Zinc triflate-mediated cyclopropanation of oxindoles with vinyl diphenyl sulfonium triflate: a mild reaction with broad functional group compatibility

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Facile synthesis of aza-spirocyclopropanyl oxindoles by the reaction of 3-(2-bromoethyl)-indole with 2,3-dimethylimidazole-1-sulfonyl azide triflate

(2016) Mei-Hua Shen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity

(2016) M. Palomba et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bismuth Acetate as a Catalyst for the Sequential Protodeboronation of Di- and Triborylated Indoles

(2016) Fangyi Shen et al.   ORGANIC LETTERS

Nickel(ii)-catalyzed enantioselective cyclopropanation of 3-alkenyl-oxindoles with phenyliodonium ylide via free carbene

(2016) Jing Guo et al.   Chemical Science

Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization

(2015) Kevin J. Frankowski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Spirooxindoles: Promising scaffolds for anticancer agents

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Construction of Spirocyclopropane-Linked Heterocycles Containing Both Pyrazolones and Oxindoles through Michael/Alkylation Cascade Reactions

(2015) Jun-Hua Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Manganese-Catalyzed Late-Stage Aliphatic C–H Azidation

(2015) Xiongyi Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-catalysed azidation of tertiary C–H bonds suitable for late-stage functionalization

(2015) Ankit Sharma et al.   NATURE

Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization

(2015) Song Song et al.   ORGANIC LETTERS

Catalytic asymmetric synthesis of polysubstituted spirocyclopropyl oxindoles: organocatalysis versus transition metal catalysis

(2015) Zhong-Yan Cao et al.   Organic Chemistry Frontiers

The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diastereoselective Synthesis of Functionalized Spirocyclopropyl Oxindoles via P(NMe2)3-Mediated Reductive Cyclopropanation

(2014) Rong Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist

(2013) Jennifer X. Qiao et al.   JOURNAL OF MEDICINAL CHEMISTRY

A general access to 1,1-cyclopropane aminoketones and their conversion into 2-benzoyl quinolines

(2012) Zhenjun Mao et al.   CHEMICAL COMMUNICATIONS

Epoxy-Annulations by Reactions of α-Amido Ketones with Vinyl Sulfonium Salts. Reagent versus Substrate Control and Kinetic Resolution

(2008) Matthew G. Unthank et al.   ORGANIC LETTERS