Article
Cell & Tissue Engineering
Busra Isik, Roman Thaler, Busra B. Goksu, Sabena M. Conley, Hayder Al-Khafaji, Arjunmohan Mohan, Mohsen Afarideh, Abdelrhman M. Abumoawad, Xiang Y. Zhu, James D. Krier, Ishran M. Saadiq, Hui Tang, Alfonso Eirin, LaTonya J. Hickson, Andre J. van Wijnen, Stephen C. Textor, Lilach O. Lerman, Sandra M. Herrmann
Summary: This study found that swine ARAS MSCs have decreased angiogenesis and increased senescence compared to healthy MSCs, and that HPC can mitigate MSC dysfunction, senescence, and DNA hydroxymethylation in ARAS MSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Yan Huang, Jianyang Liu, Jialin He, Fengbo Tan, Ming Lu, Fulai Yuan, Xuelin Zhu, Lingyu Kong
Summary: Oxidative stress is crucial in brain injury after intracerebral hemorrhage (ICH). Olfactory mucosa-derived mesenchymal stem cells (OM-MSCs) have potential for treating oxidative brain damage caused by ferroptosis after ICH. Curcumin preconditioning enhances the anti-oxidative activity of OM-MSCs, improving their therapeutic efficacy in ICH.
Article
Cell & Tissue Engineering
Haoran Shi, Zhishan Jin, Yan Mao, Ruilin Ma, Jianjian Cui, Zejun Yang, Jianwen Zhu, Hui Gao, Yin Zhao
Summary: Preeclampsia is a common complication of pregnancy that seriously jeopardizes the health of both mother and infant. Previous studies have shown that hypoxic preconditioning can enhance the viability and migration ability of placental mesenchymal stem cells (PMSCs) and this effect is mediated through the DANCR/miR-656-3p/HIF-1α pathway.
Review
Cell & Tissue Engineering
Jian-feng Zhou, Yu Xiong, Xiaodong Kang, Zhigang Pan, Qiangbin Zhu, Roland Goldbrunner, Lampis Stavrinou, Shu Lin, Weipeng Hu, Feng Zheng, Pantelis Stavrinou
Summary: Intracerebral hemorrhage is a highly destructive brain disease with main risk factors such as hypertension and drug abuse. Stem cells and exosomes are considered as new methods for treatment, but more clinical studies are needed to confirm their safety and efficacy.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Sajjad Shirazi, Chun-Chieh Huang, Miya Kang, Yu Lu, Sriram Ravindran, Lyndon F. Cooper
Summary: The study found that modulation of miRNA biosynthesis and regulation can influence osteoblastic differentiation of human mesenchymal stem cells (hMSCs).
SCIENTIFIC REPORTS
(2021)
Article
Orthopedics
Xing Guo, Denghua Huang, Dan Li, Longfei Zou, Hui Lv, Yuanhui Wang, Meiyun Tan
Summary: This study found that hypoxia preconditioning attenuates the proliferation and migration ability of ADSCs, but has positive impact on tenogenic differentiation through HIF-1 alpha signaling pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Cell & Tissue Engineering
Fengyun Zhang, Fei Gao, Kun Wang, Xiaohong Liu, Zhuoqi Zhang
Summary: This study found that miR-34a is significantly increased under chronic hyperglycemia exposure, leading to impaired MSCs viability, exacerbated senescence, and disrupted paracrine capacity. The mechanism involves the activation of the SIRT1/FoxO3a autophagy pathway by miR-34a in MSCs exposed to high glucose, resulting in deterioration of cell function. Inhibiting miR-34a may hold therapeutic promise for MSC-based therapies in diabetic patients with myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Liqiang Sun, Wenlong Zhang
Summary: The study demonstrates that preconditioning MSCs with ghrelin can enhance cardioprotective effects, especially in elderly subjects, following IR injury. Preconditioned MSCs increase autophagy flux by downregulating Beclin-1 and P62 protein overexpression, and increasing LC3-II expression and the LC3-II/LC3-I ratio. Moreover, combining NMN with ghrelin-preconditioned MSCs synergistically enhances protective effects on infarct size and mitochondrial function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Jun Ying, Qing You, Zhiguo Wang, Zhiqian Hu
Summary: This study suggests that preconditioning mesenchymal stem cells under hypoxic conditions can enhance their therapeutic effect in treating inflammatory bowel disease.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Guanghao Wu, Zhenya Liu, Changwen Mu, Da Song, Jiaxin Wang, Xiangxi Meng, Ziyuan Li, Hong Qing, Yuping Dong, Hai-Yan Xie, Dai-Wen Pang
Summary: Hybrid cells that fused MSCs with platelets and loaded with LPA-QDs were fabricated for efficient ICH therapy. These cells not only inherited the capabilities of both platelets and MSCs but also exhibited enhanced proliferation. The treatment process can be tracked by near-infrared II fluorescence imaging.
Review
Neurosciences
Guoqiang Yang, Xuehui Fan, Maryam Mazhar, Sijin Yang, Houping Xu, Nathupakorn Dechsupa, Li Wang
Summary: Intracerebral hemorrhage (ICH), a subtype of stroke with high mortality and disability rates, has a major socioeconomic burden, affecting two million people worldwide. Mesenchymal stem cells (MSCs) have shown potential in ICH treatment due to their neuroprotective, anti-inflammatory, and angiogenesis properties. This research field is important for developing new therapeutic strategies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kanwal Haneef, Asmat Salim, Zehra Hashim, Amber Ilyas, Basir Syed, Aftab Ahmed, Shamshad Zarina
Summary: This study investigated the mechanism by which hypoxic preconditioning enhances the survival of mesenchymal stem cells (MSCs). Proteomic analysis revealed higher expression of certain proteins in hypoxic preconditioned (HP) MSCs, which are possibly involved in cellular survival and proliferation through various cellular pathways. This research is important for understanding the processes involved in hypoxic preconditioning of MSCs and designing cell-based therapeutic strategies for tissue regeneration.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Seiko Harada, Yo Mabuchi, Jun Kohyama, Daisuke Shimojo, Sadafumi Suzuki, Yoshimi Kawamura, Daisuke Araki, Takashi Suyama, Masunori Kajikawa, Chihiro Akazawa, Hideyuki Okano, Yumi Matsuzaki
Summary: The study compared gene expression profiles of immature hMSCs and less potent MSCs to explore the molecular mechanisms regulating senescence in hMSCs. It was found that FZD5, a transcription factor expressed specifically in immature hMSCs, plays a crucial role in regulating senescence by promoting proliferation and delaying cell cycle arrest. Controlling FZD5 signaling may offer potential to improve hMSC quality for cell-replacement therapies.
Article
Cell Biology
Miyeon Kim, Jinyoung Go, Ji Hye Kwon, Hye Jin Jin, Yun Kyung Bae, Eun-Young Kim, Eun-Ju Chang, Soo Jin Choi, Seong Who Kim
Summary: This study found that the gene CD26 is significantly upregulated during cellular aging of umbilical cord blood-derived MSCs. Inhibiting CD26 delays cellular aging and enhances therapeutic efficacy of MSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Yu-hua Gong, Shi-lei Hao, Bo-chu Wang
Summary: Intracerebral hemorrhage (ICH) is a leading cause of death and long-term disability worldwide. Research has shown that mesenchymal stem cell (MSC) therapy can improve neuronal defects caused by ICH, but key issues regarding the survival, differentiation, and safety of grafted MSCs still need to be resolved for clinical translation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)