Bis-isoquinolinium and bis-pyridinium acetylcholinesterase inhibitors: in vitro screening of probes for novel selective insecticides

Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

(2015) Eugenie Nepovimova et al.   JOURNAL OF MEDICINAL CHEMISTRY

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment

(2015) Jan Korabecny et al.   MOLECULES

Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae

(2015) James M. Mutunga et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Molecular Dynamics, Monte Carlo Simulations, and Langevin Dynamics: A Computational Review

(2015) Eric Paquet et al.   Biomed Research International

Preparation of 7-Methoxy Tacrine Dimer Analogs and TheirIn vitro/In silicoEvaluation as Potential Cholinesterase Inhibitors

(2015) Sang Kwang Lee et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines

(2015) Avi Ring et al.   PLoS One

7-MEOTA–donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies

(2014) Jan Korabecny et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mosquitocidal carbamates with low toxicity to agricultural pests: an advantageous property for insecticide resistance management

(2014) Daniel R Swale et al.   PEST MANAGEMENT SCIENCE

A Resurrection of 7-MEOTA: A Comparison with Tacrine

(2013) Ondrej Soukup et al.   Current Alzheimer Research

Comparison of Novel Tacrine and 7-MEOTA Derivatives with Aromatic and Alicyclic Residues: Synthesis, Biological Evaluation and Docking Studies

(2013) Jan Korabecny et al.   LETTERS IN ORGANIC CHEMISTRY

Evaluation of novel carbamate insecticides for neurotoxicity to non-target species

(2013) Ying Jiang et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase

(2012) Joshua A. Hartsel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel and Viable Acetylcholinesterase Target Site for Developing Effective and Environmentally Safe Insecticides

(2012) Yuan-Ping Pang et al.   CURRENT DRUG TARGETS

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum

(2012) Yanhui Lu et al.   Scientific Reports

Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors—implications for early Myasthenia gravis treatment

(2011) Marketa Komloova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular dynamics simulations and drug discovery

(2011) Jacob D Durrant et al.   BMC BIOLOGY

The preparation,in vitroscreening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage

(2011) Kamil Musilek et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage—initial study for Myasthenia gravis implications

(2010) Kamil Musilek et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies

(2010) Kamil Musilek et al.   ChemMedChem

Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage – Implications for early Myasthenia gravis treatment

(2010) Kamil Musilek et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Functional analysis and molecular characterization of two acetylcholinesterases from the German cockroach,Blattella germanica

(2010) Y. H. Kim et al.   INSECT MOLECULAR BIOLOGY

Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX

(2010) Miroslav Pohanka et al.   TALANTA

Selective and Irreversible Inhibitors of Aphid Acetylcholinesterases: Steps Toward Human-Safe Insecticides

(2009) Yuan-Ping Pang et al.   PLoS One

Evidence of multiple pyrethroid resistance mechanisms in the malaria vector Anopheles gambiae sensu stricto from Nigeria

(2008) T.S. Awolola et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE