Article
Food Science & Technology
Yang Li, Fengying Gu, Xin Guo, Qiaozhen Zhang, Runrun Hu, Ling Qin, Qiang Wang, Feng Wang
Summary: This paper assessed the impact of different drying methods (hot air drying, freeze drying, vacuum drying, and microwave drying) on the content of bioactive substances and the digestion and absorption characteristics of Ganoderma lucidum fermented whole wheat (GW) products. The results showed that freeze drying, vacuum drying, and hot air drying were beneficial for retaining unstable substances in GW, while microwave drying had lower content. The bioavailability of polysaccharides in the microwave drying group was significantly higher, but the bioaccessibility was lower compared to the other drying methods. Principal component analysis indicated that vacuum drying was more suitable for GW drying.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Weiming Shao, Chun Xiao, Tianqiao Yong, Yifan Zhang, Huiping Hu, Ting Xie, Rongjie Liu, Longhua Huang, Xiangmin Li, Yizhen Xie, Jumei Zhang, Shaodan Chen, Manjun Cai, Diling Chen, Yuanchao Liu, Xiong Gao, Qingping Wu
Summary: In this study, a thermal stable and non-toxic heteropolysaccharide F31 was found to have remarkable hypoglycemic effects on diabetic mice. It repaired islet cells, increased insulin secretion, promoted glycogen synthesis and storage in the liver, and improved antioxidant enzyme activities and insulin resistance. Furthermore, F31 regulated the metabolism of gut microbiota to a normal state, which may contribute to its beneficial effects against hyperglycemia.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Cuiling Guo, Dandan Guo, Liu Fang, Tingting Sang, Jianjun Wu, Chengjie Guo, Yujie Wang, Ying Wang, Chaojie Chen, Jiajun Chen, Rong Chen, Xingya Wang
Summary: The study found that GLP can reduce AOM/DSS-induced colitis and tumorigenesis, improve dysbiosis, increase short-chain fatty acid production, and enhance gut barrier function.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Yu Xiong, Feng-Li Zhang, Jing-Ru Li, Pei-Zhi Peng, Bin Liu, Li-Na Zhao
Summary: The study evaluates the effects of Ganoderma lucidum protease hydrolysate (GLPH) on lipid metabolism and intestinal flora in rats fed a high-fat diet. The results show that GLPH reduces triglycerides, total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, and aspartate aminotransferase levels, while increasing high-density lipoprotein cholesterol. GLPH also alters the composition of intestinal flora and reduces the abundance of potentially harmful bacteria.
Article
Chemistry, Applied
Tingting Sang, Chengjie Guo, Dandan Guo, Jianjun Wu, Yujie Wang, Ying Wang, Jiajun Chen, Chaojie Chen, Kaikai Wu, Kun Na, Kang Li, Liu Fang, Cuiling Guo, Xingya Wang
Summary: The study found that polysaccharide extracted from the sporoderm-broken spores of Ganoderma lucidum (BSGLP) could inhibit obesity and hyperlipidemia by modulating inflammation, gut microbiota, and gut barrier function. This polysaccharide showed potential as a prebiotic agent against obesity and hyperlipidemia.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Fengli Zhang, Wenqi Huang, Lina Zhao
Summary: This preliminary study investigates the modulatory effects of a formulation containing Ganoderma lucidum, Grifola frondosa, and American ginseng on gut microbiota and fecal metabolism. The findings suggest that the immune enhancement observed with JGGA may be attributed to the targeted modulation of gut microbiota and fecal metabolism, thus promoting increased immunity in the body.
Article
Multidisciplinary Sciences
Jiajia Wang, Junfeng Pu, Zhixian Zhang, Zean Feng, Jing Han, Xiaojie Su, Lei Shi
Summary: This study evaluated the anti-tumor effect of triterpenoids of Ganoderma lucidum (TGL) on S180 and H22 tumor bearing mice. The results showed that TGL had inhibition rates higher than 40% in tumor bearing mice. TGL had protective effects on the spleen and thymus, improved lipid peroxidation, down-regulated Bcl-2, upregulated Bax, and improved gut microbiota.
Article
Biochemistry & Molecular Biology
Chung-Hsiung Huang, Tzu-Yu Chen, Guo-Jane Tsai
Summary: This study investigated the hypouricemic effects of submerged culture of Ganoderma lucidum. The results demonstrated the stronger hypouricemic effect of the submerged culture's mycelium, as well as the effectiveness of the extracellular polysaccharides in improving renal and hepatic function.
Article
Nutrition & Dietetics
Sandra L. Romero-Cordoba, Ivan Salido-Guadarrama, Maria E. Meneses, Giulia Cosentino, Marilena V. Iorio, Elda Tagliabue, Nimbe Torres, Monica Sanchez-Tapia, Myrna Bonilla, Ivan Castillo, Beatriz Petlacalco, Armando R. Tovar, Daniel Martinez-Carrera
Summary: The study reveals that Ganoderma lucidum extracts modulate metabolic pathways related to lipid biosynthesis and degradation, with Gl-2 extract showing a major modulation over gene expression programs similar to simvastatin druggable-target-genes enriched in processes related to human obesity alterations in the liver. Additionally, certain Gl-modulated genes are correlated with Lactobacillus enrichment and the reduction of circulating cholesterol-derived fats. The extracts also induce a decrease in macrophage lipid storage, suggesting a new link between Gl's hypocholesterolemic and prebiotic activity in preventing metabolic disorders associated with hypercholesterolemia.
Article
Immunology
Jiaqi Zhang, Siyi Cheng, Jinsong Liang, Juanjuan Qu
Summary: In this study, polysaccharide extracted from mycelium of Inonotus obliquus (IOP) was found to alleviate the symptoms of UC by increasing body weight, colon length, superoxide dismutase (SOD) activity, while decreasing malondial-dehyde (MDA) content, myeloperoxidase (MPO) activity, and the concentration of nitric oxide (NO). IOP treatment also modulated the secretion of interleukins and the gut microbiota composition.
MICROBIAL PATHOGENESIS
(2023)
Review
Nutrition & Dietetics
Natasha K. Leeuwendaal, Catherine Stanton, Paul W. O'Toole, Tom P. Beresford
Summary: Fermented foods have been a part of human diet for thousands of years and have a diverse range in the 21st century. Research has shown that bioactive peptides and microbial metabolites in fermented foods have positive effects on human health. Each type of fermented food hosts a specific population of microorganisms, which can survive in the gut and interact with the gut microbiome. This review examines the fermentation process, microorganisms involved, potential health benefits, and the impact of fermented foods on the gut microbiome.
Article
Food Science & Technology
Ming Cai, Hua Mu, Haoyong Xing, Zhenhao Li, Jing Xu, Wei Liu, Kai Yang, Peilong Sun
Summary: The study found that Ganoderma lucidum spores with the sporoderm removed showed stronger metabolic promotion effects and better anti-inflammatory properties after in vitro digestion.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Zhengyu Ren, Zhenzhen Xu, William Kwame Amakye, Wei Liu, Zikuan Zhao, Li Gao, Min Wang, Jiaoyan Ren
Summary: This study validates the occurrence of spontaneous UC in cynomolgus monkeys and explores the potential of Hericium erinaceus mycelium-derived polysaccharide in reversing UC pathologies.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zhen Dai, Gaoheng Li, Xixi Wang, Bo Gao, Xiuwei Gao, Padraig Strappe, Zhongkai Zhou
Summary: An animal model of Cd-induced kidney damage was used to investigate the nephroprotective potential of probiotic-fermented Ganoderma lucidum (FGL) through metabonomic analysis. The results showed that FGL enhanced sugar and amino acid metabolism, and the interaction between Ganoderma lucidum and probiotics increased short-chain fatty acid production through gut microbiota fermentation. FGL intervention alleviated Cd-induced nephrotoxicity by increasing antioxidant enzyme activity and reducing pro-inflammatory and apoptotic factors. Transcriptome analysis revealed that FGL intervention improved renal dysfunction by decreasing the expression of genes involved in oxidative stress, inflammatory response, and apoptosis. This study highlights a new approach for achieving positive nephroprotection through natural product intervention.
Article
Food Science & Technology
Lan Yang, Xincong Kang, Wenjing Dong, Lei Wang, Shifeng Liu, Xiaohong Zhong, Dongbo Liu
Summary: The study found that Ganoderma lucidum polysaccharide (GLP) can be utilized by human fecal microbiota, modify microbial community and metabolic function, and potentially serve as a novel prebiotic for human health benefits.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Editorial Material
Multidisciplinary Sciences
Qizheng Wu, Hui Zhong, Yafei Zhai, Yanjiong Jia, Zhinan Yin, Min Chen, Hengwen Yang, Peng George Wang
Letter
Biology
Qizheng Wu, Fang Liu, Yu Song, Qingyun Meng, Xunlian Zhang, Huizi Li, Jingyu Sun, Hongqi Gao, Peng George Wang, Yun Kong, Min Chen
SCIENCE CHINA-LIFE SCIENCES
(2019)
Article
Chemistry, Medicinal
Qizheng Wu, Jinfeng Ye, Yicong Chao, Shuchen Dong, Min Niu, Yaqian Wang, Zhaoxi Liu, Wang Chen, Ningning Ge, Shuhua Lu, Peng George Wang, Min Chen
Summary: A rapid and sensitive chemoenzymatic method has been developed for detecting a specific structure on the surface of pathogens. This method shows potential for diagnosis and therapeutics of pathogenic infections.
ACS INFECTIOUS DISEASES
(2022)
Letter
Dermatology
Qizheng Wu, Panpan Cheng, Tianying Shao, Zhengyu Li, Qingjie Ji, Lina Wang, Shulan Yao, Bin Lu
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)