Article
Medicine, Research & Experimental
Luigi Barrea, Marianna Donnarumma, Sara Cacciapuoti, Giovanna Muscogiuri, Ludovica De Gregorio, Chiara Blasio, Silvia Savastano, Annamaria Colao, Gabriella Fabbrocini
Summary: This study found that patients with acne had poorer body composition, particularly smaller PhA, and lower adherence to the Mediterranean diet. The research also indicated that PhA and PREDIMED scores might serve as markers for the severity of acne.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
C. A. Gonzalez-Correa, S. A. Jaimes, J. Cardenas-Jimenez
Summary: This study tests a geometrical parameterization method for Electrical Bio-Impedance Spectroscopy (EBIS) readings and compares it with other methods. The results show that the method performs well with low noise levels but poorly with high noise levels.
SCIENTIFIC REPORTS
(2022)
Review
Nutrition & Dietetics
Mariana Garcia Branco, Carlota Mateus, Manuel Luis Capelas, Nuno Pimenta, Teresa Santos, Antti Makitie, Susana Ganhao-Arranhado, Carolina Trabulo, Paula Ravasco
Summary: This scoping review evaluates the scientific and clinical evidence on the use of BIA for body composition assessment in oncology patients. The findings suggest that BIA is a suitable and valid method for body composition assessment in cancer patients and has potential clinical value in preoperative risk evaluation, reducing postoperative complications and hospital stay, and predicting prognosis.
Article
Nutrition & Dietetics
Sylvia Ryz, Larissa Nixdorf, Juergen Puchinger, Andrea Lassnigg, Dominik Wiedemann, Martin H. Bernardi
Summary: This study showed that PhA in cardiac surgery patients decreased postoperatively, with patients with lower preoperative PhA being older, frailer, and having longer ICU stays. Preoperative PhA was influenced by frailty and cardiac function, while postoperative PhA decline was influenced by fluid balances and cardiopulmonary bypass times. Perioperative PhA measurement is crucial for risk evaluation in cardiac surgery patients.
Article
Geriatrics & Gerontology
Yasunori Akamatsu, Toru Kusakabe, Hiroshi Arai, Yuji Yamamoto, Kazuwa Nakao, Kentaro Ikeue, Yuki Ishihara, Tetsuya Tagami, Akihiro Yasoda, Kojiro Ishii, Noriko Satoh-Asahara
Summary: This study examined the relationship between phase angle (PhA) and muscle quality, as well as other body composition parameters. It found that age, skeletal muscle mass index (SMI), and muscle quality were independently associated with PhA. PhA demonstrated good predictive ability for sarcopenia, indicating its potential as an easily measurable index for muscle quality assessment and sarcopenia diagnosis.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Nutrition & Dietetics
Sandra Unterberger, Rudolf Aschauer, Patrick A. Zoehrer, Agnes Draxler, Mirjam Aschauer, Benno Kager, Bernhard Franzke, Eva-Maria Strasser, Karl-Heinz Wagner, Barbara Wessner
Summary: In recent years, the phase angle (PhA) has been studied as a variable to assess cell integrity and physical performance. However, there is limited data on healthy older adults. This retrospective analysis examined the relationship between PhA, body composition, physical performance, and macronutrient intake in older adults and found that PhA was associated with physical performance but not protein intake. Age, sex, BMI, and PhA were predictors of performance test outcomes.
Article
Geriatrics & Gerontology
S. J. Ko, J. Cho, S. M. Choi, Y. S. Park, C. -H. Lee, S. -M. Lee, C. -G. Yoo, Y. W. Kim, J. Lee
Summary: The study revealed that high PhA above 3.5 was associated with lower in-hospital mortality and a shorter duration of ICU stay, while frailty was associated with more mechanical ventilation days.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Nutrition & Dietetics
Fabricio Moreira Reis, Maryanne Zilli Canedo da Silva, Nayrana Soares do Carmo Reis, Fabiana Lourenco Costa, Caroline Ferreira da Silva Mazeto Pupo da Silveira, Pasqual Barretti, Luis Cuadrado Martin, Silmeia Garcia Zanati Bazan
Summary: This study aimed to investigate the association between phase angle and coronary artery calcium score in patients on peritoneal dialysis. The results showed a significant association between the two variables. Phase angle may serve as a risk marker for coronary artery disease in this population.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Analytical
Fang-Lin Jiang, Saizhao Tang, Seon-Ho Eom, Jae-Young Lee, Ji Heon Chae, Chul-Hyun Kim
Summary: This study aimed to validate the use of bioelectrical impedance vector analysis (BIVA) in evaluating sarcopenia in elderly individuals and to examine the relationship between phase angle (PhA), physical performance, and muscle mass. The results showed significant differences in BIVA between sarcopenia and non-sarcopenia groups in both sexes. PhA was found to be significantly correlated with age, appendicular skeletal muscle (ASM), handgrip strength (HGS), muscle quality, and physical performance. Therefore, BIVA can be used as a practical assessment method for diagnosing sarcopenia in elderly individuals with reduced mobility.
Article
Gastroenterology & Hepatology
Ana Maria Gomez-Perez, Patricia Ruiz-Limon, Jordi Salas-Salvado, Jesus Vioque, Dolores Corella, Montse Fito, Josep Vidal, Alessandro Atzeni, Laura Torres-Collado, Andrea Alvarez-Sala, Maria Angeles Martinez, Albert Goday, David Benaiges, Jesus Garcia-Gavilan, Maria Rosa Bernal Lopez, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: This study found that the Mediterranean diet and physical activity can change the scores for liver steatosis and liver fibrosis within one year, and these changes are related to changes in gut microbiota. The findings are important for identifying microbiota-based biomarkers for NAFLD and developing strategies to modulate gut microbiota in the treatment of NAFLD.
Review
Nutrition & Dietetics
Julia Lima, Igor Eckert, Maria Cristina Gonzalez, Flavia Moraes Silva
Summary: This meta-analysis found that low PhA was associated with higher mortality and longer ICU length of stay, while overhydration identified by BIVA was not a predictor of death in critically ill patients, with limited evidence.
CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Luo Fu, Zhengyun Ren, Xiaoxiao Liu, Nianwei Wu, Kang Zhao, Guangping Luo, Huawu Yang, Yuanchuan Zhang, Tong Yan, Yanjun Liu, Tongtong Zhang
Summary: Phase angle (PhA), as a ratio of reactance and resistance, is an indicator of cellular health and muscle quality. However, the lack of reference values for Chinese overweight and obese populations limits the usefulness of PhA in clinical practice. This study provides PhA reference data in different age and BMI groups by sex and investigates the associations of age, sex, and BMI with PhA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Ayaka Matsumoto, Sayuri Shimazu, Ai Shiraishi, Yoshifumi Kido, Takahiro Bise, Kota Hori, Koki Yoneda
Summary: This study examined the association between bioimpedance analysis derived phase angle and sarcopenic obesity. The results showed a negative correlation between phase angle and sarcopenic obesity, and cutoff values of the phase angle were found to be predictive for sarcopenic obesity.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Isabel Cornejo-Pareja, Isabel M. Vegas-Aguilar, Jose Manuel Garcia-Almeida, Diego Bellido-Guerrero, Antonio Talluri, Henry Lukaski, Francisco J. Tinahones
Summary: The study found that non-surviving COVID-19 patients had significantly lower PhA and SPhA values, as well as increased hydration. In COVID-19 patients, low PhA (<3.95 degrees) was identified as a significant predictor of mortality risk.
CLINICAL NUTRITION
(2022)
Review
Medicine, General & Internal
Wen-He Zheng, Yi-He Zhao, Yan Yao, Hui-Bin Huang
Summary: This systematic review and meta-analysis found that bioelectrical impedance-derived phase angle (PA) has good prognostic value in critically ill patients. Low PA values are associated with higher mortality risk, and this result is confirmed in subgroup and sensitivity analyses.
FRONTIERS IN MEDICINE
(2023)
Correction
Endocrinology & Metabolism
R. M. Ruggeri, E. Benevento, F. De Cicco, B. Fazzalari, E. Guadagno, I. Hasballa, M. G. Tarsitano, A. M. Isidori, A. Colao, A. Faggiano, I Aini, I Aini, M. Albertelli, Y. Alessi, B. Altieri, S. Antonini, L. Barrea, F. Birtolo, F. Campolo, G. Cannavale, C. Cantone, S. Carra, R. Centello, A. Cozzolino, S. Molfetta, V. Vito, G. Fanciulli, T. Feola, F. Ferrau, S. Gay, E. Giannetta, F. Grillo, E. Grossrubatscher, V Guarnotta, A. Salvia, A. Laffi, A. Lania, A. Liccardi, P. Malandrino, R. Mazzilli, E. Messina, N. Mikovic, R. Minotta, R. Modica, G. Muscogiuri, C. Pandozzi, G. Pugliese, G. Puliani, A. Ragni, M. Rubino, F. Russo, F. Sesti, L. Verde, A. Veresani, C. Vetrani, G. Vitale, V Zamponi, I Zanata
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
R. M. Ruggeri, E. Benevento, F. De Cicco, B. Fazzalari, E. Guadagno, I Hasballa, M. G. Tarsitano, A. M. Isidori, A. Colao, A. Faggiano
Summary: This review reevaluates the genetic basis and clinical features of gastroenteropancreatic and thoracic neuroendocrine tumors (NETs) in the context of inherited syndromes, with a special focus on molecularly targeted therapies. Significant advances have been made in understanding the genetic and epigenetic mechanisms of NET development, leading to the identification of targetable alterations and the development of novel targeted therapies.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Ludovica Verde, Maria Dalamaga, Xavier Capo, Giuseppe Annunziata, Maria Hassapidou, Annamaria Docimo, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri, Luigi Barrea
Summary: High adherence to the Mediterranean diet (MD) leads to better results in the very low-calorie ketogenic diet (VLCKD), possibly due to the antioxidant and anti-inflammatory properties of the MD, which create a metabolic state favorable for more effective ketosis.
Review
Nutrition & Dietetics
Luigi Barrea, Ludovica Verde, Renata Simona Auriemma, Claudia Vetrani, Mauro Cataldi, Evelyn Frias-Toral, Gabriella Pugliese, Elisabetta Camajani, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: The aim of this review is to provide an overview of the menopause-related changes in microbiota and their role in the pathogenesis of menopause-related diseases. In addition, evidence on probiotic supplementation as a therapeutic strategy is discussed. Menopause is associated with dysbiosis, and these changes in the composition of microbiota in different sites (gut, vaginal, and oral microbiota) might play a role in the pathogenesis of menopause-related diseases such as osteoporosis, breast cancer, endometrial hyperplasia, periodontitis, and cardiometabolic diseases.
CURRENT NUTRITION REPORTS
(2023)
Review
Food Science & Technology
Luigi Barrea, Sara Cacciapuoti, Matteo Megna, Ludovica Verde, Claudio Marasca, Rosa Vono, Elisabetta Camajani, Annamaria Colao, Silvia Savastano, Gabriella Fabbrocini, Giovanna Muscogiuri
Summary: Acne is an inflammatory disease caused by hormonal changes and bacterial infection. The influence of diet on acne is a growing topic, but the research findings have been contradictory. Very low-calorie ketogenic diet (VLCKD), which has been associated with weight loss and reduced inflammation, has the potential to benefit acne treatment. This review aims to provide evidence from scientific literature to support the use of VLCKD in acne treatment.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Luigi Barrea, Ludovica Verde, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: Oxidative stress is a key factor in the development of NAFLD and obesity, leading to mitochondrial dysfunction and inflammation. The Mediterranean Diet, with its antioxidant properties, is recommended as a preferred nutritional approach in the treatment of NAFLD. Adherence to the Mediterranean Diet can lower the risk of developing NAFLD.
Review
Biochemistry & Molecular Biology
Luigi Barrea, Claudia Vetrani, Ludovica Verde, Evelyn Frias-Toral, Florencia Ceriani, Simona Cernea, Annamaria Docimo, Chiara Graziadio, Devjit Tripathy, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: Diet is crucial in the pathogenesis of T2DM. Individualized medical nutritional therapy has been shown to improve outcomes, and various eating patterns have proven benefits for T2DM patients. Personalized meal plans should be considered, with reduced carbohydrate intake and replacement of high GI foods. The quality of fats is important, and supplementation with antioxidants or micronutrients is not recommended.
Review
Endocrinology & Metabolism
Ludovica Verde, Stefania Luca, Simona Cernea, Cem Sulu, Volkan Demirhan Yumuk, Trond Geir Jenssen, Silvia Savastano, Gerardo Sarno, Annamaria Colao, Luigi Barrea, Giovanna Muscogiuri
Summary: The purpose of this review is to summarize the current evidence on the role of obesity in the development and progression of chronic kidney disease and the current evidence on nutritional, pharmacological, and surgical strategies for the management of individuals with obesity and chronic kidney disease. Obesity can harm the kidney through direct pathways and systemic complications, leading to glomerular hyperfiltration, proteinuria, and impaired glomerular filtration rate. Various weight loss strategies exist, but there are no clinical practice guidelines for managing obesity and chronic kidney disease.
CURRENT OBESITY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Giulia de Alteriis, Gabriella Pugliese, Antonella Di Sarno, Giovanna Muscogiuri, Luigi Barrea, Valentina Cossiga, Giuseppe Perruolo, Michele Francesco Di Tolla, Francesca Zumbolo, Pietro Formisano, Filomena Morisco, Silvia Savastano
Summary: Visceral obesity is associated with the progression of NASH. CK18 epitopes M30 and M65 are accurate markers for detecting NASH. This study found that CK18M30 and CK18M65 levels were significantly correlated with anthropometric and metabolic characteristics, liver stiffness, and indices of steatosis and fibrosis in subjects with visceral obesity. These levels could serve as good biomarkers for early identification of NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Luigi Barrea, Ludovica Verde, Daniel Simancas-Racines, Ana Karina Zambrano, Evelyn Frias-Toral, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri
Summary: The study found that high adherence to the Mediterranean diet was associated with the metabolically healthy obesity (MHO) phenotype. Additionally, it was suggested that a specific cut-off of the PREDIMED score could be used to differentiate patients with MUO/MHO phenotypes, helping to identify those at higher cardiovascular risk who may require specific dietary interventions.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Editorial Material
Nutrition & Dietetics
Mikiko Watanabe, Silvia Savastano, Carla Lubrano, Giovanni Spera
Review
Endocrinology & Metabolism
G. Muscogiuri, L. Verde, C. Vetrani, L. Barrea, S. Savastano, A. Colao
Summary: There are gender differences in obesity prevalence and phenotype, body fat distribution, drug efficacy, clinical trial representation, and different secondary effects of bariatric surgery. Gender is an important variable in obesity analysis.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
L. Barrea, L. Verde, G. Annunziata, E. Camajani, M. Caprio, A. S. Sojat, L. V. Marina, V. Guarnotta, A. Colao, G. Muscogiuri
Summary: This review examines the potential role of the Mediterranean diet (MD) in the prevention and management of endocrine disorders. The studies reviewed suggest that MD may have a beneficial effect in various endocrine disorders due to its anti-inflammatory and antioxidant properties, as well as its high levels of phytochemicals.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)