Review
Nutrition & Dietetics
Fardowsa Abdi, Saania Zuberi, Jedid-Jah Blom, David Armstrong, Maria Ines Pinto-Sanchez
Summary: A gluten-free diet is essential for treating celiac disease and may improve symptoms in non-celiac gluten/wheat sensitivity. However, adopting a gluten-free diet or a gluten-restricted diet may increase the risk of malnutrition and nutrient deficiencies. Therefore, patients with these conditions should undergo nutritional assessment and monitoring, and receive multidisciplinary care for long-term nutrition management.
Article
Gastroenterology & Hepatology
Pavan Dhoble, Philip Abraham, Devendra Desai, Anand Joshi, Tarun Gupta, Shachish Doctor, Anand Deshpande, Rajeshwari Basavanna
Summary: In a region in India where mixed-cereal diets are common, 11% of patients with IBS self-reported wheat sensitivity, with none having positive celiac serology. Most patients showed symptomatic improvement on a wheat-free diet.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Nutrition & Dietetics
Valentina Ponzo, Ilario Ferrocino, Ilaria Goitre, Marianna Pellegrini, Mauro Bruno, Marco Astegiano, Gianni Cadario, Eleonora Castellana, Fabio Bioletto, Maria Rita Corvaglia, Patrizia Malfa, Luca Cocolin, Ezio Ghigo, Simona Bo
Summary: By conducting a double-blind placebo-controlled gluten challenge test, this study found that almost half of individuals suspected of gluten sensitivity reported symptoms even with the placebo. These individuals showed lower mental health scores, increased risk for eating disorders, and a different gut microbiota composition compared to placebo-responsive participants.
Review
Food Science & Technology
Laryssa Rosa de Sousa Franckilin, Anna Clara Paiva Menezes Dos Santos, Flavio Eduardo Dias Araujo Freitas, Isabela Garbazza Vieira, Carlos Eduardo de Freitas Jorge, Daniela Godoy Neri, Maria Vitoria Cota de Abreu, Janaina Koenen Fonseca, Renato Guimaraes Loffi, Giselle Foureaux
Summary: Gluten, the most common protein in wheat, is associated with celiac disease, wheat allergy, and non-celiac gluten sensitivity. These disorders have similar clinical manifestations but differ in development pathways and diagnostic criteria. A gluten-free diet is the most effective treatment for celiac disease and may also lead to improvements in neuropathologies and the gut microbiome.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Nutrition & Dietetics
Andrea Costantino, Gloria Maria Aversano, Giovanni Lasagni, Veronica Smania, Luisa Doneda, Maurizio Vecchi, Leda Roncoroni, Elide Anna Pastorello, Luca Elli
Summary: Many patients experience symptoms after wheat ingestion, which could be due to celiac disease, wheat allergy, or non-celiac wheat sensitivity. This review provides an algorithm for diagnosing the cause of symptoms and emphasizes the importance of a personalized approach and regular follow-up.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Multidisciplinary
Susana Sanchez-Leon, Carmen Haro, Myriam Villatoro, Luis Vaquero, Isabel Comino, Ana B. Gonzalez-Amigo, Santiago Vivas, Jorge Pastor, Carolina Sousa, Blanca B. Landa, Francisco Barro
Summary: The study found that gastrointestinal symptoms of NCWS patients did not significantly change between gluten-free bread and tritordeum bread. Participants rated tritordeum bread higher than gluten-free bread in terms of acceptability. Analysis of the gut microbiota showed that tritordeum consumption does not alter the global structure and composition of the intestinal microbiota.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Review
Food Science & Technology
Kalekristos Yohannes Woldemariam, Juanli Yuan, Zhen Wan, Qinglin Yu, Yating Cao, Huijia Mao, Yingli Liu, Jing Wang, Hongyan Li, Baoguo Sun
Summary: Wheat mainly consists of gluten with 30% gliadin and 50% glutenin, which are associated with celiac disease. The challenge lies in discovering new gluten-based peptides with high affinity toward T-cells. The highly immunogenic 33-mer gliadin peptide is considered the main cause, so consistent data on different gluten peptides and their immunogenicity is urgently needed.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Noe Ontiveros, Raul Emilio Real-Delor, Jose Antonio Mora-Melgem, Carlos Eduardo Beltran-Cardenas, Oscar Gerardo Figueroa-Salcido, Marcela de Jesus Vergara-Jimenez, Feliznando Isidro Cardenas-Torres, Lilian Karem Flores-Mendoza, Jesus Gilberto Aramburo-Galvez, Francisco Cabrera-Chavez
Summary: The study found that a significant number of Paraguayan adults suffer from gluten-related disorders, with a higher prevalence among women than men. Most individuals adhering to a gluten-free diet do so based on recommendations from healthcare professionals.
Review
Gastroenterology & Hepatology
Benjamin Lebwohl, Alberto Rubio-Tapia
Summary: The incidence of celiac disease is increasing due to both improved recognition and a real increase of the disorder. The reasons for this true rise are unclear, but may be related to environmental factors. Early-life gluten exposure is a major focus of prevention efforts.
Review
Food Science & Technology
Carolina Sabenca, Miguel Ribeiro, Telma de Sousa, Patricia Poeta, Ana Sofia Bagulho, Gilberto Igrejas
Summary: Wheat has become one of the most important cereals in the human diet in the last 10,000 years, providing energy as well as essential nutrients. However, the gluten in wheat can trigger immune-mediated diseases such as celiac disease, leading to an increasing number of people adhering to gluten-free diets without medical necessity.
Article
Nutrition & Dietetics
Stephanie M. Moleski, Apeksha Shah, Philip Durney, Michael Matthews, Gagan Kaushal, Colin Smith, Katelyn C. Koons, Emily Rubin, Patrick Casey, Robin Miller, Cynthia Miller, Mahreema Jawairia, Ahmed Hasan, Anthony J. DiMarino
Summary: The study found that there was no significant difference in symptom severity within the NCGS group whether they received placebo or gluten. Patients with NCGS were more adherent to the GFD based on stool and urine GIP results, and had increased symptom severity at baseline compared with healthy controls. Neither group had significantly increased symptoms after ingestion of gluten.
Article
Gastroenterology & Hepatology
Rachel U. Lee, Shauna L. Stahlman, Jared S. Magee
Summary: This article describes the epidemiology of celiac disease in the US military population. A population-based study was conducted using data from 2000 to 2021, revealing an increasing trend in incidence and prevalence rates.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Nutrition & Dietetics
Julia Zimmermann, Friedrich H. Longin, Anna Schweinlin, Maryam Basrai, Stephan C. Bischoff
Summary: Individuals suspected of non-celiac wheat sensitivity often report better tolerance of spelt compared to wheat bakery products. However, this study found no difference in tolerance between wheat and spelt bread, suggesting a strong nocebo effect for wheat and a placebo effect for spelt.
Review
Medicine, General & Internal
Feliznando Isidro Cardenas-Torres, Francisco Cabrera-Chavez, Oscar Gerardo Figueroa-Salcido, Noe Ontiveros
Summary: Non-celiac gluten sensitivity (NCGS) is a clinical entity characterized by symptomatic responses to gluten-containing foods without celiac disease or wheat allergy. Diagnosis requires gluten challenges, while treatment involves dietary restrictions of potential triggers. Further research is needed to understand NCGS pathogenesis and the effectiveness of dietary interventions.
MEDICINA-LITHUANIA
(2021)
Article
Multidisciplinary Sciences
Daniel R. Monaco, Brandon M. Sie, Thomas R. Nirschl, Audrey C. Knight, Hugh A. Sampson, Anna Nowak-Wegrzyn, Robert A. Wood, Robert G. Hamilton, Pamela A. Frischmeyer-Guerrerio, H. Benjamin Larman
Summary: Allergic reactions occur when IgE molecules are crosslinked by antigens. The AllerScan system identifies differences between wheat allergy and sensitivity, as well as a key wheat epitope that triggers dominant IgE responses in allergic patients.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Pasquale Mansueto, Maurizio Soresi, Giuseppina Candore, Chiara Garlisi, Francesca Fayer, Caterina Maria Gambino, Francesco La Blasca, Aurelio Seidita, Alberto D'Alcamo, Bruna Lo Sasso, Ada Maria Florena, Girolamo Geraci, Giacomo Caio, Umberto Volta, Roberto De Giorgio, Marcello Ciaccio, Antonio Carroccio
Summary: The study found that approximately one in four patients with NCWS had autoimmune diseases, with a high positivity rate for autoimmune antibodies, suggesting a potential association between NCWS and autoimmune diseases.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Letter
Gastroenterology & Hepatology
Jamie Zhen, Juan Pablo Stefanolo, Maria de la Paz Temprano, Sebastian Tedesco, Caroline Seiler, Alberto Fernandez Caminero, Enrique de-Madaria, Miguel Montoro Huguet, Santiago Vivas, Sonia Isabel Niveloni, Premysl Bercik, Edgardo Smecuol, Luis Uscanga, Elena Trucco, Virginia Lopez, Carolina Olano, Pasquale Mansueto, Antonio Carroccio, Peter H. R. Green, Andrew Day, Jason Tye-Din, Julio Cesar Bai, Carolina Ciacci, Elena F. Verdu, Benjamin Lebwohl, Maria Ines Pinto-Sanchez
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jamie Zhen, Juan Pablo Stefanolo, Maria de la Paz Temprano, Caroline L. Seiler, Alberto Caminero, Enrique De-Madaria, Miguel Montoro Huguet, Vivas Santiago, Sonia Isabel Niveloni, Edgardo Gustavo Smecuol, Luis Uzcanga Dominguez, Elena Trucco, Virginia Lopez, Carolina Olano, Pasquale Mansueto, Antonio Carroccio, Peter H. Green, Donald Duerksen, Andrew S. Day, Jason A. Tye-Din, Julio Cesar Bai, Carolina Ciacci, Elena F. Verdu, Benjamin Lebwohl, M. Ines Pinto-Sanchez
Summary: The survey found that over half of celiac disease patients perceive themselves to be at a higher risk of contracting COVID-19 compared to the general population, resulting in some taking additional precautions. Older age, male gender, and strict adherence to a gluten-free diet were associated with lower risk perception, while patients with comorbidities tended to perceive a higher risk.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Pasquale Mansueto, Maurizio Soresi, Sergio Peralta, Simona Perricone, Francesco La Blasca, Roberto Sichera, Ornella Giambalvo, Antonio Carroccio
Summary: The study revealed a high frequency of self-reported wheat sensitivity (SRWS) in outpatients referred for digestive endoscopy, with a lack of medical accuracy in identifying possible gluten-related diseases.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Antonio Carroccio, Maurizio Soresi, Marta Chiavetta, Francesco La Blasca, Stella Compagnoni, Alessandra Giuliano, Francesca Fayer, Francesca Mandreucci, Daniele Castellucci, Aurelio Seidita, Andrea Affronti, Ada Maria Florena, Pasquale Mansueto
Summary: NCWS patients commonly present with IBS-like symptoms, with around 50% also experiencing neuropsychiatric manifestations. They exhibit a longer duration of symptoms and a higher frequency of positive serum anti-nuclear antibodies. These findings suggest the importance of investigating a correlation between symptoms and wheat ingestion in patients with IBS-like and neuropsychiatric manifestations of unknown cause to identify potential NCWS patients with atypical symptoms.
Article
Gastroenterology & Hepatology
Antonio Carroccio, Giuseppe Celano, Carmelo Cottone, Giuseppe Di Sclafani, Lucia Vannini, Alberto D'Alcamo, Mirco Vacca, Francesco Maria Calabrese, Pasquale Mansueto, Maurizio Soresi, Ruggiero Francavilla, Maria De Angelis
Summary: The study found that a diet containing a mix of ancient wheat varieties can significantly improve hematochemical parameters and increase the gut microbiota’s ability to metabolize carbohydrates. Additionally, several volatile organic compounds increased after a period of consuming a diet enriched with ancient grain products.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Pasquale Mansueto, Gabriele Spagnuolo, Silvia Calderone, Carmela Cinzia D'Agate, Salvatore Cosenza, Giuseppe Leonardi, Salvatore Camilleri, Mirco Pistone, Giovanna Seminara, Carlo Alaimo, Maurizio Soresi, Antonio Carroccio, Serena Garufi
Summary: This study retrospectively evaluated the data of 369 patients with CD from the Sicilian Network and found that non-classical CD presentation was more common, there was a diagnostic delay of approximately 9 years, most patients did not undergo multiple duodenal biopsies, and 59.9% of the patients received unrecommended CD serology assays.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Nutrition & Dietetics
Antonio Carroccio, Maurizio Soresi, Beatrice Mantia, Francesca Fayer, Francesco La Blasca, Aurelio Seidita, Alberto D'Alcamo, Ada Maria Florena, Chiara Tine, Chiara Garlisi, Pasquale Mansueto
Summary: The study found that only 56% of SRMI patients were lactose maldigesters and intolerant at LHBT; 68% of SRMI patients were also suffering from IBS; 74% of the patients reported dyspepsia, and weight loss was recorded in 20% of SRMI patients. In the prospective study, 86% of patients experienced symptoms during the DBPC cow's milk challenge.
Review
Nutrition & Dietetics
Pasquale Mansueto, Aurelio Seidita, Marta Chiavetta, Dario Genovese, Alessandra Giuliano, Walter Priano, Antonio Carroccio, Alessandra Casuccio, Emanuele Amodio
Summary: This narrative review analyzed the correlation between diet and clinical outcomes of familial Mediterranean fever (FMF). Conflicting results were found regarding the association between high-fat and high-salt food intake and FMF attack recurrence. Wheat was suggested to potentially play a role in FMF. A diet rich in antioxidants and anti-inflammatory supplements may partly reduce symptoms and improve the well-being of FMF patients. However, further studies are needed to clarify the impact of diet on FMF symptom triggering.
Article
Medicine, General & Internal
Aurelio Seidita, Pasquale Mansueto, Alessandra Giuliano, Marta Chiavetta, Francesca Mandreucci, Maurizio Soresi, Mattia Pistone, Stella Compagnoni, Daniele Castellucci, Gianluca Bisso, Francesco Faraci, Salvatore Maestri, Rosaria Disclafani, Anna Sapone, Alessio Fasano, Antonio Carroccio
Summary: This observational study found that Non-celiac Wheat Sensitivity (NCWS) patients who consume ancient grains may have a delayed diagnosis due to the clinical benefit (tolerability) obtained with these grains. Even after diagnosis, some patients continue to consume ancient grains and have mild or no symptoms.
FRONTIERS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Aurelio Seidita, Pasquale Mansueto, Stella Compagnoni, Daniele Castellucci, Maurizio Soresi, Giorgio Chiarello, Giorgia Cavallo, Gabriele De Carlo, Alessia Nigro, Marta Chiavetta, Francesca Mandreucci, Alessandra Giuliano, Rosaria Disclafani, Antonio Carroccio
Summary: This study assessed the frequency, severity, morphologic features, and pathogenic factors of anemia in patients with Celiac Disease (CD) and found that iron deficiency anemia (IDA) is common, especially in women. The study also showed that some women with CD continue to have IDA despite following a strict gluten-free diet, and low body mass index and menstrual abnormalities might contribute to the persistence of anemia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nutrition & Dietetics
Aurelio Seidita, Pasquale Mansueto, Alessandra Giuliano, Marta Chiavetta, Maurizio Soresi, Antonio Carroccio
Summary: Inflammatory/allergic conditions should be considered in self-reported milk intolerance patients who test negative and/or are asymptomatic at Lactose Hydrogen Breath Test. Fecal calprotectin values were analyzed in these patients and suggest the existence of an allergic/inflammatory pathogenetic mechanism in a subset of self-reported milk intolerance subjects. Fecal calprotectin results are in keeping with this hypothesis, but cannot differentiate lactose tolerant from intolerant patients.
Article
Geriatrics & Gerontology
Francesco Saverio Ragusa, Luisa Solimando, Caterina Mandala, Roberta Masnata, Gregorio Ciulla, Stefano Ciriminna, Francesco La Blasca, Pasquale Mansueto, Nicola Veronese, Mario Barbagallo
Summary: The study found a positive association between higher multidimensional prognostic index (MPI) values, indicating frailty, and the prevalence of infectious diseases, including multidrug-resistant pathogens, resulting in increased antibiotic costs.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
M. Pistone, A. Seidita, P. Mansueto, M. Soresi, F. La Blasca, L. Giannitrapani, A. Carroccio
DIGESTIVE AND LIVER DISEASE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
A. Seidita, P. Mansueto, M. Soresi, G. Chiarello, F. La Blasca, L. Giannitrapani, A. Carroccio
DIGESTIVE AND LIVER DISEASE
(2022)