Unveiling the therapeutic potential of natural-based anticancer compounds inducing non-canonical cell death mechanisms

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines

(2022) Yuru Zhou et al.   CANCER BIOLOGY & THERAPY

Apigenin ameliorates di(2-ethylhexyl) phthalate-induced ferroptosis: The activation of glutathione peroxidase 4 and suppression of iron intake

(2022) Dongxu Han et al.   FOOD AND CHEMICAL TOXICOLOGY

Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells

(2022) Valeria Consoli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin improves the function of umbilical vein endothelial cells by inhibiting H2O2‑induced pyroptosis

(2022) Yulin Yuan et al.   Molecular Medicine Reports

Alpinumisoflavone Disrupts Endoplasmic Reticulum and Mitochondria Leading to Apoptosis in Human Ovarian Cancer

(2022) Taeyeon Hong et al.   Pharmaceutics

The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death

(2022) Diego Luis Ribeiro et al.   Pharmaceutics

Dihydroartemisinin Triggers Ferroptosis in Multidrug-Resistant Leukemia Cells

(2022) Xueyan Zhang et al.   DNA AND CELL BIOLOGY

Dihydroartemisinin inhibits the growth of pancreatic cells by inducing ferroptosis and activating antitumor immunity

(2022) Hongbo Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated paraptosis accompanied by autophagosome accumulation

(2022) Hao Zheng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis

(2022) Hailong Gong et al.   Oxidative Medicine and Cellular Longevity

Glabridin induces paraptosis-like cell death via ER stress in breast cancer cells

(2022) Xiang Cui et al.   Heliyon

Tanshinone IIA: A Review of its Anticancer Effects

(2021) Zhong‐ying Fang et al.   Frontiers in Pharmacology

Curcumin induces ferroptosis in non‐small‐cell lung cancer via activating autophagy

(2021) Xin Tang et al.   Thoracic Cancer

Nobiletin promotes the pyroptosis of breast cancer via regulation of miR ‐200b/ JAZF1 axis

(2021) Ji‐Guo Wang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Tanshinone IIA regulates microRNA‑125b/foxp3/caspase‑1 signaling and inhibits cell viability of nasopharyngeal carcinoma

(2021) Youhu Wang et al.   Molecular Medicine Reports

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

(2021) Madhuri Shende Warkad et al.   Scientific Reports

Curcumin Targets Both Apoptosis and Necroptosis in Acidity-Tolerant Prostate Carcinoma Cells

(2021) Yoon-Jin Lee et al.   Biomed Research International

Curcumin reverses the sunitinib resistance in clear cell renal cell carcinoma (ccRCC) through the induction of ferroptosis via the ADAMTS18 gene

(2021) Ben Xu et al.   Translational Cancer Research

Dioscin: A review on pharmacological properties and therapeutic values

(2021) Shinjini Bandopadhyay et al.   BIOFACTORS

Aglycone flavonoid brachydin A shows selective cytotoxicity and antitumoral activity in human metastatic prostate (DU145) cancer cells

(2021) Larissa Cristina Bastos de Oliveira et al.   CYTOTECHNOLOGY

Ultrastructural changes in giant cell tumor of bone cultured cells exposed to quercetin

(2021) Eréndira Estrada-Villaseñor et al.   ULTRASTRUCTURAL PATHOLOGY

Casticin elicits inflammasome-induced pyroptosis through activating PKR/JNK/NF-κB signal in 5-8F cells

(2020) Chenyan Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Anti-cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis

(2020) Khatereh Khorsandi et al.   Cancer Cell International

Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells

(2020) Rongjun Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds

(2020) Fabrizio Fontana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Tanshinone II A enhances pyroptosis and represses cell proliferation of HeLa cells by regulating miR-145/GSDMD signaling pathway

(2020) Wenjuan Tong et al.   BIOSCIENCE REPORTS

Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis

(2020) Chenwen Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Artemisinin and its derivatives: a promising cancer therapy

(2020) Bushra Hafeez Kiani et al.   MOLECULAR BIOLOGY REPORTS

Isorhamnetin induces the paraptotic cell death through ROS and the ERK/MAPK pathway in OSCC cells

(2020) Qian Chen et al.   ORAL DISEASES

Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes

(2020) Dan Li et al.   Nutrients

Quercetin Induces p53‐independent Cancer Cell Death via TFEB‐mediated Lysosome Activation and ROS‐dependent Ferroptosis

(2020) Zi‐Xuan Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells

(2020) Aveen N. Adham et al.   PHYTOMEDICINE

Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities

(2019) Huaran Zhang et al.   NATURAL PRODUCT RESEARCH

Monocarbonyl curcumin analog A2 potently inhibits angiogenesis by inducing ROS-dependent endothelial cell death

(2019) Bin Liu et al.   ACTA PHARMACOLOGICA SINICA

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

(2019) Guo-Qing Chen et al.   CELL DEATH AND DIFFERENTIATION

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death

(2019) Melania Guerrero-Hue et al.   FASEB JOURNAL

The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

(2019) Abu Hazafa et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Nobiletin and Derivatives: Functional Compounds from Citrus Fruit Peel for Colon Cancer Chemoprevention

(2019) Goh et al.   Cancers

Dioscin inhibits the growth of human osteosarcoma by inducing G2/M‐phase arrest, apoptosis, and GSDME‐dependent cell death in vitro and in vivo

(2019) Qiuyue Ding et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

(2019) Yan Zu et al.   Journal of Orthopaedic Surgery and Research

Gallic Acid Triggers Iron-Dependent Cell Death with Apoptotic, Ferroptotic, and Necroptotic Features

(2019) Ho Man Tang et al.   Toxins

The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma

(2019) Yang Kong et al.   Frontiers in Oncology

Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma

(2019) Ning Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

(2019) Tzu-Chi Chen et al.   Redox Biology

Non-apoptotic cell death in malignant tumor cells and natural compounds

(2018) Jing Ye et al.   CANCER LETTERS

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer

(2018) Jing Xue et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Glabridin induces apoptosis and cell cycle arrest in oral cancer cells through the JNK1/2 signaling pathway

(2018) Chang-Tai Chen et al.   ENVIRONMENTAL TOXICOLOGY

Eupatilin: a natural pharmacologically active flavone compound with its wide range applications

(2018) Bushra Nageen et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Phenolic antioxidants of Morus nigra roots, and antitumor potential of morusin

(2018) Zoofishan Zoofishan et al.   PHYTOCHEMISTRY REVIEWS

Paraptosis in human glioblastoma cell line induced by curcumin

(2018) Monika Garrido-Armas et al.   TOXICOLOGY IN VITRO

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages

(2018) Lan H. Chu et al.   Nature Communications

Anthocyanin is Involved in the Activation of Pyroptosis in Oral Squamous Cell Carcinoma

(2018) Er Yue et al.   PHYTOMEDICINE

Alpinumisoflavone causes DNA damage in Colorectal Cancer Cells via blocking DNA repair mediated by RAD51

(2018) Dong Li et al.   LIFE SCIENCES

Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells

(2018) Xi Chen et al.   Redox Biology

Ferroptosis: bug or feature?

(2017) Scott J. Dixon   IMMUNOLOGICAL REVIEWS

The Role of Resveratrol in Cancer Therapy

(2017) Jeong-Hyeon Ko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway

(2017) Xiangquan Mi et al.   Oncotarget

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phytonutrients Differentially Stimulate NAD(P)H:Quinone Oxidoreductase, Inhibit Proliferation, and Trigger Mitotic Catastrophe in Hepa1c1c7 Cells

(2016) Steven J.T. Jackson et al.   JOURNAL OF MEDICINAL FOOD

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Paraptosis in the anti-cancer arsenal of natural products

(2016) Dongjoo Lee et al.   PHARMACOLOGY & THERAPEUTICS

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression

(2016) Hsin-Lin Cheng et al.   Oncotarget

Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma

(2016) Qun Chu et al.   Oncotarget

Icariin Enhances Cytotoxicity of Doxorubicin in Human Multidrug-Resistant Osteosarcoma Cells by Inhibition of ABCB1 and Down-Regulation of the PI3K/Akt Pathway

(2015) Zhendong Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Fruit and vegetables and cancer risk: a review of southern European studies

(2015) Federica Turati et al.   BRITISH JOURNAL OF NUTRITION

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

(2015) Paul J. Baker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mitochondrial Dysfunction and Ca2+Overload Contributes to Hesperidin Induced Paraptosis in Hepatoblastoma Cells, HepG2

(2015) Silvia Yumnam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Glabridin inhibits cancer stem cell-like properties of human breast cancer cells: An epigenetic regulation of miR-148a/SMAd2 signaling

(2015) Fei Jiang et al.   MOLECULAR CARCINOGENESIS

Pharmacological Profile of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus)

(2015) Ming Liu et al.   MOLECULES

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Glabridin arrests cell cycle and inhibits proliferation of hepatocellular carcinoma by suppressing braf/MEK signaling pathway

(2015) Ziyou Wang et al.   TUMOR BIOLOGY

Icariin Enhances Radiosensitivity of Colorectal Cancer Cells by Suppressing NF-κB Activity

(2014) Yi Zhang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Die another way – non-apoptotic mechanisms of cell death

(2014) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Dimeric Flavonoids from Arrabidaea brachypoda and Assessment of Their Anti-Trypanosoma cruzi Activity

(2014) Cláudia Quintino da Rocha et al.   JOURNAL OF NATURAL PRODUCTS

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Berberine, an Epiphany Against Cancer

(2014) Luis Guamán Ortiz et al.   MOLECULES

Role of the ERK Pathway for Oxidant-Induced Parthanatos in Human Lymphocytes

(2014) Ali A. Akhiani et al.   PLoS One

Hesperidin Induces Paraptosis Like Cell Death in Hepatoblatoma, HepG2 Cells: Involvement of ERK1/2 MAPK

(2014) Silvia Yumnam et al.   PLoS One

Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin

(2014) M J Yoon et al.   Cell Death & Disease

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Chemopreventive Activity of Plant Flavonoid Isorhamnetin in Colorectal Cancer Is Mediated by Oncogenic Src and  -Catenin

(2013) S. M. Saud et al.   CANCER RESEARCH

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

The Cdk inhibitor flavopiridol enhances temozolomide-induced cytotoxicity in human glioma cells

(2013) Takuro Hayashi et al.   JOURNAL OF NEURO-ONCOLOGY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells

(2013) Ming-Der Shi et al.   PHYTOMEDICINE

Simultaneous mitochondrial Ca2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells

(2012) Mi Jin Yoon et al.   CANCER LETTERS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone

(2011) António Pedro Gonçalves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Alpinumisoflavone Induces Apoptosis and Suppresses Extracellular Signal-Regulated Kinases/Mitogen Activated Protein Kinase and Nuclear Factor-κB Pathways in Lung Tumor Cells

(2011) Sim Namkoong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Eupatilin, a dietary flavonoid, induces G2/M cell cycle arrest in human endometrial cancer cells

(2011) Jung-Hoon Cho et al.   FOOD AND CHEMICAL TOXICOLOGY

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action

(2011) David Vauzour et al.   Nutrients

Mitochondrial and Nuclear Cross Talk in Cell Death

(2010) Shaida A. Andrabi et al.   Annals of the New York Academy of Sciences

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

(2010) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos

(2010) Ilio Vitale et al.   EMBO JOURNAL

Icariin exterts negative effects on human gastric cancer cell invasion and migration by vasodilator-stimulated phosphoprotein via Rac1 pathway

(2010) Yongping Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anthocyanins: Natural Colorants with Health-Promoting Properties

(2010) Jian He et al.   Annual Review of Food Science and Technology

Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

(2009) Jayaraj Ravindran et al.   AAPS Journal

Casticin induces leukemic cell death through apoptosis and mitotic catastrophe

(2009) Jia-Kun Shen et al.   ANNALS OF HEMATOLOGY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells

(2009) Mi Jin Yoon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parthanatos, a messenger of death

(2009) Karen Kate David   Frontiers in Bioscience-Landmark

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Programmed Cell Death Pathways and Current Antitumor Targets

(2009) Mei Lan Tan et al.   PHARMACEUTICAL RESEARCH

Molecular Mechanisms of Paraptosis Induction: Implications for a Non-Genetically Modified Tumor Vaccine

(2009) Neil Hoa et al.   PLoS One

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice

(2008) Sattu Kamaraj et al.   INVESTIGATIONAL NEW DRUGS

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

(2008) Sonia Ramos   MOLECULAR NUTRITION & FOOD RESEARCH