期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 73, 期 2, 页码 369-373出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo702366g
关键词
-
资金
- NCI NIH HHS [R01 CA120458, R01 CA114393] Funding Source: Medline
[GRAPHICS] Recently, we reported that the natural product derrubone exhibits Hsp90 inhibitory activity. Due to its unique architectural scaffold and proposed rapid assembly, the synthesis of this natural product was pursued with the aim of identifying structure-activity relationships. Synthesis of the natural product was accomplished in eight highly convergent steps, which led to a facile method for the construction of related compounds. Biological evaluation of derrubone and its analogues identified several compounds that exhibit low micromolar inhibitory activity against breast and colon cancer cell lines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据