Article
Biochemistry & Molecular Biology
Ming-Luen Hu, Wei-Shiung Lian, Feng-Sheng Wang, Chao-Hui Yang, Wan-Ting Huang, Jing-Wen Yang, I-Ya Chen, Ming-Yu Yang
Summary: Recent studies have shown that dysbiosis is associated with inflammatory bowel disease (IBD). Trying to restore microbial diversity via fecal microbiota transplantation (FMT) or probiotic intervention fails to achieve clinical benefit in IBD patients. This study performed a probiotic intervention on a simulated IBD murine model and found that the intervention changed microbial composition but did not improve colitis and colitis-associated neoplasms, and even caused dysbiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Min Seo Kim, Yong Dae Kim, Seunghee Kang, Oran Kwon, Jae-Ho Shin, Ji Yeon Kim
Summary: In this study, the effect of cinnamon subcritical water extract (CSE) on gut health in a mouse colitis model induced by dextran sodium sulfate was evaluated. Results showed that CSE improved clinical symptoms, reduced inflammatory markers, increased expression of tight junction proteins, and altered the microbiome to reduce inflammation. These findings suggest that CSE could prevent colitis-induced intestinal disruption.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Pratik Thapa, Hong Jiang, Na Ding, Yanning Hao, Aziza Alshahrani, Eun Y. Lee, Junichi Fujii, Qiou Wei
Summary: Peroxiredoxin IV (Prx4) functions as an antioxidant to maintain cellular redox homeostasis. Loss of Prx4 leads to increased cell death and decreased infiltration of inflammatory cells in colon tumors. Targeting Prx4 may provide novel strategies for colon cancer prevention and treatment.
Article
Biochemistry & Molecular Biology
Xuejun Zeng, Hang Jia, Xiao Zhang, Xin Wang, Zhouli Wang, Zhenpeng Gao, Yahong Yuan, Tianli Yue
Summary: The study demonstrated that kefir can improve colorectal cancer by regulating microbiota composition, reducing tumor size and number, and decreasing inflammation and tumor cell proliferation indicators.
Article
Microbiology
Hao-Ming Xu, Hong-Li Huang, Yan-Di Liu, Jia-Qi Zhu, You-Lian Zhou, Hui-Ting Chen, Jing Xu, Hai-Lan Zhao, Xue Guo, Wei Shi, Yu-Qiang Nie, Yong-Jian Zhou
Summary: DSS-induced acute and chronic colitis in mice showed similar symptoms and histopathological changes. The gut microbiota changes in the acute colitis model were closer to those observed in UC, with a greater abundance of SCFAs-producing bacteria and lower alpha-diversity compared to the chronic colitis model.
Article
Food Science & Technology
Hyeon-Ji Lim, Ha-Rim Kim, Su-Ji Jeong, Hee-Jong Yang, Myeong Seon Ryu, Do-Youn Jeong, Seon-Young Kim, Chan-Hun Jung
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease with increasing incidence due to changes in dietary structure. Recent evidence suggests that gut dysbiosis is closely associated with the pathogenesis of IBD. Cheonggukjang, a traditional Korean fermented soybean paste, contains probiotics that may affect the gut microbiota composition and potentially protect against IBD. This study found that traditional and commercial Cheonggukjang samples contain various types of beneficial probiotics. Cheonggukjang reduced the progression of DSS-induced colitis symptoms and improved intestinal barrier integrity. It also suppressed the expression of proinflammatory cytokines and inflammatory mediators through the inactivation of NF-kappa B and MAPK signaling pathways. These findings suggest that Cheonggukjang has protective effects against DSS-induced colitis and may be used as a functional food for improving inflammatory diseases.
Article
Biochemistry & Molecular Biology
Ji-Hyun Lee, Yong-Deok Jeon, Mingjie Xin, Ji-ye Lim, Young-Mi Lee, Dae-Ki Kim
Summary: Mast cells play an important role in the development and growth of colon cancer by regulating pro-inflammatory cytokines and inflammatory mediators.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Oncology
Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jeong Eun Yu, Heewon Nho, Eun Shin, Ha-Na Lee, Young-Joon Surh
Summary: The study examined the effects of orchiectomy and testosterone administration on colorectal tumorigenesis in a mouse model. Orchiectomy reduced colitis indices and tumor incidence, which was reversed by testosterone supplementation. Both endogenous and exogenous testosterone were associated with tumor development, supporting a stimulating effect on colorectal carcinogenesis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Jie Zhang, Zhewen Chen, Yanwen Lu, Daoyuan Tu, Fengqian Zou, Shouwen Lin, Weinan Yu, Mingyong Miao, Hanping Shi
Summary: The study found that the functional food significantly inhibited the growth of colorectal cancer by improving nutritional status, enhancing intestinal barrier function, regulating the tumor microenvironment, and altering the gut microbiota and metabolites.
ONCOTARGETS AND THERAPY
(2021)
Article
Immunology
Bo Zeng, Yuanting Huang, Siyuan Chen, Rong Xu, Lihui Xu, Jiahao Qiu, Fuli Shi, Siying Liu, Qingbing Zha, Dongyun Ouyang, Xianhui He
Summary: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, has been on the rise in recent years. A study has found that the KCa3.1 channel plays a critical role in mediating DSS-induced colitis in mice by enhancing the activation of NLRP3 inflammasome, leading to the occurrence of inflammatory injuries.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ji Eun Yeom, Sung-Kyu Kim, So-Young Park
Summary: beta-Caryophyllene (BCP), a natural compound derived from cloves, has shown potential in treating ulcerative colitis by increasing stool weight, restoring gut motility, increasing colon length, and reducing inflammatory cytokines levels.
Article
Reproductive Biology
Lei-Ning Chen, Tao Jing, Zi-Bin Lin, Wei Song, Wen-Hao Du, Xiao-Yan Fan, Chao Li, Sen Li, Feng-Yun Xie, Xiang-Hong Ou, Lin Huang, Jun-Yu Ma
Summary: Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis, are prevalent in developed countries and increasing in developing countries. Evidence suggests that individuals with CD have lower levels of serum testosterone, but the effects of IBD on testicular testosterone synthesis are not well understood. Using a mouse model, this study analyzed testicular metabolome and transcriptome data to investigate the effects of IBD on the testis. The results showed that IBD induced a decrease in testicular androgen levels and down-regulation of androgen synthesis-associated genes. Changes in specific metabolites and transcripts were identified, providing potential targets for IBD treatment or symptom relief.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Immunology
Yoshiyuki Kimura, Maho Sumiyoshi, Masahiko Taniguchi
Summary: This study investigates the effects of geniposide, isolated from Gardenia jasminoides fructus, on colon tumor growth. The results show that geniposide significantly inhibits the growth of colorectal tumors and reduces the levels of inflammatory factors and cell death-related proteins in the colon.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rita Bonfiglio, Filippo Galli, Michela Varani, Manuel Scimeca, Filippo Borri, Sara Fazi, Rosella Cicconi, Maurizio Mattei, Giuseppe Campagna, Tanja Schoenberger, Ernest Raymond, Andreas Wunder, Alberto Signore, Elena Bonanno
Summary: This study developed a reliable murine model of inflammatory bowel disease (IBD) and conducted histological characterization and immunohistochemical analyses to provide important data for preclinical studies aimed at improving personalized management of IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Seung-Hyeon Lee, Ha-Rim Kim, Eun-Mi Noh, Jae Young Park, Mi-Sun Kwak, Ye-Jin Jung, Hee-Jong Yang, Myeong Seon Ryu, Hyang-Yim Seo, Hansu Jang, Seon-Young Kim, Mi Hee Park
Summary: The study investigated the effect of Glycine max hydrolyzed with enzymes from Bacillus velezensis KMU01 on DSS-induced colitis in mice. The results showed that orally administered enzymatically hydrolyzed G. max alleviated body weight loss and reduced disease activity index and colon length. It also decreased the production of inflammatory cytokines and improved histological changes and intestinal barrier integrity. Additionally, the abundance of certain microorganisms associated with inflammatory bowel diseases decreased after EHG treatment. Overall, EHG has a protective effect against colitis and could be a potential treatment option.
Article
Immunology
Qiang Shan, Sheng'en Hu, Xia Chen, Derek B. Danahy, Vladimir P. Badovinac, Chongzhi Zang, Hai-Hui Xue
Summary: The study demonstrates that ectopic Tcf1 expression promotes the generation of stem cell-like Tex cells in chronic viral infection and tumor models, enhancing their functionality and response to checkpoint blockade. This highlights the therapeutic potential of harnessing Tcf1-enforced transcriptional programs for viral and tumor control.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Valeria Tosello, Deborah Bongiovanni, Jingjing Liu, Qingfei Pan, Koon-kiu Yan, Valentina Saccomani, Maaike Van Trimpont, Marco Pizzi, Martina Mazzoni, Angelo Paolo Dei Tos, Alberto Amadori, Paola Zanovello, Pieter Van Vlierberghe, Jiyang Yu, Erich Piovan
Summary: Therapeutic targeting of GLI transcription factors by GANT-61 is effective against NOTCH1 unmutated T-ALL cells, as GLI1 contributes to T-ALL progression through modulation of AKT and CXCR4 signaling pathways. There is also a novel cross-talk between GLI factors and FOXC1, where FOXC1 can stabilize GLI1/2 protein levels.
Article
Immunology
Pengcheng Du, Chuan Song, Rui Li, Yangzi Song, Jiarui Li, Nan Ding, Ju Zhang, Rui Song, Junyan Han, Guiju Gao, Jinglin Yue, Ang Duan, Yanyi Huang, Jing An, Jianbin Wang, Fujie Zhang, Chen Chen, Hui Zeng
Summary: Intrahost analysis of SARS-CoV-2 genomic sequences identified 2 viral haplotypes with 3 genetically linked mutations from a patient's respiratory and intestinal tracts. The spatiotemporal data suggest that the patient initially had dual infection of 2 SARS-CoV-2 variants, which then redistributed into the two systems.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Yangzi Song, Chen Chen, Yu Wang, Ju Zhang, Meiling Chen, Guiju Gao, Sa Wang, Di Yang, Rui Song, Linghang Wang, Wen Xie, Fengting Yu, Liting Yan, Yajie Wang, Hui Zeng, Fujie Zhang
Summary: The study highlights the importance of early, consecutive, and combined double testing in identifying infected patients, especially for asymptomatic and mild symptomatic cases, to minimize misdiagnosis and ineffective isolation of infected patients in the absence of effective treatments or vaccines.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Cell Biology
Victoria Zyulina, Koon-Kiu Yan, Bensheng Ju, Elke Schwarzenberger, Christina Passegger, Carmen Tam-Amersdorfer, Qingfei Pan, Tommaso Sconocchia, Christian Pollack, Bridget Shaner, Armin Zebisch, John Easton, Jiyang Yu, Jose M. Silva, Herbert Strobl
Summary: The TGF-beta family ligands play a crucial role in dendritic cell differentiation and activation. Through investigating differentially expressed microRNAs, it was found that miR-424/503 is significantly inversely regulated between moDCs and LCs. Further study revealed that miR-424/503 induction promotes moDC differentiation, while its repression facilitates TGF-beta 1-dependent LC differentiation from monocytes.
Letter
Biology
Junyan Han, Ning Zhang, Danying Chen, Yuhuan Gong, Guoli Li, Yaxian Kong, Lin Pu, Chen Chen, Jingyuan Liu, Qi Wang, Ju Zhang, Xuesen Zhao, Juan Du, Kai Han, Chuan Song, Linghang Wang, Mingxi Hua, Yu Hao, Rui Song, Yangzi Song, Fengting Yu, Siyuan Yang, Haofeng Xiong, Wei Zhang, George F. Gao, Fujie Zhang, Ang Li, Hui Zeng, Yuhai Bi
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Genetics & Heredity
Jing Fu, Ju Zhang, Li Yang, Nan Ding, Liya Yue, Xiangli Zhang, Dandan Lu, Xinmiao Jia, Cuidan Li, Chongye Guo, Zhe Yin, Xiaoyuan Jiang, Yongliang Zhao, Fei Chen, Dongsheng Zhou
Summary: The study systematically investigated the methylation features of Klebsiella pneumoniae and identified 15 methylation motifs. The distribution patterns of these motifs in the genome were analyzed and the methylation dynamics were characterized at single-base resolution. The findings provide useful insights into the epigenetic regulation of K. pneumoniae and other bacterial species.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Cell Biology
Jiarui Li, Pengcheng Du, Lijiang Yang, Ju Zhang, Chuan Song, Danying Chen, Yangzi Song, Nan Ding, Mingxi Hua, Kai Han, Rui Song, Wen Xie, Zhihai Chen, Xianbo Wang, Jingyuan Liu, Yanli Xu, Guiju Gao, Qi Wang, Lin Pu, Lin Di, Jie Li, Jinglin Yue, Junyan Han, Xuesen Zhao, Yonghong Yan, Fengting Yu, Angela R. Wu, Fujie Zhang, Yi Qin Gao, Yanyi Huang, Jianbin Wang, Hui Zeng, Chen Chen
Summary: This study analyzes clinical samples from patients with COVID-19 and finds that genetic diversity increases in individuals after symptom onset. Nonsynonymous mutations are more common within individuals but less prevalent at the population level, suggesting a two-step fitness selection process. Dynamic changes in iSNVs among different populations indicate differences in the fitness selection process.
Article
Chemistry, Multidisciplinary
Fengzhen Cui, Qingfei Pan, Siyi Wang, Faming Zhao, Runxin Wang, Tingting Zhang, Yaying Song, Jun He, Haolin Zhang, Qiang Weng, Yang Jin, Wei Xia, Yuanyuan Li, Guo-Yuan Yang, Winnok H. De Vos, Jean-Pierre Timmermans, Shunqing Xu, Yaohui Tang, Xia Sheng
Summary: The study reveals the neurodevelopmental toxicity of benzophenones during pregnancy, which impairs hippocampal development and causes cognitive dysfunction in offspring mice by activating specific signaling pathways that lead to inflammation and cell apoptosis.
Article
Immunology
Jia Liu, Shaoqi Zhu, Wei Hu, Xin Zhao, Qiang Shan, Weiqun Peng, Hai-Hui Xue
Summary: Xue, Peng, and colleagues used multiomics approaches including Hi-C to demonstrate that CTCF promotes cytotoxic effector differentiation through dynamic redistribution, local chromatin accessibility control, and higher-order genomic reorganization, while enclosing memory precursor-associated genes within insulated neighborhoods to restrain their activation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Cell Biology
Beibei Wang, Liuluan Zhu, Bei Jia, Chenchen Zhao, Ju Zhang, Fangyuan Li, Jiarui Li, Nan Ding, Can Zhang, Yu Hao, Shuai Tong, Jiajia Wang, Guoli Li, Yang Fan, Henghui Zhang, Rui Li, Juan Du, Yaxian Kong, Yue Zhang, Xiaoyu Yang, Junyan Han, Zhengya Yu, Zhongtao Du, Hong Zheng, Christian Kosan, Ang Li, Chen Chen, Yaluan Ma, Hui Zeng
Summary: In patients with sepsis, secondary infection triggers a new wave of inflammatory response, worsening organ damage and increasing mortality. Primary infection reprograms granulocytes to enhance their inflammatory response to secondary infection, but these reprogrammed granulocytes exhibit non-classic characteristics of innate immune memory.
Review
Immunology
Xudong Zhao, Qiang Shan, Hai-Hui Xue
Summary: TCF1 plays essential roles in early T cell development and exhibits versatile, context-dependent functions in mature T cells. It is required for the self-renewal of stem-like CD8(+) T cells and regulates T cell responses effectively.
NATURE REVIEWS IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ju Zhang, Nan Ding, Yangzi Song, Rui Song, Yang Pan, Linghang Wang, Shuo Yan, Qi Wang, Shanfang Ma, Lirong Wei, Fengting Yu, Lianhe Lu, Fujie Zhang, Chen Chen, Hui Zeng
Summary: The study traced asymptomatic transmission of COVID-19 patients using a novel sequencing technology and provided phylogenomic evidence. The findings suggest that current screening measures may need to consider covering asymptomatic individuals.
Article
Biology
Keyin Zhang, Ju Zhang, Nan Ding, Lucas Zellmer, Yan Zhao, Siqi Liu, Dezhong Joshua Liao
Summary: Through polyacrylamide gel electrophoresis and LC-MS/MS, the identities of ACTB and GAPDH proteins were determined, indicating they are not suitable as reference genes for determining protein loading in techniques like Western blotting.
OPEN LIFE SCIENCES
(2021)
Meeting Abstract
Oncology
Qingfei Pan, Tizita Zeleke, Cody Chiuzan, Maika Onishi, Mariano Alvarez, Erin Honan, Min Yang, Pei Ling Chia, Partha Mukhopadhyay, Sean Kelly, Ruby Wu, Kathleen Fenn, Meghna Trivedi, Melissa Accordino, Katherine Crew, Dawn Hershman, Matthew Maurer, Simon Jones, Andrea Califano, Kevin Kalinsky, Jiyang Yu, Jose Silva