Article
Biochemistry & Molecular Biology
Jiaqi Zhu, Peter Langer, Claas Ulrich, Juergen Eberle
Summary: This study investigated the efficacy of three indirubin derivatives in four cSCC cell lines, showing significant effects on cell proliferation, viability, and apoptosis. The mechanisms of action involved induction of reactive oxygen species and activation of various apoptotic pathways, highlighting the importance of ROS in antitumor effects of indirubins.
Review
Biochemistry & Molecular Biology
Gaetana Napolitano, Gianluca Fasciolo, Paola Venditti
Summary: Mitochondria in aerobic eukaryotic cells not only produce energy but also harmful substances such as ROS, and possess an efficient antioxidant system to detoxify these substances. As ROS production increases, mitochondria are damaged and release more harmful substances, but their antioxidant system can detoxify exogenous ROS at the expense of reducing the equivalents generated in mitochondria.
Article
Fisheries
Lunjian Chen, Gen Kaneko, Yichao Li, Jun Xie, Guangjun Wang, Zhifei Li, Jingjing Tian, Kai Zhang, Wangbao Gong, Yun Xia, Ermeng Yu
Summary: The study found that natural oxidant faba beans can improve the muscle textural quality of grass carp, but dietary antioxidants supplementation almost completely abolishes this effect. However, the addition of oxidant (vitamin K3) to commercial feed can effectively improve the muscle textural quality of grass carp. There is a positive feedback relationship between ROS accumulation and production mainly in the mitochondria, which plays a role in improving muscle texture.
Review
Biochemistry & Molecular Biology
Silvia Piccirillo, Simona Magi, Alessandra Preziuso, Tiziano Serfilippi, Giorgia Cerqueni, Monia Orciani, Salvatore Amoroso, Vincenzo Lariccia
Summary: ROS have dual roles, acting as signaling molecules shaping physiological cell functions and as detrimental end products of unbalanced redox reactions. The brain is particularly vulnerable to ROS-mediated toxicity, which may influence the onset and progression of neurodegenerative diseases.
Article
Engineering, Environmental
Javaid Akhter Bhat, Parvaiz Ahmad, Francisco J. Corpas
Summary: Arsenic is toxic to plants and poses severe health risks to humans. Under arsenic stress, endogenous NO metabolism is affected, but exogenous NO application can provide beneficial effects.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Oncology
Osama Hussein Bekhet, Mohamed Elsayed Eid
Summary: This study focused on the roles of reactive oxygen species (ROS) and antioxidants in cancer progression and therapy. Cancer is a diverse disease at the cellular level with different causes. High levels of ROS have protumorigenic activities, while antioxidants play a role in maintaining cellular redox balance.
TRANSLATIONAL CANCER RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon, Dayeh Kim, K. M. K. Swamy, Juyoung Yoon
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Jiaxue Liu, Boyan Jia, Zhibo Li, Wenliang Li
Summary: Applying reactive polymer materials sensitive to biological stimuli has attracted extensive research interest. The application of reactive oxygen species (ROS)-responsive polymers as drug-delivery systems in organisms has received much attention due to the special physiological effects of ROS on tumors or inflammation. The research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed in this paper. From the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels, the future development trends in this field were discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shivkanya Fuloria, Vetriselvan Subramaniyan, Sundram Karupiah, Usha Kumari, Kathiresan Sathasivam, Dhanalekshmi Unnikrishnan Meenakshi, Yuan Seng Wu, Mahendran Sekar, Nitin Chitranshi, Rishabha Malviya, Kalvatala Sudhakar, Sakshi Bajaj, Neeraj Kumar Fuloria
Summary: Evidence suggests that reactive oxygen species (ROS) play complex roles in cancer, with both beneficial and harmful effects, depending on concentration. Further research is needed to understand the relationship between ROS, antioxidants, and cancer, and to develop more accurate methods for ROS detection.
Review
Engineering, Environmental
Faisal Zulfiqar, Muhammad Ashraf
Summary: Arsenic is a highly toxic contaminant in the environment that adversely affects plant growth. Exposure to arsenic can cause oxidative stress, disrupting normal plant functions. Plants have natural defense mechanisms and antioxidants to counteract arsenic stress.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xiaoluan Lu, Zhongshan He, Xiao Xiao, Xuelian Wei, Xiangrong Song, Shiyong Zhang
Summary: A new natural antioxidant-based nanodrug (VC@cLAVs) has been developed to treat atherosclerosis (AS) by loading antioxidants vitamin C (VC) into lipoic acid (LA)-constructed vesicles. This nanodrug not only increases the blood half-life of natural antioxidants but also enhances the antioxidation capacity through the mutual recycling of two redox pairs LA/DHLA and VC/DHA. In vivo results show that VC@cLAVs significantly reduces plaque area in mice compared to free VC and LA. This natural antioxidant-based nanodrug holds great potential for clinical applications.
Review
Chemistry, Multidisciplinary
Gabriel T. Huynh, Vidhishri Kesarwani, Julia A. Walker, Jessica E. Frith, Laurence Meagher, Simon R. Corrie
Summary: The combination of nanomaterials and fluorescent detection offers new opportunities for monitoring oxygen and ROS in biological systems, improving optical properties and interactions with cells and media, and providing ratiometric sensing robust to environmental drift.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Patryk Szymaszek, Patrycja Sroda, Malgorzata Tyszka-Czochara, Anna Chachaj-Brekiesz, Tomasz Swiergosz, Joanna Ortyl
Summary: Here we report the synthesis of a novel fluorescent probe P182 for quantitative measurement of H2O2. This fluorometric probe displays a fluorescence turn-on response in the presence of H2O2. It offers good performances in terms of sensitivity and response time, and shows non-toxic activity for in vivo studies. This study provides research on molecular fluorescence probe for the detection of H2O2.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Article
Oncology
Hiroshi Y. Yamada, Yuting Zhang, Arun Reddy, Altaf Mohammed, Stan Lightfoot, Wei Dai, Chinthalapally V. Rao
Article
Biochemistry & Molecular Biology
Chinthalapally V. Rao, Saira Sanghera, Yuting Zhang, Laura Biddick, Arun Reddy, Stan Lightfoot, Wei Dai, Hiroshi Y. Yamada
MOLECULAR CARCINOGENESIS
(2016)
Article
Oncology
Chinthalapally V. Rao, Saira Sanghera, Yuting Zhang, Laura Biddick, Arun Reddy, Stan Lightfoot, Naveena B. Janakiram, Altaf Mohammed, Wei Dai, Hiroshi Y. Yamada
Review
Oncology
Chinthalapally V. Rao, Adam S. Asch, Hiroshi Y. Yamada
Article
Biochemistry & Molecular Biology
Chinthalapally V. Rao, Adam S. Asch, Hiroshi Y. Yamada
MOLECULAR CARCINOGENESIS
(2017)
Article
Oncology
H. Y. Yamada, G. Kumar, Y. Zhang, E. Rubin, S. Lightfoot, W. Dai, C. V. Rao
Article
Cell Biology
Chinthalapally V. Rao, Mudassir Farooqui, Yuting Zhang, Adam S. Asch, Hiroshi Y. Yamada
Article
Cell Biology
Chinthalapally V. Rao, Mudassir Farooqui, Adam S. Asch, Hiroshi Y. Yamada
Review
Cell Biology
Chinthalapally V. Rao, Adam S. Asch, Daniel J. J. Carr, Hiroshi Y. Yamada
Article
Cell Biology
Chinthalapally Rao, Mudassir Farooqui, Avanish Madhavaram, Yuting Zhang, Adam S. Asch, Hiroshi Y. Yamada
Article
Oncology
Chinthalapally V. Rao, Chao Xu, Mudassir Farooqui, Yuting Zhang, Adam S. Asch, Hiroshi Y. Yamada
Summary: Genomic instability plays a crucial role in the evolution and treatment of lung adenocarcinoma, with genes associated with survival potentially serving as future therapeutic targets. The immune system has been identified as a key player in suppressing genomic instability and cancer development in the lungs, suggesting potential avenues for chemotherapy, chemoprevention, and immunomodulation approaches.
Article
Multidisciplinary Sciences
Chinthalapally V. V. Rao, Chao Xu, Yuting Zhang, Adam S. S. Asch, Hiroshi Y. Y. Yamada
Summary: This study identified specific genes associated with genomic instability in colorectal cancer, providing new insights and targets for the development of therapeutic approaches.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Hiroshi Y. Yamada, Chinthalapally V. Rao
Summary: The PRECEDE Consortium was launched internationally to evaluate the surveillance of high-risk individuals (HRI) of pancreatic cancer, focusing on genetic risk factors. During the early recruitment period from May 2020 to March 2022, data on 1,113 HRIs were collected. In this Cancer Prevention Research article, Katona and colleagues reported the demographics of the participants, revealing significant disparities in gender, race, and ethnicity. The PRECEDE Consortium now aims to address these disparities and increase the representation of underrepresented groups in the next 3 years.
CANCER PREVENTION RESEARCH
(2023)
Article
Oncology
Hiroshi Y. Yamada, Chao Xu, Kenneth L. Jones, Philip H. O'Neill, Madka Venkateshwar, Srikanth Chiliveru, Hyung-Gyoon Kim, Mark Doescher, Katherine T. Morris, Upender Manne, Chinthalapally V. V. Rao
Summary: The majority of cancer samples analyzed in the US are from white people, resulting in biases in racial and ethnic treatment outcomes. Colorectal cancer rates are higher among African Americans in Alabama and American Indians in Oklahoma. Differences in transcriptomic profiles between racial groups may contribute to these disparities. The expression levels of certain genes and pathways differ significantly in CRCs of African Americans and American Indians compared to white individuals. Targeting strategies designed for white CRC patients may be less effective for these racial groups. These findings highlight the need for optimized interventions to address racial disparities in CRC treatment.
NPJ PRECISION ONCOLOGY
(2023)