Novel anti-tubulin agents from plant and marine origins: insight from a molecular modeling and dynamics study

Natural antitubulin agents: Importance of 3,4,5-trimethoxyphenyl fragment

(2015) Arvind S. Negi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agents

(2015) Ram C. Mishra et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent

(2015) Tejashree Mahaddalkar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular dynamics simulation of hydrated d(CGGGTACCCG)4as a four-way DNA Holliday junction and comparison with the crystallographic structure

(2015) Ramesh Kumar Yadav et al.   MOLECULAR SIMULATION

Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A

(2014) Andrea E. Prota et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of other microtubule-stabilizer families

(2014) Cynthia F. Brogdon et al.   ANTI-CANCER DRUGS

Podoverine A—a novel microtubule destabilizing natural product from the Podophyllum species

(2014) Tuyen Thi Ngoc Tran et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments

(2014) Cassandra D. M. Churchill et al.   Chemical Biology & Drug Design

Stabilization of Microtubules by Taxane Diterpenoids: Insight from Docking and MD simulations

(2014) Umesh Yadava et al.   JOURNAL OF BIOLOGICAL PHYSICS

Structural insight into epothilones antitumor activity based on the conformational preferences and tubulin binding modes of epothilones A and B obtained from molecular dynamics simulations

(2014) Verónica A. Jiménez et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The Binding Sites of Microtubule-Stabilizing Agents

(2013) Jessica J. Field et al.   CHEMISTRY & BIOLOGY

Pyrazolo[3,4-d]pyrimidines as inhibitor of anti-coagulation and inflammation activities of phospholipase A 2 : insight from molecular docking studies

(2013) Umesh Yadava et al.   JOURNAL OF BIOLOGICAL PHYSICS

Similarity-based virtual screening for microtubule stabilizers reveals novel antimitotic scaffold

(2013) Ahmed T. Ayoub et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

(2013) A. E. Prota et al.   SCIENCE

Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy

(2012) Hiroaki Yajima et al.   JOURNAL OF CELL BIOLOGY

Discovery of Novel Tubulin Inhibitors via Structure-Based Hierarchical Virtual Screening

(2012) Ran Cao et al.   Journal of Chemical Information and Modeling

Insights into the Interaction of Discodermolide and Docetaxel with Tubulin. Mapping the Binding Sites of Microtubule-Stabilizing Agents by Using an Integrated NMR and Computational Approach

(2011) Angeles Canales et al.   ACS Chemical Biology

Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel Site

(2011) Enrique Calvo et al.   BIOCHEMISTRY

A comparison of crystallographic and DFT optimized geometries on two taxane diterpenoids and docking studies with phospholipase A2

(2011) Umesh Yadava et al.   MEDICINAL CHEMISTRY RESEARCH

Advances in therapy: eribulin improves survival for metastatic breast cancer

(2010) Patrick G. Morris   ANTI-CANCER DRUGS

Randomized Phase III Trial of Ixabepilone Plus Capecitabine Versus Capecitabine in Patients With Metastatic Breast Cancer Previously Treated With an Anthracycline and a Taxane

(2010) Joseph A. Sparano et al.   JOURNAL OF CLINICAL ONCOLOGY

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

Cevipabulin (TTI-237): Preclinical and clinical results for a novel antimicrotubule agent

(2009) S. Ayral-Kaloustian et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

The Anti-Cancer Activity of Noscapine: A Review

(2009) Massoud Mahmoudian et al.   Recent Patents on Anti-Cancer Drug Discovery

Indibulin, a Novel Microtubule Inhibitor, Discriminates between Mature Neuronal and Nonneuronal Tubulin

(2008) A. Wienecke et al.   CANCER RESEARCH

The Bound Conformation of Microtubule-Stabilizing Agents: NMR Insights into the Bioactive 3D Structure of Discodermolide and Dictyostatin

(2008) Angeles Canales et al.   CHEMISTRY-A EUROPEAN JOURNAL