Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains

(2016) Judith Lind et al.   BMC MICROBIOLOGY

The Role of CagA in the Gastric Biology of Helicobacter pylori

(2016) Steffen Backert et al.   CANCER RESEARCH

HtrA-mediated E-cadherin cleavage is limited to DegP and DegQ homologs expressed by gram-negative pathogens

(2016) Carmen M. Abfalter et al.   Cell Communication and Signaling

HtrA, a Temperature- and Stationary Phase-Activated Protease Involved in Maturation of a Key Microbial Virulence Determinant, Facilitates Borrelia burgdorferi Infection in Mammalian Hosts

(2016) Meiping Ye et al.   INFECTION AND IMMUNITY

The integrin adhesome network at a glance

(2016) Edward R. Horton et al.   JOURNAL OF CELL SCIENCE

Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA

(2016) Thomas P. Schmidt et al.   Scientific Reports

Composition, structure and function of theHelicobacter pylori cagpathogenicity island encoded type IV secretion system

(2015) Steffen Backert et al.   Future Microbiology

Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA

(2015) Nicole Tegtmeyer et al.   MOLECULAR MICROBIOLOGY

A Specific A/T Polymorphism in Western Tyrosine Phosphorylation B-Motifs Regulates Helicobacter pylori CagA Epithelial Cell Interactions

(2015) Xue-Song Zhang et al.   PLoS Pathogens

Helicobacter pylori-induced posttranscriptional regulation of H-K-ATPase α-subunit gene expression by miRNA

(2014) Yong-Mei Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis

(2014) Masanori Hatakeyama   Cell Host & Microbe

Helicobacter pylori cell translocating kinase (CtkA/JHP0940) is pro-apoptotic in mouse macrophages and acts as auto-phosphorylating tyrosine kinase

(2014) Shivendra Tenguria et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Helicobacter pylori CagL Y58/E59 Mutation Turns-Off Type IV Secretion-Dependent Delivery of CagA into Host Cells

(2014) Nicole Tegtmeyer et al.   PLoS One

Systematic Analysis of Phosphotyrosine Antibodies Recognizing Single Phosphorylated EPIYA-Motifs in CagA of Western-Type Helicobacter pylori Strains

(2014) Judith Lind et al.   PLoS One

Helicobacter pylorigamma-glutamyl transpeptidase and its pathogenic role

(2014) Vittorio Ricci   WORLD JOURNAL OF GASTROENTEROLOGY

The impact of serine protease HtrA in apoptosis, intestinal immune responses and extra-intestinal histopathology during Campylobacter jejuni infection of infant mice

(2014) Markus M Heimesaat et al.   Gut Pathogens

The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice

(2014) Markus M. Heimesaat et al.   Frontiers in Cellular and Infection Microbiology

The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis

(2013) Gernot Posselt et al.   Cell Communication and Signaling

Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both?

(2013) Steffen Backert et al.   Cell Communication and Signaling

Helicobacter pyloridownregulates expression of human β-defensin 1 in the gastric mucosa in a type IV secretion-dependent fashion

(2013) S. R. Patel et al.   CELLULAR MICROBIOLOGY

The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production inHelicobacter pyloriinfected dendritic cells

(2013) Dong-Jae Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal toChlamydia trachomatis

(2013) Sarina Gloeckl et al.   MOLECULAR MICROBIOLOGY

Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori

(2013) Nina R. Salama et al.   NATURE REVIEWS MICROBIOLOGY

Electron Microscopic, Genetic and Protein Expression Analyses of Helicobacter acinonychis Strains from a Bengal Tiger

(2013) Nicole Tegtmeyer et al.   PLoS One

A Helical RGD Motif Promoting Cell Adhesion: Crystal Structures of the Helicobacter pylori Type IV Secretion System Pilus Protein CagL

(2013) Stephan Barden et al.   STRUCTURE

Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori

(2012) Steffen Backert et al.   Cell Communication and Signaling

Helicobacter pyloriCagL dependent induction of gastrin expression via a novel αvβ5-integrin–integrin linked kinase signalling complex

(2012) Tobias Wiedemann et al.   GUT

Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin

(2012) Benjamin Hoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains

(2012) Doreen Mueller et al.   JOURNAL OF CLINICAL INVESTIGATION

Live Helicobacter pylori in the root canal of endodontic-infected deciduous teeth

(2012) Christian Hirsch et al.   JOURNAL OF GASTROENTEROLOGY

Peptidoglycan maturation enzymes affect flagellar functionality in bacteria

(2012) Sophie Roure et al.   MOLECULAR MICROBIOLOGY

Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin

(2012) Manja Boehm et al.   Gut Pathogens

An RGD Helper Sequence in CagL of Helicobacter pylori Assists in Interactions with Integrins and Injection of CagA

(2012) Jens Conradi et al.   Frontiers in Cellular and Infection Microbiology

Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins αVβ3 and α5β1

(2011) Jens Conradi et al.   AMINO ACIDS

Serine Phosphorylation of Cortactin Controls Focal Adhesion Kinase Activity and Cell Scattering Induced by Helicobacter pylori

(2011) Nicole Tegtmeyer et al.   Cell Host & Microbe

Induction of TLR-2 and TLR-5 Expression by Helicobacter pylori Switches cagPAI-Dependent Signalling Leading to the Secretion of IL-8 and TNF-α

(2011) Suneesh Kumar Pachathundikandi et al.   PLoS One

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

(2010) Benjamin Hoy et al.   EMBO REPORTS

Helicobacter pylori CagL Activates ADAM17 to Induce Repression of the Gastric H, K-ATPase α Subunit

(2010) Arindam Saha et al.   GASTROENTEROLOGY

What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori

(2010) Steffen Backert et al.   TRENDS IN MICROBIOLOGY

Proteases in bacterial pathogenesis

(2009) Hanne Ingmer et al.   RESEARCH IN MICROBIOLOGY

Helicobacter pylori Type IV Secretion Apparatus Exploits β1 Integrin in a Novel RGD-Independent Manner

(2009) Luisa F. Jiménez-Soto et al.   PLoS Pathogens

Development of Inducible Systems To Engineer Conditional Mutants of Essential Genes of Helicobacter pylori

(2008) I. G. Boneca et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Prediction of Extracellular Proteases of the Human Pathogen Helicobacter pylori Reveals Proteolytic Activity of the Hp1018/19 Protein HtrA

(2008) Martin Löwer et al.   PLoS One

Emerging roles of Abl family tyrosine kinases in microbial pathogenesis

(2008) Steffen Backert et al.   TRENDS IN BIOCHEMICAL SCIENCES