Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon

Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation

(2021) Tingting Sang et al.   CARBOHYDRATE POLYMERS

Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice

(2020) Sydney Lavoie et al.   GASTROENTEROLOGY

Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism?

(2020) Dominik Ternes et al.   TRENDS IN MICROBIOLOGY

Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects

(2020) Risheng Zhao et al.   GASTROENTEROLOGY

Comparison in bioactivity and characteristics of Ginkgo biloba seed polysaccharides from four extract pathways

(2020) Jialun Hu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Polysaccharide from Pycnoporus sanguineus ameliorates dextran sulfate sodium-induced colitis via helper T cells repertoire modulation and autophagy suppression

(2020) Muxia Li et al.   PHYTOTHERAPY RESEARCH

Colorectal cancer is associated with increased circulating lipopolysaccharide, inflammation and hypercoagulability

(2020) Greta M. de Waal et al.   Scientific Reports

Ganoderma lucidum polysaccharide (GLP) enhances antitumor immune response by regulating differentiation and inhibition of MDSCs via a CARD9-NF-κB-IDO pathway

(2020) Yongyong Wang et al.   BIOSCIENCE REPORTS

Gut Microbiota Manipulation as a Tool for Colorectal Cancer Management: Recent Advances in Its Use for Therapeutic Purposes

(2020) Federica Perillo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer

(2020) Winnie Fong et al.   ONCOGENE

Dietary Supplementation of Foxtail Millet Ameliorates Colitis-Associated Colorectal Cancer in Mice via Activation of Gut Receptors and Suppression of the STAT3 Pathway

(2020) Bowei Zhang et al.   Nutrients

Cancer-protective effect of a synbiotic combination between Lactobacillus gasseri 505 and a Cudrania tricuspidata leaf extract on colitis-associated colorectal cancer

(2020) Nam Su Oh et al.   Gut Microbes

Anemoside B4 prevents acute ulcerative colitis through inhibiting of TLR4/NF-κB/MAPK signaling pathway

(2020) Huimiao Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Holistic View of Berberine Inhibiting Intestinal Carcinogenesis in Conventional Mice Based on Microbiome-Metabolomics Analysis

(2020) Haitao Chen et al.   Frontiers in Immunology

Effects of WSG, a polysaccharide from Ganoderma lucidum, on suppressing cell growth and mobility of lung cancer

(2020) Wei-Hung Hsu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells

(2019) Haider Rasheed Alrafas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Importance of probiotics in the prevention and treatment of colorectal cancer

(2019) Majid Eslami et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Modulation of gut microbiota by Ilex kudingcha improves dextran sulfate sodium-induced colitis

(2019) Peng Wan et al.   FOOD RESEARCH INTERNATIONAL

Inflammation and Inflammatory Cytokine Contribute to the Initiation and Development of Ulcerative Colitis and Its Associated Cancer

(2019) Dianbo Yao et al.   INFLAMMATORY BOWEL DISEASES

Microbiome-metabolomic analysis of the impact of Zizyphus jujuba cv. Muzao polysaccharides consumption on colorectal cancer mice fecal microbiota and metabolites

(2019) Xiaolong Ji et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The gut microbiota and colon cancer

(2019) Wendy S. Garrett   SCIENCE

Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation

(2019) Haitao Pan et al.   Cell Death & Disease

Corrigendum: Anti-breast Cancer Enhancement of a Polysaccharide From Spore of Ganoderma lucidum With Paclitaxel: Suppression on Tumor Metabolism With Gut Microbiota Reshaping

(2019) Jiyan Su et al.   Frontiers in Microbiology

Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

(2019) Sunny H. Wong et al.   Nature Reviews Gastroenterology & Hepatology

Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-α and IL-6 levels and functions and by rebalancing intestinal microbiota

(2019) Chunsaier Wang et al.   BMC MICROBIOLOGY

Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

(2019) Mingyang Song et al.   GASTROENTEROLOGY

Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rats

(2019) Mingyi Chen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Dendrobium officinale polysaccharides alleviate colon tumorigenesis via restoring intestinal barrier function and enhancing anti-tumor immune response

(2019) Jian Liang et al.   PHARMACOLOGICAL RESEARCH

Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and microenvironment in Apc mice

(2019) Imran Khan et al.   PHARMACOLOGICAL RESEARCH

Potential Mechanisms of Probiotics Action in the Prevention and Treatment of Colorectal Cancer

(2019) Marta Molska et al.   Nutrients

Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis

(2019) Yuhua Li et al.   CARBOHYDRATE POLYMERS

Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer

(2019) Atena Soleimani et al.   GENE

Good Gone Bad: One Toxin Away From Disease for Bacteroides fragilis

(2019) Ezequiel Valguarnera et al.   JOURNAL OF MOLECULAR BIOLOGY

Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota

(2019) Minna Wu et al.   PHARMACOLOGICAL RESEARCH

Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer

(2018) Jackie E. Bader et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation

(2018) Lili Chen et al.   CARCINOGENESIS

The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications.

(2018) Sara Daniela Gomes et al.   CURRENT MEDICINAL CHEMISTRY

Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice

(2018) Sean R. Llewellyn et al.   GASTROENTEROLOGY

Falcarindiol inhibits LPS-induced inflammation via attenuating MAPK and JAK-STAT signaling pathways in murine macrophage RAW 264.7 cells

(2018) Thamizhiniyan Venkatesan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice

(2018) Maria Carolina S Mendes et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Ganoderma lucidum Polysaccharides as An Anti-cancer Agent

(2018) Didem Sohretoglu et al.   Anti-Cancer Agents in Medicinal Chemistry

Ganoderma lucidum: Persuasive biologically active constituents and their health endorsement

(2018) Md Faruque Ahmad   BIOMEDICINE & PHARMACOTHERAPY

Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways

(2018) Tao Hu et al.   CARBOHYDRATE POLYMERS

VSL#3 can prevent ulcerative colitis-associated carcinogenesis in mice

(2018) Chun-Sai-Er Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of 17beta;-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model

(2018) Chin-Hee Song et al.   Gut and Liver

Isolation, Structures, and Bioactivities of the Polysaccharides from Gynostemma pentaphyllum (Thunb.) Makino: A Review

(2018) Xiaolong Ji et al.   Biomed Research International

Anti-breast Cancer Enhancement of a Polysaccharide From Spore of Ganoderma lucidum With Paclitaxel: Suppression on Tumor Metabolism With Gut Microbiota Reshaping

(2018) Jiyan Su et al.   Frontiers in Microbiology

Origin, Differentiation, and Function of Intestinal Macrophages

(2018) Calum C. Bain et al.   Frontiers in Immunology

Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice

(2017) Chun Xiao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk

(2017) Derek V. Seidel et al.   SEMINARS IN CANCER BIOLOGY

Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages

(2017) Weishan Fang et al.   Scientific Reports

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Ganoderma

(2016) Nebojša V. Kladar et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Diet, microorganisms and their metabolites and colon cancer

(2016) Stephen J. D. O'Keefe   Nature Reviews Gastroenterology & Hepatology

Lipopolysaccharide increases the release of VEGF-C that enhances cell motility and promotes lymphangiogenesis and lymphatic metastasis through the TLR4- NF-κB/JNK pathways in colorectal cancer

(2016) Guangwei Zhu et al.   Oncotarget

Tissue-Associated Bacterial Alterations in Rectal Carcinoma Patients Revealed by 16S rRNA Community Profiling

(2016) Andrew M. Thomas et al.   Frontiers in Cellular and Infection Microbiology

An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis

(2016) S Sivaprakasam et al.   Oncogenesis

Structure–function relationships of immunostimulatory polysaccharides: A review

(2015) Sónia S. Ferreira et al.   CARBOHYDRATE POLYMERS

Role of polysaccharides in food, digestion, and health

(2015) A. Lovegrove et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Ganoderma lucidum for Cancer Treatment

(2015) Shujie Cheng et al.   INTEGRATIVE CANCER THERAPIES

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

(2015) Isabel C.F.R. Ferreira et al.   PHYTOCHEMISTRY

Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

(2015) Chih-Jung Chang et al.   Nature Communications

Dietary cocoa protects against colitis-associated cancer by activating the Nrf2/Keap1 pathway

(2014) Ashok Kumar Pandurangan et al.   BIOFACTORS

Microbes, Microbiota, and Colon Cancer

(2014) Cynthia L. Sears et al.   Cell Host & Microbe

Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome

(2014) L. Flanagan et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation

(2014) Wei Dou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

Multiple Roles of Toll-Like Receptor 4 in Colorectal Cancer

(2014) Dhanusha Yesudhas et al.   Frontiers in Immunology

Structure of the gut microbiome following colonization with human feces determines colonic tumor burden

(2014) Nielson T Baxter et al.   Microbiome

Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma

(2013) Hui-Min Chen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Colonization of the Human Gut by E. coli and Colorectal Cancer Risk

(2013) M. Bonnet et al.   CLINICAL CANCER RESEARCH

Functional genomic analyses of the gut microbiota for CRC screening

(2013) Sergey R. Konstantinov et al.   Nature Reviews Gastroenterology & Hepatology

Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes

(2013) Shih-Fen Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

iNOS signaling interacts with COX-2 pathway in colonic fibroblasts

(2012) Yingting Zhu et al.   EXPERIMENTAL CELL RESEARCH

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer

(2010) E L Wang et al.   BRITISH JOURNAL OF CANCER

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis

(2010) Masayuki Fukata et al.   INFLAMMATORY BOWEL DISEASES

The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker

(2010) Rosaria Cammarota et al.   Journal of Translational Medicine

Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer

(2009) Linda A. Feagins et al.   Nature Reviews Gastroenterology & Hepatology

Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis

(2008) Harry J. Flint et al.   NATURE REVIEWS MICROBIOLOGY