PKR involvement in Alzheimer’s disease

Insulin resistance in Alzheimer's disease

(2017) Thomas Diehl et al.   Translational Research

Inhibition of Double-Stranded RNA-Dependent Protein Kinase Strongly Decreases Cytokine Production and Release in Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease

(2017) Julien Couturier et al.   JOURNAL OF ALZHEIMERS DISEASE

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?

(2016) Mariko Taga et al.   BRAIN PATHOLOGY

The kinase activity of PKR represses inflammasome activity

(2016) Howard CH Yim et al.   CELL RESEARCH

Drug Development of Small-Molecule Inhibitors of AD-Relevant Kinases as Novel Perspective Multitargeted Approach

(2016) V. Tell et al.   Current Alzheimer Research

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Dual Kinase Inhibition Affords Extended in vitro Neuroprotection in Amyloid-β Toxicity

(2016) Sarah Gourmaud et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease

(2016) J.-S. Zhang et al.   NEUROSCIENCE

p58IPK suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophages

(2016) Evgenii Boriushkin et al.   Scientific Reports

A small molecule targeting protein translation does not rescue spatial learning and memory deficits in the hAPP-J20 mouse model of Alzheimer’s disease

(2016) Erik C.B. Johnson et al.   PeerJ

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

(2015) Wiep Scheper et al.   ACTA NEUROPATHOLOGICA

Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer’s Disease

(2015) Wioletta Rozpedek et al.   CURRENT MEDICINAL CHEMISTRY

Further understanding of tau phosphorylation: implications for therapy

(2015) Miguel Medina et al.   Expert Review of Neurotherapeutics

PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE  4 Human Replacement Mice

(2015) Y. Segev et al.   JOURNAL OF NEUROSCIENCE

Effect of active Aβimmunotherapy on neurons in human Alzheimer's disease

(2015) Claire Paquet et al.   JOURNAL OF PATHOLOGY

Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease

(2015) S Kim et al.   MOLECULAR PSYCHIATRY

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory

(2015) Mark Halliday et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Mutations in a translation initiation factor identify the target of a memory-enhancing compound

(2015) Y. Sekine et al.   SCIENCE

PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model

(2015) F Mouton-Liger et al.   Cell Death & Disease

Neuroinflammation and Aβ Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation

(2015) Anne-Sophie Carret-Rebillat et al.   Scientific Reports

Specific Downregulation of Hippocampal ATF4 Reveals a Necessary Role in Synaptic Plasticity and Memory

(2015) Silvia Pasini et al.   Cell Reports

Further understanding of tau phosphorylation: implications for therapy

(2015) Miguel Medina et al.   Expert Review of Neurotherapeutics

Pro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer’s Disease

(2015) Claire Paquet et al.   Frontiers in Neurology

Pathways to Alzheimer's disease

(2014) J. Hardy et al.   JOURNAL OF INTERNAL MEDICINE

Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic β-cells

(2013) Shan-Shan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Inhibition of PKR protects against tunicamycin-induced apoptosis in neuroblastoma cells

(2013) Lauren S. Vaughn et al.   GENE

Blocking the eIF2  Kinase (PKR) Enhances Positive and Negative Forms of Cortex-Dependent Taste Memory

(2013) E. Stern et al.   JOURNAL OF NEUROSCIENCE

Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory

(2013) Mimi A. Trinh et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component

(2013) C. Tronel et al.   NEUROCHEMISTRY INTERNATIONAL

Cerebrospinal Fluid PKR Level Predicts Cognitive Decline in Alzheimer’s Disease

(2013) Julien Dumurgier et al.   PLoS One

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

(2012) François Mouton-Liger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Increased Cerebrospinal Fluid Levels of Double-Stranded RNA-Dependant Protein Kinase in Alzheimer's Disease

(2012) François Mouton-Liger et al.   BIOLOGICAL PSYCHIATRY

Pharmacological Inhibition of PKR in APPswePS1dE9 Mice Transiently Prevents Inflammation at 12 Months of Age but Increases Aβ42 Levels in the Late Stages of the Alzheimer’s Disease

(2012) Julien Couturier et al.   Current Alzheimer Research

Double-Stranded RNA-Activated Protein Kinase Is a Key Modulator of Insulin Sensitivity in Physiological Conditions and in Obesity in Mice

(2012) M. A. Carvalho-Filho et al.   ENDOCRINOLOGY

Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity

(2012) Shensi Shen et al.   MOLECULAR CELL

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

ApoE ε4 is associated with eIF2α phosphorylation and impaired learning in young mice

(2012) Yifat Segev et al.   NEUROBIOLOGY OF AGING

PKR-Dependent Inflammatory Signals

(2012) R. Kang et al.   Science Signaling

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

The PKR Activator PACT Is Induced by Aβ: Involvement in Alzheimer's Disease

(2011) Claire Paquet et al.   BRAIN PATHOLOGY

Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition

(2011) Ping Jun Zhu et al.   CELL

Modulation of Tau Phosphorylation by the Kinase PKR: Implications in Alzheimer's Disease

(2010) Anindita Bose et al.   BRAIN PATHOLOGY

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Interferon-β induces apoptosis in human SH-SY5Y neuroblastoma cells through activation of JAK-STAT signaling and down-regulation of PI3K/Akt pathway

(2010) Simona Dedoni et al.   JOURNAL OF NEUROCHEMISTRY

eIF2  Phosphorylation-Dependent Translation in CA1 Pyramidal Cells Impairs Hippocampal Memory Consolidation without Affecting General Translation

(2010) Z. Jiang et al.   JOURNAL OF NEUROSCIENCE

Activation of eukaryotic initiation factor-2α-kinases in okadaic acid-treated neurons

(2010) S.M. Kim et al.   NEUROSCIENCE

Could PKR inhibition modulate human neurodegeneration?

(2009) Jacques Hugon et al.   Expert Review of Neurotherapeutics

PKR, a cognitive decline biomarker, can regulate translationviatwo consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients

(2009) Milena Damjanac et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Neuronal Phosphorylated RNA-Dependent Protein Kinase in Creutzfeldt-Jakob Disease

(2009) Claire Paquet et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Double stranded RNA activated EIF2 α kinase (EIF2AK2; PKR) is associated with Alzheimer's disease

(2007) María J. Bullido et al.   NEUROBIOLOGY OF AGING