Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau

Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression

(2017) Meige Zheng et al.   FASEB JOURNAL

Two decades of new drug discovery and development for Alzheimer's disease

(2017) Zhidong Liu et al.   RSC Advances

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

(2016) P Lei et al.   MOLECULAR PSYCHIATRY

Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss

(2016) J. Di et al.   Scientific Reports

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

(2015) Michael Zengerle et al.   ACS Chemical Biology

Development of small molecules targeting the pseudokinase Her3

(2015) Sang Min Lim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

(2015) Jan Krönke et al.   NATURE

Catalytic in vivo protein knockdown by small-molecule PROTACs

(2015) Daniel P Bondeson et al.   Nature Chemical Biology

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

Small-Molecule Control of Intracellular Protein Levels through Modulation of the Ubiquitin Proteasome System

(2014) Dennis L. Buckley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Loss of MAP Function Leads to Hippocampal Synapse Loss and Deficits in the Morris Water Maze with Aging

(2014) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Clearance of the intracellular high level of the Tau protein directed by an artificial synthetic hydrolase

(2014) Ting-Ting Chu et al.   Molecular BioSystems

Motor and cognitive deficits in aged tau knockout mice in two background strains

(2014) Peng Lei et al.   Molecular Neurodegeneration

Pharmacological targeting of the pseudokinase Her3

(2014) Ting Xie et al.   Nature Chemical Biology

Targeted protein destabilization reveals an estrogen-mediated ER stress response

(2014) Kanak Raina et al.   Nature Chemical Biology

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs

(2013) J. Hines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitor Mediated Protein Degradation

(2012) Marcus J.C. Long et al.   CHEMISTRY & BIOLOGY

Greasy tags for protein removal

(2012) Taavi K. Neklesa et al.   NATURE

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells

(2012) A. J. Holland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins

(2011) Taavi K Neklesa et al.   Nature Chemical Biology

Autophagic degradation of tau in primary neurons and its enhancement by trehalose

(2011) Ulrike Krüger et al.   NEUROBIOLOGY OF AGING

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

(2008) Ashley R. Schneekloth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sequestration of Copper from β-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents

(2008) Wei-hui Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CSF biomarker levels in early and late onset Alzheimer's disease

(2008) Femke H. Bouwman et al.   NEUROBIOLOGY OF AGING