Review
Nutrition & Dietetics
Maribel Luceron-Lucas-Torres, Ivan Cavero-Redondo, Vicente Martinez-Vizcaino, Alicia Saz-Lara, Carlos Pascual-Morena, Celia Alvarez-Bueno
Summary: This study suggests a potential protective effect of wine consumption against cognitive decline, although further research is needed to differentiate between types of wine.
FRONTIERS IN NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Yi-Cheng Lin, Chih-Ping Chung, Pei-Lin Lee, Kun-Hsien Chou, Li-Hung Chang, Szu-Ying Lin, Yi-Jung Lee, Ching-Po Lin, Pei-Ning Wang
Summary: The coexistence of physical and cognitive impairments in older adults can predict incident disability, dementia, and mortality. This study investigated the natural course and prevalence of these impairments and found that skeletal muscle mass/function and memory function are crucial factors associated with the progression or reversal of functional impairments.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Dora Csengeri, Ngoc-Anh Sprunker, Augusto Di Castelnuovo, Teemu Niiranen, Julie Kk Vishram-Nielsen, Simona Costanzo, Stefan Soderberg, Steen M. Jensen, Erkki Vartiainen, Maria Benedetta Donati, Christina Magnussen, Stephan Camen, Francesco Gianfagna, Maja-Lisa Lochen, Frank Kee, Jukka Kontto, Ellisiv B. Mathiesen, Wolfgang Koenig, Blankenberg Stefan, Giovanni de Gaetano, Torben Jorgensen, Kari Kuulasmaa, Tanja Zeller, Veikko Salomaa, Licia Iacoviello, Renate B. Schnabel
Summary: This study found that even modest alcohol intake (1.2 drinks/day) was associated with an increased risk of atrial fibrillation, which needs to be considered in atrial fibrillation prevention.
EUROPEAN HEART JOURNAL
(2021)
Article
Endocrinology & Metabolism
Ji Hee Yu, Regina E. Y. Kim, So Young Park, Da Young Lee, Hyun Joo Cho, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Chol Shin, Nan Hee Kim
Summary: This study investigated the longitudinal changes in brain volume and cognitive function associated with diabetes at midlife, and found that type 2 diabetes is associated with greater white matter volume reduction and executive function decline. Long-term hyperglycemia was identified as a major independent factor associated with rapid cognitive decline in middle-aged adults with diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Clinical Neurology
Larissa Salvador, Luana Giatti, Maria Carmen Viana, Claudia Kimie Suemoto, Bruce B. Duncan, Maria del Carmen Bisi Molina, Maria de Jesus Mendes da Fonseca, Andre R. Brunoni, Sandhi Maria Barreto, Paulo Caramelli
Summary: This study aimed to investigate the impact of alcohol intake on cognition in middle-aged participants and found that heavy alcohol consumption can affect executive functions in men and memory in women, while moderate alcohol intake may have a protective effect on gender-specific cognitive functions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Yun Zhang, Shihui Fu, Ding Ding, Michael W. Lutz, Yi Zeng, Yao Yao
Summary: The study found significant associations between APOE ε4 and faster cognitive decline, as well as between engagement in leisure activities and mitigated cognitive decline. Moreover, there were significant interactions between APOE ε4 and leisure activities, particularly in relation to productive activities reducing the risk of APOE ε4-related cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Tianming Lai, Yin Zhu, Nonghua Lu, Wenhua He
Summary: This study investigates the impact of occasional or moderate alcohol consumption on the clinical outcomes of patients with hypertriglyceridemic pancreatitis (HTGP). The findings suggest that occasional or moderate alcohol consumption is associated with an increased risk of severe pancreatitis in HTGP patients, especially if alcohol is consumed within 48 hours before the onset of the disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Samantha A. A. Murphy, Ling Chen, Jason M. M. Doherty, Prerana Acharyya, Noah Riley, Ann M. M. Johnson, Alexis Walker, Hailee Domash, Maren Jorgensen, Sayeh Bayat, David B. B. Carr, Beau M. M. Ances, Ganesh M. M. Babulal
Summary: This study aimed to investigate whether cognitive reserve and brain reserve in cognitively normal older adults could predict changes in their driving behaviors. The findings suggest that increased hippocampal and whole brain atrophy, as well as lower cognitive reserve scores, were associated with changes in driving behaviors over time, indicating that individuals with lower brain and cognitive reserve may reduce their driving exposure and avoid highways.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Lindsey A. Hines, Hannah J. Jones, Matthew Hickman, Michael Lynskey, Laura Howe, Stan Zammit, Jon Heron
Summary: This study aimed to explore the association between adverse childhood experiences (ACEs) and the timing and frequency of cannabis use in adolescence. The findings showed that individuals with 4 or more ACEs, particularly those with parental substance use or abuse, were at a higher risk of problematic adolescent cannabis use. Therefore, reducing ACEs may help reduce cannabis use among adolescents.
LANCET PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Lizhen Han, Jinzhu Jia
Summary: The study found that alcohol consumption increases the risk of cognitive decline in older adults, especially for those with long-term drinking habits. It is recommended that older adults should avoid alcohol intake as much as possible.
Review
Nutrition & Dietetics
Silvana Hrelia, Laura Di Renzo, Luigi Bavaresco, Elisabetta Bernardi, Marco Malaguti, Attilio Giacosa
Summary: While alcohol abuse is harmful, moderate alcohol consumption, especially of wine, is associated with health benefits. This review evaluates the relationship between the type and dose of alcoholic drink and the risk of various diseases, and emphasizes the unique benefits of moderate wine consumption, particularly in a Mediterranean diet.
Article
Clinical Neurology
Zhang Yan, Zhang Yingjie, An Na, Qiu Qi, Li Wei, Wang Wenzheng, Sun Lin, Xiao Shifu
Summary: The study found that light-to-moderate alcohol consumption had no significant impact on the overall cognitive function and the risk of dementia in elderly men. Nonalcohol users performed better in certain cognitive areas.
BEHAVIOURAL NEUROLOGY
(2021)
Article
Environmental Sciences
Lizhen Han, Jinzhu Jia
Summary: This study explored the associations and potential interactions between demographic characteristics, alcohol consumption, life and atmospheric environment, and cognitive function in seniors. The results showed that alcohol consumption and air pollution had detrimental effects on cognition, while factors such as good education and balanced diet had positive effects. Interactions between different factors were also confirmed.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Clinical Neurology
Sandar Aye, Vincent Bouteloup, Ashley Tate, Anders Wimo, Ron Handels, Delphine Jean, Bengt Winblad, Linus Joensson
Summary: Health utility estimates for subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are limited, especially in biomarker-confirmed populations. This study provides health utility estimates for SCD and MCI, revealing a decline in HR-QoL over time in moderate and severe dementia, and a negative association between clinical stage and VAS. Amyloid-positive patients show a faster decline in health utility, emphasizing the importance of considering biomarker status in HR-QoL assessments.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Nutrition & Dietetics
Yun Zhang, Xurui Jin, Michael W. Lutz, Sang-Yhun Ju, Keyang Liu, Guang Guo, Yi Zeng, Yao Yao
Summary: The study found that individuals carrying the APOE e4 allele experienced faster cognitive decline, while high DDPI and daily fish intake were associated with slower cognitive decline. Additionally, frequent fish intake was more beneficial in mitigating cognitive decline among APOE e4 allele carriers, especially for women.
CLINICAL NUTRITION
(2021)
Article
Psychology, Clinical
Liliana P. Capitao, Robert Chapman, Nicola Filippini, Lucy Wright, Susannah E. Murphy, Anthony James, Philip J. Cowen, Catherine J. Harmer
Summary: This study investigated the neural effects of fluoxetine on emotional reactivity and cognitive reappraisal in adolescent depression. The results showed that depressed adolescents on placebo exhibited reduced visual activation to aversive pictures, while depressed adolescents on fluoxetine showed increased activation in response to aversive pictures.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Lars Nyberg, Micael Andersson, Anders Lundquist, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Naiara Demnitz, Christian A. Drevon, Sandra Duezel, Klaus P. Ebmeier, Paolo Ghisletta, Richard Henson, Daria E. A. Jensen, Rogier A. Kievit, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Anna Plachti, Sara Pudas, James M. Roe, Kathrine Skak Madsen, Cristina Sole-Padulles, Yasmine Sommerer, Sana Suri, Eniko Zsoldos, Anders M. Fjell, Kristine B. Walhovd
Summary: We found heterogeneity in regional-atrophy patterns through latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. Our findings suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
Article
Clinical Neurology
Tea Teras, Suvi Rovio, Jaana Pentti, Jenny Head, Mika Kivimaki, Sari Stenholm
Summary: Increasing and decreasing sleep difficulties may be associated with accelerated decline in cognitive function during retirement transition and post-retirement.
Editorial Material
Medicine, General & Internal
Severine Sabia, Archana Singh-Manoux
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Geriatrics & Gerontology
Benjamin Landre, Celine Ben Hassen, Mika Kivimaki, Mikaela Bloomberg, Aline Dugravot, Alexis Schniztler, Severine Sabia, Archana Singh-Manoux
Summary: This study examined changes in physical and mental functioning before the onset of frailty using repeat data spanning 25 years. The results showed that differences in trajectories of physical and mental functioning were observable 25 years before the onset of frailty. Furthermore, lower physical and mental functioning scores at age 50 were associated with an increased risk of developing frailty at older ages.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Mikaela Bloomberg, Aline Dugravot, Andrew Sommerlad, Mika Kivimaki, Archana Singh-Manoux, Severine Sabia
Summary: Education plays a crucial role in explaining sex differences in cognitive function, with middle-income countries showing larger disadvantages for females compared to the United States.
Article
Neurosciences
Julia Binnewies, Laura Nawijn, Andreas M. Brandmaier, William F. C. Baare, Carl-Johan Boraxbekk, Naiara Demnitz, Christian A. Drevon, Anders M. Fjell, Ulman Lindenberger, Kathrine Skak Madsen, Lars Nyberg, Anya Topiwala, Kristine B. Walhovd, Klaus P. Ebmeier, Brenda W. J. H. Penninx
Summary: This study found that lifestyle-related risk factors, such as obesity and alcohol use, are negatively associated with hippocampal and total grey matter volumes. Additionally, having multiple unhealthy lifestyle factors leads to a linear reduction in overall brain volume.
BRAIN RESEARCH BULLETIN
(2023)
Letter
Cardiac & Cardiovascular Systems
Adam G. Tabak, Naveed Sattar, Mika Kivimaki
Article
Multidisciplinary Sciences
Anya C. Topiwala, Thomas Nichols, Logan Z. J. Williams, Emma Robinson, Fidel P. Alfaro-Almagro, Bernd L. Taschler, Chaoyue Wang, Christopher J. Nelson, Karla M. Miller, Veryan Codd, Nilesh Samani, Stephen Smith
Summary: Telomeres form protective caps at the ends of chromosomes and their attrition is linked to biological aging. Short telomeres are associated with increased risk of neurological and psychiatric disorders, including dementia. The relationship between telomere length and neuroimaging markers is not well-defined.
Article
Multidisciplinary Sciences
Anya Topiwala, Kulveer Mankia, Steven Bell, Alastair Webb, Klaus P. Ebmeier, Isobel Howard, Chaoyue Wang, Fidel Alfaro-Almagro, Karla Miller, Stephen Burgess, Stephen Smith, Thomas E. Nichols
Summary: The potential association between neurodegenerative disease risk and gout is not fully understood. Here the authors showed that gout is causally related to several measures of brain structure which may explain their higher vulnerability to dementia. Studies of neurodegenerative disease risk in gout are contradictory. Relationships with neuroimaging markers of brain structure, which may offer insights, are uncertain. Here we investigated associations between gout, brain structure, and neurodegenerative disease incidence. Gout patients had smaller global and regional brain volumes and markers of higher brain iron, using both observational and genetic approaches. Participants with gout also had higher incidence of all-cause dementia, Parkinson's disease, and probable essential tremor. Risks were strongly time dependent, whereby associations with incident dementia were highest in the first 3 years after gout diagnosis. These findings suggest gout is causally related to several measures of brain structure. Lower brain reserve amongst gout patients may explain their higher vulnerability to multiple neurodegenerative diseases. Motor and cognitive impairments may affect gout patients, particularly in early years after diagnosis.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Melina Regy, Aline Dugravot, Severine Sabia, Elodie Bouaziz-Amar, Claire Paquet, Bernard Hanseeuw, Archana Singh-Manoux, Julien Dumurgier
Summary: This study found that ATN profiles are associated with mortality, with patients showing isolated evidence of neurodegeneration having a higher short-term mortality rate, and AD patients having the highest long-term mortality rate.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Letter
Cardiac & Cardiovascular Systems
Pyry N. Sipila, Mika Kivimaki
Article
Psychology, Biological
Anders M. Fjell, Oystein Sorensen, Yunpeng Wang, Inge K. Amlien, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Ilja Demuth, Christian A. Drevon, Klaus P. Ebmeier, Paolo Ghisletta, Rogier Kievit, Simone Kuehn, Kathrine Skak Madsen, Athanasia M. Mowinckel, Lars Nyberg, Claire E. Sexton, Cristina Sole-Padulles, Didac Vidal-Pineiro, Gerd Wagner, Leiv Otto Watne, Kristine B. Walhovd
Summary: Short sleep duration is not directly associated with brain health, and normal brains promote adequate sleep.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Cell Biology
Andrew Sommerlad, Mika Kivimaki, Eric B. Larson, Susanne Roehr, Kokoro Shirai, Archana Singh-Manoux, Gill Livingston
Summary: The increasing number of people with dementia globally highlights the urgent need to reduce its scale and impact. Lifetime social participation may play a crucial role in reducing dementia risk and could have implications for individual behavior and public health policy. However, more research is needed to fully understand the causal relationship.