Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin

VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells

(2014) Tilman Schneider-Hohendorf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Multiple Sclerosis-Like Lesions Induced by Effector CD8 T Cells Recognizing a Sequestered Antigen on Oligodendrocytes

(2014) A. Saxena et al.   JOURNAL OF IMMUNOLOGY

α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets

(2014) Veit Rothhammer et al.   Acta Neuropathologica Communications

Antagonizing the  4 1 Integrin, but Not  4 7, Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis

(2013) K. G. Haanstra et al.   JOURNAL OF IMMUNOLOGY

L-Selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients

(2013) N. Schwab et al.   NEUROLOGY

Natalizumab affects the T-cell receptor repertoire in patients with multiple sclerosis

(2013) C. Warnke et al.   NEUROLOGY

In situ evidence of JC virus control by CD8+ T cells in PML-IRIS during HIV infection

(2013) G. Martin-Blondel et al.   NEUROLOGY

Neurons as targets for T cells in the nervous system

(2013) Roland S. Liblau et al.   TRENDS IN NEUROSCIENCES

Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis

(2012) C. G. Bien et al.   BRAIN

Cutting Edge: Neuronal Recognition by CD8 T Cells Elicits Central Diabetes Insipidus

(2012) T. Scheikl et al.   JOURNAL OF IMMUNOLOGY

Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

(2012) Gary Bloomgren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Junctional Adhesion Molecule (JAM)-C Deficient C57BL/6 Mice Develop a Severe Hydrocephalus

(2012) Lena Wyss et al.   PLoS One

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Changes in JC Virus-Specific T Cell Responses during Natalizumab Treatment and in Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

(2012) Molly R. Perkins et al.   PLoS Pathogens

Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy

(2011) Imke Metz et al.   ACTA NEUROPATHOLOGICA

Pathogenesis of the immune reconstitution inflammatory syndrome affecting the central nervous system in patients infected with HIV

(2011) G. Martin-Blondel et al.   BRAIN

Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome

(2011) Lilian Aly et al.   BRAIN

Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on  4 integrin

(2011) I. Ifergan et al.   BRAIN

TET inducible expression of the α4β7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis

(2011) Axinia Döring et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis

(2011) A. Saxena et al.   FEBS LETTERS

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE

(2011) Veit Rothhammer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8+ T Cells Primed in the Periphery Provide Time-Bound Immune-Surveillance to the Central Nervous System

(2011) K. G. Young et al.   JOURNAL OF IMMUNOLOGY

Immune reconstitution inflammatory syndrome in natalizumab-associated PML

(2011) I. L. Tan et al.   NEUROLOGY

Trafficking of immune cells in the central nervous system

(2010) Emma H. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-Brain Barrier Endothelium

(2010) O. Steiner et al.   JOURNAL OF IMMUNOLOGY

Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with α4β1 integrin

(2009) Ralf J. Ludwig et al.   IMMUNOLOGY

α4 Integrin/FN-CS1 mediated leukocyte adhesion to brain microvascular endothelial cells under flow conditions

(2009) Shumei Man et al.   JOURNAL OF NEUROIMMUNOLOGY

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

β1integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity

(2009) Martina Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decrease in the Numbers of Dendritic Cells and CD4+ T Cells in Cerebral Perivascular Spaces Due to Natalizumab

(2008) Maria del Pilar Martin   ARCHIVES OF NEUROLOGY

Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab

(2008) H. Bonig et al.   BLOOD