Article
Biochemistry & Molecular Biology
Aleksandra Yu Egorshina, Alexey Zamaraev, Vitaliy O. Kaminskyy, Tatiana Radygina, Boris Zhivotovsky, Gelina S. Kopeina
Summary: Mitotic catastrophe is a defensive mechanism that promotes elimination of cells with aberrant mitosis by triggering cell death pathways. In certain conditions, mitotic catastrophe can precede necroptosis in addition to apoptosis and autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ewa Trybus, Teodora Krol, Wojciech Trybus
Summary: The study investigates the mechanisms of action of azelastine hydrochloride in cancer treatment. The results demonstrate that azelastine can induce degradation processes, increase autophagy activity, and activate apoptosis, leading to anti-proliferative, cytotoxic, autophagic, and apoptotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Aleksei Parshenkov, Thierry Hennet
Summary: Altered surface glycosylation is a major characteristic of tumor cells and can be recognized by lectins, which can distinguish tumor cells from healthy cells based on the expression of glycosylation-dependent markers. Lectins induce cell death through various pathways, and their broad cytotoxic response makes them potential candidates for therapies targeting tumor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Haoran Chen, Zhongyu Han, Qian Luo, Yi Wang, Qiju Li, Lisui Zhou, Houdong Zuo
Summary: Cancer has always been a global issue, and radiotherapy has significantly improved the survival rate of cancer patients. Understanding the mechanisms by which radiotherapy induces different cell death modes can greatly enhance the efficiency of cancer radiotherapy.
RADIATION ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Can Yang, Zhen Zhang, Jieting Liu, Peijian Chen, Jialing Li, Haiying Shu, Yanhui Chu, Luxin Li
Summary: This paper discusses the pathologic research and drug therapy of diabetic kidney disease (DKD), focusing on the death processes and mechanisms of glomerular podocytes in DKD. The complexity and potential crosstalk between various modes of cell death are also examined, providing insights into podocyte death and laying the foundation for future targeted therapy strategies for DKD treatment.
MOLECULAR MEDICINE
(2023)
Review
Pathology
Esra Bozgeyik, Ibrahim Bozgeyik
Summary: Cell death was traditionally classified into two types, necrosis and apoptosis. However, recent studies have identified new cell death pathways that are distinct from necrosis and apoptosis. The development of natural-based anticancer drugs that target these non-canonical cell death mechanisms is of great interest due to the resistance and adverse effects associated with apoptosis-targeting drugs in cancer therapy.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Valentina Giansante, Gianmarco Stati, Silvia Sancilio, Emanuela Guerra, Saverio Alberti, Roberta Di Pietro, Joerg D. Hoheisel
Summary: Pancreatic cancer is the seventh leading cause of cancer-related death, and its incidence is increasing each year. The low relative survival rate and challenges of heterogeneity and tumor microenvironment in pancreatic cancer have emphasized the need for novel therapeutic strategies. This review focuses on the role of necroptosis in pancreatic cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Javier Fernandez-Diaz, Roberto Beteta-Goebel, Manuel Torres, Joan Cabot, Paula Fernandez-Garcia, Victoria Llado, Pablo V. Escriba, Xavier Busquets
Summary: This study investigated the activity of a synthetic lipid, TGM4, on pancreatic cancer cells and found that it inhibited cell proliferation and induced cell death through the activation of cytocidal autophagy. These findings highlight the importance of lipid signaling in cancer and suggest synthetic lipid structures as potential approaches to treat pancreatic cancer and other neoplasias.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ganesh Pai Bellare, Birija Sankar Patro
Summary: This study proposes the usage of resveratrol as a chemosensitizer in combination with talazoparib for targeting HR proficient breast cancers. Resveratrol effectively enhances talazoparib-induced cell death in breast cancer cells and shows minimal cytotoxicity in normal cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Oncology
Rui Qin, Feng-Ming You, Qian Zhao, Xin Xie, Cheng Peng, Gu Zhan, Bo Han
Summary: This review systematically summarizes the anticancer effects of indole alkaloids by targeting different regulated cell death (RCD) subroutines, and discusses the cross talk between different subroutines mediated by indole alkaloids and the combined strategies. The information provided in this review is important for the design of novel molecules and the development of new strategies for cancer therapy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alessio Malacrida, Roberta Rigolio, Luigi Celio, Silvia Damian, Guido Cavaletti, Vincenzo Mazzaferro, Mariarosaria Miloso
Summary: Cholangiocarcinoma is the most common cancer of the biliary tract, and surgical resection is currently the only potentially curative option with low survival rates. Research shows that Rigosertib may be a potential therapeutic option for nonresectable patients with cholangiocarcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Weiwei Zhao, Qing Wang, Le Li, Chengshen Xie, Yequn Wu, Mayank Gautam, Lijia Li
Summary: This study discovers that SIRT1 may be involved in regulating mitotic catastrophe (MC) through autophagy and BubR1 signaling. Overexpression of SIRT1 alleviates MC, while its knockdown exacerbates this phenomenon. In addition, the regulation of autophagy and BubR1 signaling also affects MC. These results provide evidence for SIRT1, autophagy, and BubR1 as potential therapeutic targets for cancer.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jonathan D. Humphries, Junzhe Zha, Jessica Burns, Janet A. Askari, Christopher R. Below, Megan R. Chastney, Matthew C. Jones, Aleksandr Mironov, David Knight, Derek A. O'Reilly, Mark J. Dunne, David R. Garrod, Claus Jorgensen, Martin J. Humphries
Summary: PDAC has a dismal prognosis due to its aggressive progression, late detection, and lack of druggable driver mutations. This study reveals that hemidesmosome-mediated adhesion may be more important than classical focal adhesion in PDAC. In addition, both HPDE cells and human PDAC organoids exhibit the formation of hemidesmosomes.
Review
Oncology
Tarak Chouari, Francesca Soraya La Costa, Nabeel Merali, Maria-Danae Jessel, Shivan Sivakumar, Nicola Annels, Adam E. Frampton
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a challenging cancer to treat due to late detection, lack of effective screening tests, and resistance to standard treatments. Immunotherapy has emerged as a potential solution, stimulating the immune system to fight cancer cells. This paper summarizes studies on immunotherapies in PDAC, discusses their limitations, and explores avenues for future research.
Article
Biochemistry & Molecular Biology
Charlotte Dubois, Kateryna Kondratska, Artem Kondratskyi, Angela Morabito, Lina Mesilmany, Valerio Farfariello, Robert-Alain Toillon, Nathalie Ziental Gelus, Emilie Laurenge, Fabien Vanden Abeele, Loic Lemonnier, Natalia Prevarskaya
Summary: Changes in cytosolic free Ca2+ concentration play a central role in cellular processes. ORAI3 channels are expressed in both normal and pancreatic ductal adenocarcinoma cell lines, affecting store-operated calcium entry (SOCE). Silencing ORAI3 increases SOCE in PDAC cell lines and decreases SOCE in normal pancreatic cell line, impacting proliferation, cell cycle, viability, mitotic catastrophe, and cell death.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Cell Biology
Ewelina Barcinska, Justyna Wierzbicka, Agata Zauszkiewicz-Pawlak, Dagmara Jacewicz, Aleksandra Dabrowska, Iwona Inkielewicz-Stepniak
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Crystallography
Anton Gradisek, Mario Cifelli, Michal Wojcik, Tomaz Apih, Sergey Dvinskikh, Ewa Gorecka, Valentina Domenici
Article
Chemistry, Multidisciplinary
Ewelina Tomczyk, Aleksander Prominski, Maciej Baginski, Ewa Gorecka, Michal Wojcik
Article
Chemistry, Multidisciplinary
Piotr Lesiak, Karolina Bednarska, Wiktor Lewandowski, Michal Wojcik, Sylwia Polakiewicz, Maciej Baginski, Tomasz Osuch, Konrad Markowski, Kamil Orzechowski, Michal Makowski, Jan Bolek, Tomasz R. Wolinski
Article
Nanoscience & Nanotechnology
Justyna Hajtuch, Nadhim Hante, Ewelina Tomczyk, Michal Wojcik, Marek Witold Radomski, Maria Jose Santos-Martinez, Iwona Inkielewicz-Stepniak
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Chemistry, Multidisciplinary
Maciej Baginski, Martyna Tupikowska, Guillermo Gonzalez-Rubio, Michal Wojcik, Wiktor Lewandowski
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Syou-P'heng Do, Amine Missaoui, Alessandro Coati, Delphine Coursault, Haifa Jeridi, Andrea Resta, Nicolas Goubet, Michal M. Wojcik, Arnaud Choux, Sebastien Royer, Emrick Briand, Bertrand Donnio, Jean Louis Gallani, Brigitte Pansu, Emmanuel Lhuillier, Yves Garreau, David Babonneau, Michel Goldmann, Doru Constantin, Bruno Gallas, Bernard Croset, Emmanuelle Lacaze
Article
Chemistry, Physical
Aleksander Prominski, Ewelina Tomczyk, Mateusz Pawlak, Agnieszka Jedrych, Jozef Mieczkowski, Wiktor Lewandowski, Michal Wojcik
Article
Physics, Multidisciplinary
A. Grempka, M. Wojcik, B. Pietka, J. Szczytko
ACTA PHYSICA POLONICA A
(2020)
Article
Pharmacology & Pharmacy
Justyna Hajtuch, Maria Jose Santos-Martinez, Michal Wojcik, Ewelina Tomczyk, Maciej Jaskiewicz, Wojciech Kamysz, Magdalena Narajczyk, Iwona Inkielewicz-Stepniak
Summary: This study compared the antibacterial properties and potential cytotoxic effects of commercially available uncoated silver nanoparticles (AgNPs) with lipoic acid coated silver nanoparticles (AgNPsLA). The results showed that AgNPsLA had better antimicrobial activity and biosafety profile compared to uncoated AgNPs. This has important implications for the potential application of AgNPsLA in medical devices.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kamil Orzechowski, Martyna Tupikowska, Olga Strzezysz, Ting-Mao Feng, Wei-Yuan Chen, Liang-Ying Wu, Chun-Ta Wang, Eva Oton, Michal M. Wojcik, Maciej Baginski, Piotr Lesiak, Wiktor Lewandowski, Tomasz R. Wolinski
Summary: It has been demonstrated that small achiral gold nanoparticles (Au NPs) decorated with liquid crystal-like ligands can enhance the chiral twist and thermal stability of blue phase liquid crystals (BPLCs). The functionalization of Au NPs plays a critical role in the phase sequence of BPLCs.
Article
Chemistry, Multidisciplinary
Agnieszka Jedrych, Mateusz Pawlak, Ewa Gorecka, Wiktor Lewandowski, Michal Maksymilian Wojcik
Summary: We have demonstrated the fabrication of dual-responsive (thermo/light) chiral plasmonic films by using photoswitchable achiral liquid crystal (LCs) for templating helical assemblies of Au NPs. The chiroptical properties of the organic and inorganic components were confirmed by circular dichroism spectroscopy (CD), with a dissymmetry factor (g-factor) of up to 0.2. The controlled melting of organic nanotubes and/or inorganic nanohelices can be achieved by exposing the material to UV light and can be reversed using visible light, with the chiroptical response further modified by varying the temperature.
Article
Chemistry, Multidisciplinary
Zuzanna Z. Janczuk, Agnieszka Jedrych, Sylwia Parzyszek, Anita Gardias, Jacek Szczytko, Michal Wojcik, Paola Tiberto
Summary: This study reports the preparation of MNPs composites using excess liquid crystal-like ligands, which allows for precise and reversible control of magnetic nanoparticles in thin films, showing great potential for various applications.
Article
Physics, Fluids & Plasmas
Piotr Fronczak, Agata Fronczak, Piotr Lesiak, Karolina Bednarska, Wiktor Lewandowski, Michal Wojcik
Summary: This article demonstrates the application of elementary cellular automata in optical systems to understand the mechanisms behind the formation of periodic patterns in nanoparticle-doped liquid crystals. The simplified model provides an explanation for the observed linear relationship between periodicity and system size.
Article
Medicine, General & Internal
Karol P. Steckiewicz, Ewelina Barcinska, Katarzyna Sobczak, Ewelina Tomczyk, Michal Wojcik, Iwona Inkielewicz-Stepniak
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2020)