A novel bi-domain plant defensin MtDef5 with potent broad-spectrum antifungal activity binds to multiple phospholipids and forms oligomers

Structure of the defensin NsD7 in complex with PIP2 reveals that defensin : lipid oligomer topologies are dependent on lipid type

(2017) Michael Järvå et al.   FEBS LETTERS

Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action

(2017) Judith Raschig et al.   PLoS Pathogens

Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant

(2016) Mark R. Bleackley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antifungal mechanisms of a plant defensin MtDef4 are not conserved between the ascomycete fungiNeurospora crassaandFusarium graminearum

(2016) Kaoutar El-Mounadi et al.   MOLECULAR MICROBIOLOGY

Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin–lipid oligomeric assemblies and membrane permeabilization

(2016) Marc Kvansakul et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding

(2016) Justin A. Boddey et al.   Nature Communications

Plant cysteine-rich peptides that inhibit pathogen growth and control rhizobial differentiation in legume nodules

(2015) Gergely Maróti et al.   CURRENT OPINION IN PLANT BIOLOGY

The Tomato Defensin TPP3 Binds Phosphatidylinositol (4,5)-Bisphosphate via a Conserved Dimeric Cationic Grip Conformation To Mediate Cell Lysis

(2015) Amy A. Baxter et al.   MOLECULAR AND CELLULAR BIOLOGY

Antifungal Plant Defensins: Mechanisms of Action and Production

(2014) Kim Vriens et al.   MOLECULES

Multitasking antimicrobial peptides in plant development and host defense against biotic/abiotic stress

(2014) Ravinder K. Goyal et al.   PLANT SCIENCE

Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

(2014) Ivan KH Poon et al.   eLife

Identification and Mechanism of Action of the Plant Defensin NaD1 as a New Member of the Antifungal Drug Arsenal against Candida albicans

(2013) Brigitte M. E. Hayes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Properties and mechanisms of action of naturally occurring antifungal peptides

(2013) Nicole L. van der Weerden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Structural and Functional Studies of a Phosphatidic Acid-Binding Antifungal Plant Defensin MtDef4: Identification of an RGFRRR Motif Governing Fungal Cell Entry

(2013) Uma Shankar Sagaram et al.   PLoS One

The Essential Phosphoinositide Kinase MSS-4 Is Required for Polar Hyphal Morphogenesis, Localizing to Sites of Growth and Cell Fusion in Neurospora crassa

(2012) Anette Mähs et al.   PLoS One

Human  -Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

(2012) H. Chu et al.   SCIENCE

Plant defensins: Common fold, multiple functions

(2012) Nicole L. van der Weerden et al.   Fungal Biology Reviews

Modes of antifungal action and in planta functions of plant defensins and defensin-like peptides

(2012) Barbara De Coninck et al.   Fungal Biology Reviews

Structure-Activity Determinants in Antifungal Plant Defensins MsDef1 and MtDef4 with Different Modes of Action against Fusarium graminearum

(2011) Uma Shankar Sagaram et al.   PLoS One

Can plant defensins be used to engineer durable commercially useful fungal resistance in crop plants?

(2011) Jagdeep Kaur et al.   Fungal Biology Reviews

Antifungal Activity of PvD1 Defensin Involves Plasma Membrane Permeabilization, Inhibition of Medium Acidification, and Induction of ROS in Fungi Cells

(2010) Erica O. Mello et al.   CURRENT MICROBIOLOGY

Permeabilization of Fungal Hyphae by the Plant Defensin NaD1 Occurs through a Cell Wall-dependent Process

(2010) Nicole L. van der Weerden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plant defensins—Prospects for the biological functions and biotechnological properties

(2009) André de Oliveira Carvalho et al.   PEPTIDES

The mode of antifungal action of plant, insect and human defensins

(2008) A. M. Aerts et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Plant Defensin, NaD1, Enters the Cytoplasm ofFusarium OxysporumHyphae

(2008) Nicole L. van der Weerden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY