSCs and non-hematopoietic cells, and evidence suggests that chemo/radiotherapy can disrupt the balance within the marrow cavity, leading to bone loss, abnormal hematopoiesis, and enhanced differentiation potential of mesenchymal stem cells towards adipogenesis. Understanding the mechanisms behind these changes may help in the development of therapeutic interventions to prevent BM niche defects.
CANCER INVESTIGATION
(2021)
Review
Cell Biology
Sahar Najafi, Majid Ghanavat, Saied Shahrabi, Zahra Gatavizadeh, Najmaldin Saki
Summary: Inflammatory cytokines play a critical role in the differentiation of HSCs, stimulating or inhibiting hematopoietic progenitors to combat inflammation and leukemic conditions.
CELL BIOLOGY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Habib Hybar, Najmaldin Saki, Mohsen Maleknia, Mana Moghaddasi, Armin Bordbar, Maliheh Naghavi
Summary: AERD is characterized by immune cells dysfunction, with ILC-2 playing a significant role in disease progression by producing cytokines that induce allergic reactions and activate mast cells and basophils, ultimately exacerbating the condition. Monoclonal antibody therapy and Aspirin desensitization have been identified as potential treatment strategies for prevention and management.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Cell Biology
Mohammad R. Javan, Najmaldin Saki, Bahareh Moghimian-Boroujeni
Summary: Aplastic anemia is an autoimmune disorder characterized by bone marrow and peripheral blood pancytopenia, with the pathogenesis remaining unclear. The disease involves impairment of both hematopoietic stem cells and mesenchymal stromal cells, leading to changes in T lymphocyte ratio and disease progression. The most common mechanism of AA is damage by the immune system, causing increased apoptosis in progenitor cells.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Microbiology
Elham Aboualigalehdari, Maryam Tahmasebi Birgani, Mahnaz Fatahinia, Mehran Hosseinzadeh
Summary: The study found that BCR1, CAT1, and EFG1 genes were significantly higher expressed in persister isolates of Candida albicans producing biofilms compared to non-persister isolates. The most crucial factor in the production of persister cells was identified to be biofilm binding and production, rather than biofilm development. Catalase also played an essential role in the production of persister cells in C. albicans biofilm producers by detoxifying ROS.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Oncology
Mahdiyar Iravani Saadi, Mani Ramzi, Mehran Hosseinzadeh, Narjes Ebrahimi, Maryam Owjfard, Ehsan Nabi Abdolyousefi, Zahra Hesami, Behnaz Valibeigi, Neda Zareei, Fataneh Tavasolian, Hourvash Haghighinejad, Abdolhossein Zare
Summary: This study evaluated the expression levels of IL-6 and IL-18 in AML patients and found that the expression levels of these cytokines were associated with treatment response and GvHD. Higher levels of IL-6 and IL-18 were observed in patients without response to treatment or experiencing aGvHD after bone marrow transplantation.
INDIAN JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Mathematical & Computational Biology
Mina Jahangiri, Fakher Rahim, Najmaldin Saki, Amal Saki Malehi
Summary: This study introduces a Bayesian tree-based method for differentiating between beta-thalassemia trait and iron deficiency anemia. The models propose automatic detection of beta-thalassemia carriers, with mean corpuscular volume being the main predictor in diagnostic discrimination. CART showed higher sensitivity and negative predictive value compared to BLTREED, but with a higher false-positive rate. The BLTREED model demonstrated better performance in terms of area under the curve.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2021)
Review
Oncology
Daryush Purrahman, Arshid Yousefi Avarvand, Agnieszka Paradowska-Gorycka, Najmaldin Saki, Hossein Karimpourian, Hossein Jodat, Mohammad-Reza Mahmoudian-Sani
Summary: Breast cancer is a common cancer among women, and its exact cause is still unknown. The association between human papillomavirus (HPV) and breast cancer has been explored in numerous studies, but contradictory results have been obtained. This review examines the existing evidence and hypotheses about the association between HPV infection and breast cancer, as well as the potential mechanisms involved.
Article
Pharmacology & Pharmacy
Reza Safaei Nodehi, Behjat Kalantari, Jahangir Raafat, Nafiseh Ansarinejad, Vahid Moazed, Seyed Mohammad Reza Mortazavizadeh, Mehran Hosseinzadeh, Bayazid Ghaderi, Arash Jenabian, Mojtaba Qadyani, Shirin Haghighat, Abolghasem Allahyari, Mehrzad Mirzania, Mohammad Seghatoleslami, Mehrdad Payandeh, Afsaneh Alikhasi, Hamidreza Kafi, Farhad Shahi
Summary: This study compared the efficacy and safety of TA4415V, a trastuzumab biosimilar, with reference trastuzumab in Iranian patients with early-stage breast cancer. The results showed no significant difference in pathologic complete response rate, overall response rate, and breast-conserving surgery rate between TA4415V and reference trastuzumab. The safety profile and immunogenicity were also comparable.
BMC PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Oncology
Abolghasem Allahyari, Ali Ehsanpour, Nafiseh Ansarinejad, Valiollah Mehrzad, Behjat Kalantari, Jahangir Raafat, Mojtaba Ghadiany, Farhad Shahi, Behrooz Gharib, Vahid Moazed, Adnan Khosravi, Mir Hossein Mirpour, Sina Salari, Seyedmohammadreza Mortazavizadeh, Amirabbas Nekoyi, Mohsen Khani, Alireza Sadeghi, Sirus Gharib, Alireza Bary, Mehrzad Mirzania, Shirin Haghighat, Seyed Mohsen Razavi, Seyed Amir Hossein Emami, Mehran Hosseinzadeh, Mahdi Mirbolouk, Sanambar Sadighi, Abdolali Shahrasbi, Ali Esfahani, Masoumeh Gity, Nassim Anjidani, Hamidreza Kafi, Safa Najafi
Summary: This study compared the efficacy and safety of a proposed pertuzumab biosimilar with the reference pertuzumab in HER2-positive breast cancer patients. The results showed that the proposed biosimilar was equivalent in efficacy and safety to the reference product, which is clinically significant for the treatment of breast cancer patients.
Review
Virology
Alireza Mohebbi, Habib Haybar, Fatemeh Nakhaei Moghaddam, Zahra Rasti, Mohammad Amin Vahid, Najmaldin Saki
Summary: This study found that COVID-19 patients had endothelial dysfunction and elevated levels of endothelial biomarkers. Patients with poor outcome had higher levels of von Willebrand factor, Ang-2, E-selectin, P-selectin, syndecan-1, MR-proADM, vascular endothelial growth factor, sFLT-1, and lower levels of ADAMTS13 compared to patients with good outcome.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Pediatrics
Fatemeh Zeylabi, Mohammad Taha Jalali, Gholam-Abbas Kaydani, Kaveh Jaseb, Najmaldin Saki
Summary: Immune thrombocytopenic purpura (ITP) is an immune bleeding disorder associated with genetic factors and interleukin-10 (IL-10) rs1800890 polymorphism. This study found that individuals with the AA genotype were less likely to develop ITP, while the AT genotype was more common in ITP patients. However, there was no significant association between rs1800890 genotypes in the acute and chronic groups. Additionally, women had a higher frequency of this polymorphism and the rs1800890 AA genotype was associated with higher platelet counts.
JOURNAL OF PEDIATRIC GENETICS
(2023)
Review
Genetics & Heredity
Habib Haybar, Narjes Sadat Sadati, Daryush Purrahman, Mohammad Reza Mahmoudian-Sani, Najmaldin Saki
Summary: Cardiovascular diseases (CVDs) are major causes of death worldwide. Understanding the molecular mechanisms and signaling pathways involved in CVD pathogenesis is crucial for the development of accurate diagnostic techniques, effective prognostic markers, and potential therapeutic targets. Recent research suggests that the lncRNA TUG1 can serve as a biomarker for predicting the prognosis of CVD.
