C-7 modified flavonoids as novel tyrosyl-tRNA synthetase inhibitors

Translation quality control is critical for bacterial responses to amino acid stress

(2016) Tammy J. Bullwinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates

(2015) Qinggang Mei et al.   Beilstein Journal of Organic Chemistry

Adenosine analogs as inhibitors of tyrosyl-tRNA synthetase: Design, synthesis and antibacterial evaluation

(2015) Wei Wei et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and structure–activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS)

(2015) John D. Williams et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel Daidzein Analogs and Theirin VitroAnti-Influenza Activities

(2015) Shu-Ting Chung et al.   CHEMISTRY & BIODIVERSITY

Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold

(2015) Zhu-Ping Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Modification of MTT Assay for Precision and Repeatability and Its Mechanistic Implication

(2014) Xu-Dong Wang et al.   ASIAN JOURNAL OF CHEMISTRY

Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: Design, synthesis and evaluation as antibacterial agent

(2014) Xu-Dong Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Flavones: An important scaffold for medicinal chemistry

(2014) Manjinder Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dissociation Constants and Solubilities of Daidzein and Genistein in Different Solvents

(2014) Guanjun Nan et al.   JOURNAL OF CHEMICAL AND ENGINEERING DATA

First Identification of Boronic Species as Novel Potential Inhibitors of the Staphylococcus aureus NorA Efflux Pump

(2014) Fanny Fontaine et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region

(2014) Sameer P. Kawatkar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines

(2014) Thanh Lam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Characterization of Potent Thiazoles versus Methicillin- and Vancomycin-Resistant Staphylococcus aureus

(2014) Haroon Mohammad et al.   JOURNAL OF MEDICINAL CHEMISTRY

3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: Synthesis, molecular docking and antibacterial evaluation

(2013) Xu-Dong Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-based design of flavone-based inhibitors of wild-type and T315I mutant of ABL

(2013) Hyeonjeong Choe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hispidulin Induces Apoptosis Through Mitochondrial Dysfunction and Inhibition of P13k/Akt Signalling Pathway in HepG2 Cancer Cells

(2013) Hui Gao et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Involvement of UDP-glucuronosyltranferases and sulfotransferases in the liver and intestinal first-pass metabolism of seven flavones in C57 mice and humans in vitro

(2012) Lan Tang et al.   FOOD AND CHEMICAL TOXICOLOGY

Chemistry of biologically important flavones

(2012) Alok K. Verma et al.   TETRAHEDRON

Synthesis, structure, molecular docking, and structure–activity relationship analysis of enamines: 3-Aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials

(2011) Zhu-Ping Xiao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

(E)-2-Benzylidenebenzocyclanones, part VIII: spectrophotometric determination of pK a values of some natural and synthetic chalcones and their cyclic analogues

(2011) Ivan Kron et al.   MONATSHEFTE FUR CHEMIE

Antioxidant Activity of the Dihydrochalcones Aspalathin and Nothofagin and Their Corresponding Flavones in Relation to Other Rooibos (Aspalathus linearis) Flavonoids, Epigallocatechin Gallate, and Trolox

(2009) Petra W. Snijman et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antioxidant evaluation of O-methylated metabolites of catechin, epicatechin and quercetin

(2009) Montserrat Dueñas et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Lavendamycin Antitumor Agents: Structure-Based Design, Synthesis, and NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Model Validation with Molecular Docking and Biological Studies

(2008) Mary Hassani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aminoacyl tRNA synthetases and their connections to disease

(2008) S. G. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and Evaluation of Derrubone and Select Analogues

(2007) Jedidiah M. Hastings et al.   JOURNAL OF ORGANIC CHEMISTRY