Structural basis of the specificity of USP18 toward ISG15

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

(2016) Marije E.C. Meuwissen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

(2016) Miklós Békés et al.   MOLECULAR CELL

ISG15 deficiency and increased viral resistance in humans but not mice

(2016) Scott D. Speer et al.   Nature Communications

ISG15 uncut: Dissecting enzymatic and non-enzymatic functions of USP18 in vivo

(2015) Lars Ketscher et al.   CYTOKINE

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

(2015) Lars Ketscher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms

(2015) Zhifen Yang et al.   Scientific Reports

Ubiquitin-Like Protein ISG15 (Interferon-Stimulated Gene of 15 kDa) in Host Defense Against Heart Failure in a Mouse Model of Virus-Induced Cardiomyopathy

(2014) Anna Rahnefeld et al.   CIRCULATION

Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15

(2014) Anja Basters et al.   FEBS Journal

Modification of PCNA by ISG15 Plays a Crucial Role in Termination of Error-Prone Translesion DNA Synthesis

(2014) Jung Mi Park et al.   MOLECULAR CELL

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

(2014) Heidi J A Wallweber et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DUSP–Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange

(2014) Marcello Clerici et al.   Nature Communications

ARF and p53 Coordinate Tumor Suppression of an Oncogenic IFN-β-STAT1-ISG15 Signaling Axis

(2014) Jason T. Forys et al.   Cell Reports

Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease

(2014) Kiira Ratia et al.   PLoS Pathogens

A 2.2 Å resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding

(2014) Katrina Molland et al.   Acta Crystallographica Section F-Structural Biology Communications

USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1–TAB1 complex

(2013) Xikui Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Antiviral Activities of ISG15

(2013) David J. Morales et al.   JOURNAL OF MOLECULAR BIOLOGY

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

(2013) Reggy Ekkebus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Strategy for Modulation of Enzymes in the Ubiquitin System

(2013) A. Ernst et al.   SCIENCE

Interferon-induced ISG15 pathway: an ongoing virus–host battle

(2013) Chen Zhao et al.   TRENDS IN MICROBIOLOGY

Two ZnF-UBP Domains in Isopeptidase T (USP5)

(2012) George V. Avvakumov et al.   BIOCHEMISTRY

IFNs, ISGylation and cancer: Cui prodest?

(2012) Andrea Sgorbissa et al.   CYTOKINE & GROWTH FACTOR REVIEWS

HERC6 Is the Main E3 Ligase for Global ISG15 Conjugation in Mouse Cells

(2012) Diede Oudshoorn et al.   PLoS One

Mycobacterial Disease and Impaired IFN-  Immunity in Humans with Inherited ISG15 Deficiency

(2012) D. Bogunovic et al.   SCIENCE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

mHERC6 is the essential ISG15 E3 ligase in the murine system

(2011) Lars Ketscher et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21

(2011) Yu Ye et al.   EMBO REPORTS

Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry

(2011) XiaoDong Huang et al.   MOLECULAR CELL

Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-like Domain and Allosteric Regulation by GMP-Synthetase

(2011) Alex C. Faesen et al.   MOLECULAR CELL

MultiBac: expanding the research toolbox for multiprotein complexes

(2011) Christoph Bieniossek et al.   TRENDS IN BIOCHEMICAL SCIENCES

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin

(2010) Farid El Oualid et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emerging Role of ISG15 in Antiviral Immunity

(2010) Brian Skaug et al.   CELL

Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification

(2010) H. X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

(2010) Larissa A. Durfee et al.   MOLECULAR CELL

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Automated unrestricted multigene recombineering for multiprotein complex production

(2009) Christoph Bieniossek et al.   NATURE METHODS

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Mitochondrial Morphology by USP30, a Deubiquitinating Enzyme Present in the Mitochondrial Outer Membrane

(2008) Nobuhiro Nakamura et al.   MOLECULAR BIOLOGY OF THE CELL