Article
Chemistry, Multidisciplinary
Heerak Chugh, Pramod Kumar, Neeraj Kumar, Rajesh K. Gaur, Gagan Dhawan, Ramesh Chandra
Summary: In this study, the binding of Noscapine with human hemoglobin was investigated using various experimental methods, which showed a feasible interaction and formation of a binding complex between the two molecules. This interaction led to a change in the secondary structure of Hb and was further verified to be stable at the molecular level through docking studies.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Niloofar Savadkouhi, Peyman Salehi, Houri Sepehri, Ladan Delphi, Hasan Rafati
Summary: In this study, PEGylated derivatives of noscapine with enhanced solubility were synthesized and their anticancer activities were evaluated. The results showed that increasing the PEG chain length improved the water solubility and cytotoxicity of the derivatives. These new PEGylated compounds may have the potential to be developed as novel anticancer drugs.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Ewa Trybus, Teodora Krol, Wojciech Trybus
Summary: The study investigates the mechanisms of action of azelastine hydrochloride in cancer treatment. The results demonstrate that azelastine can induce degradation processes, increase autophagy activity, and activate apoptosis, leading to anti-proliferative, cytotoxic, autophagic, and apoptotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wojciech Trybus, Ewa Trybus, Teodora Krol
Summary: This study evaluated the effects of combining emodin with vinblastine on cervical cancer cells. The combination increased oxidative stress, mitotic catastrophe, and apoptosis, potentially offering a promising approach for anticancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Faezeh Nemati, Iris Bischoff-Kont, Peyman Salehi, Samad Nejad-Ebrahimi, Maryam Mohebbi, Morteza Bararjanian, Nasim Hadian, Zahra Hassanpour, Yvonne Jung, Sofie Schaerlaekens, Daniel Lucena-Agell, Maria A. Oliva, Robert Fuerst, Hamid R. Nasiri
Summary: A library of novel noscapine derivatives was synthesized, with two of them identified as potent inhibitors of MDA-MB-231 breast cancer cells. These derivatives have improved antiproliferative properties compared to the lead compound noscapine.
BIOORGANIC CHEMISTRY
(2021)
Article
Oncology
Aysha Alneyadi, Zohra Nausheen Nizami, Hanan E. E. Aburawi, Soleiman Hisaindee, Muhammad Nawaz, Samir Attoub, Gaber Ramadan, Nehla Benhalilou, Mazoun Al Azzani, Yassine Elmahi, Aysha Almeqbali, Khalid Muhammad, Ali H. H. Eid, Ranjit Vijayan, Rabah Iratni
Summary: This study synthesized two new chromene compounds and tested their activity against hormone-responsive and TNBC cells. The compounds specifically inhibited the proliferation of TNBC cells and disrupted the polymerization of microtubules within the cytoskeleton. Additionally, the compounds efficiently blocked TNBC migration and inhibited the formation of blood vessels. These findings highlight the therapeutic potential of these compounds against TNBC.
Article
Chemistry, Medicinal
Praveen Kumar Reddy Nagireddy, Dinesh Kumar, Vamsi Krishna Kommalapati, Ravi Kumar Pedapati, Venkateswarlu Kojja, Anjana Devi Tangutur, Srinivas Kantevari
Summary: Noscapine is a phthalide isoquinoline alkaloid with potent antitumor activity, and novel analogs of noscapine have been synthesized with one compound (9-ethynyl noscapine) showing significant anticancer activity against cervical cancer cells (HeLa) by disrupting tubulin polymerization, cell cycle progression, and inducing apoptosis.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Chemistry, Medicinal
Cassandra Yong, Shane M. Devine, Anne-Catherine Abel, Stefan D. Tomlins, Divya Muthiah, Xuexin Gao, Richard Callaghan, Michel O. Steinmetz, Andrea E. Prota, Ben Capuano, Peter J. Scammells
Summary: Extensive research has been conducted over the past two decades to discover noscapine derivatives with improved potency. This study focused on modifications to the 1,3-benzodioxole moiety of noscapine analogues, resulting in the discovery of potent cytotoxic agents against various types of cancer. Additionally, X-ray crystallography studies provided insight into the interactions between these noscapinoids and tubulin, which will aid in the development of future noscapine derivatives with enhanced properties.
Article
Integrative & Complementary Medicine
Hassan El-Abid, Cristina Amaral, Sara C. Cunha, Georgina Correia-da-Silva, Jose Fernandes, Mohieddine Moumni, Nattercia Teixeira
Summary: This study investigated the hydroethanolic extracts of Juniperus oxycedrus L., a common Mediterranean tree, and found that they have anti-cancer and antioxidant properties in ER+ breast cancer cells, suggesting their potential therapeutic role as an adjunct treatment for this type of cancer.
JOURNAL OF HERBAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Shuang Zhao, Yufei Tang, Ruohan Wang, Masoud Najafi
Summary: This article focuses on the cell death mechanisms induced by paclitaxel, a chemotherapy drug, in cancer treatment and the resistance of cancer cells to paclitaxel. The study found that paclitaxel can induce apoptosis and mitotic catastrophe, as well as other cell death mechanisms, and it can also lead to drug resistance. The article also discusses the use of combination therapies to overcome drug resistance.
Article
Multidisciplinary Sciences
Mojtaba Golpich, Elham Amini, Amirhosein Kefayat, Mehrafarin Fesharaki, Jamal Moshtaghian
Summary: This study evaluated the anti-cancer effects of hibernating common carp plasma on 4T1 cancer cells, showing significant reduction in cell viability, morphology changes, migration inhibition, induction of apoptosis and cell cycle arrest at the G2/M phase, as well as decreased tumor volume and weight, reduced metastatic colonies in the lungs and liver, increased survival time, and decreased cell proliferation in the tumor section. Alpha-2-macroglobulin in hibernating fish plasma was found to be significantly increased, suggesting it as a potential novel cancer treatment strategy.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Vijay Laxmi Trivedi, Ruchi Soni, Praveen Dhyani, Priyanka Sati, Silvia Tejada, Antoni Sureda, William N. Setzer, Ahmad Faizal Abdull Razis, Babagana Modu, Monica Butnariu, Javad Sharifi-Rad
Summary: With the development of highly effective plant-based medications, the use of phytomedicines against complex diseases like cancer is increasing. This review focuses on the traits, roles, and mechanisms of the pentacyclic triterpenes known as boswellic acids (BAs) and their semi-synthetic derivatives in treating certain cancers. The review also explores the sources of BAs, their conservation, and the potential of biotechnology in improving BA production.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xiao Fu, Mu Li, Cuilian Tang, Zezhi Huang, Masoud Najafi
Summary: Increasing apoptosis, mitotic catastrophe, senescence, and necrosis can help overcome tumor resistance to therapy. Stimulation of autophagy cell death may also be useful for cancer therapy. Resveratrol has potential to affect various signaling pathways related to cell death and modulate cancer cell death mechanisms.
Article
Biochemistry & Molecular Biology
Minghuan Gao, Yuying Yang, Ying Gao, Tong Liu, Qi Guan, Tianhao Zhou, Yani Shi, Mingjing Hao, Zengqiang Li, Daiying Zuo, Weige Zhang, Yingliang Wu
Summary: This study demonstrates that the hyperactive glycolysis plays a crucial role in maintaining cell viability and drug resistance in multidrug-resistant cancer cells. A newly synthesized tubulin inhibitor, YAN, can inhibit glycolysis and disrupt the apoptosis resistance-related protein localization, enhancing the effectiveness of chemotherapy. In addition, the glycolysis inhibitor 2-DG can synergistically enhance YAN-induced cell apoptosis. These findings provide important insights into the development of new drugs for multidrug-resistant cancer and offer a potential solution for mitotic slippage-mediated drug resistance.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Oncology
Cindy Wavelet-Vermuse, Olena Odnokoz, Yifan Xue, Xinghua Lu, Massimo Cristofanilli, Yong Wan
Summary: CDC20 functions as a critical cell cycle regulator and plays an important role in cancer development and drug resistance. This study reveals that CDC20 interacts with hnRNPU and regulates its ubiquitination, which influences chromatin organization and drug resistance in breast cancer cells. These findings provide new insights into the role of the CDC20-hnRNPU axis in regulating chromatin organization and drug resistance, suggesting its potential as a target for cancer therapy.
Article
Chemistry, Analytical
Zahra Kiani, Massoumeh Shafiei, Parvaneh Rahimi-Moghaddam, Ali Asghar Karkhane, Soltan Ahmed Ebrahimi
ANALYTICA CHIMICA ACTA
(2012)
Article
Biochemical Research Methods
Michael F. Lin, Irwin Jungreis, Manolis Kellis
Article
Pharmacology & Pharmacy
Fatemeh Namvaran, Negar Azarpira, Parvaneh Rahimi-Moghaddam, Mohammad Hossein Dabbaghmanesh
EUROPEAN JOURNAL OF PHARMACOLOGY
(2011)
Article
Genetics & Heredity
Fatemeh Namvaran, Negar Azarpira, Bita Geramizadeh, Parvaneh Rahimi-Moghaddam
Article
Biochemistry & Molecular Biology
Fatemeh Namvaran, Parvaneh Rahimi-Moghaddam, Negar Azarpira, Saman Nikeghbalian
MOLECULAR BIOLOGY REPORTS
(2012)
Article
Biochemistry & Molecular Biology
Fatemeh Namvaran, Parvaneh Rahimi-Moghaddam, Negar Azarpira, Mohammad Hosein Dabbaghmanesh
MOLECULAR BIOLOGY REPORTS
(2012)
Article
Genetics & Heredity
Nazila Alinaghian, Elaheh Abdollahi, Mansour Torab, Maral Khodaparast, Farhad Zamani, Parvaneh Rahimi-Moghaddam
Correction
Genetics & Heredity
Nazila Alinaghian, Elaheh Abdollahi, Mansour Torab, Maral Khodaparast, Farhad Zamani, Parvaneh Rahimi-Moghaddam
Article
Biochemistry & Molecular Biology
Elham Ghorbani, Mahsa Mohammadi, Seyed Kazem Malakouti, Hamed Mohammadi-Kangarani, Elaheh Abdollahi, Mansour Torab, Parvaneh Rahimi-Moghaddam
Summary: The deregulation of the renin-angiotensin system (RAS) is believed to play a significant role in suicide, with the ACE gene insertion/deletion (I/D) polymorphism potentially influencing the risk. The study in an Iranian population found a significant association between the DD genotype of ACE I/D polymorphism and suicide attempts, with a potential link to the severity of depression symptoms.
BIOCHEMICAL GENETICS
(2021)
Article
Integrative & Complementary Medicine
Foad Ghazizadeh, Massoumeh Shafiei, Reza Falak, Mahshid Panahi, Naser Rakhshani, Soltan Ahmed Ebrahimi, Parvaneh Rahimi-Moghaddam
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Review
Health Care Sciences & Services
Valentina A. Babenko, Ksenia S. Fedulova, Denis N. Silachev, Parvaneh Rahimi-Moghaddam, Yulia N. Kalyuzhnaya, Svetlana V. Demyanenko, Egor Y. Plotnikov
Summary: Ischemic stroke is a major cause of disability and death worldwide. Thrombolytic therapy with tissue plasminogen activator (tPA) is the only approved treatment, but it often causes hemorrhagic transformation (HT). The activity and expression of matrix metalloproteinases (MMPs) in brain tissue play a crucial role in HT development.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Marjan Emzhik, Parvaneh Rahimi-Moghaddam, Soltan Ahmad Ebrahimi, Fariborz Keyhanfar, Ashraf Sadat Moazzam
INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
(2015)
Article
Medicine, General & Internal
Fatemeh Namvaran, Parvaneh Rahimi-Moghaddam, Negar Azarpira, Mohammad Hossein Dabbaghmanesh, Marzieh Bakhshayeshkaram, Mohamad Mahdi Namvaran
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2013)
Article
Medicine, General & Internal
Parvaneh Rahimi-Moghaddam, Soltan Ahmad Ebrahimi, Hourmazd Ourmazdi, Monavvar Selseleh, Maryam Karjalian, Giti Haj-Hassani, Mohammad Hossein Alimohammadian, Massoud Mahmoudian, Massoumeh Shafiei
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2011)
Article
Medicine, General & Internal
Fatemeh Namvaran, Parvaneh Rahimi-Moghaddam, Negar Azarpira
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2011)
