期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 10, 期 5, 页码 732-738出版社
ELSEVIER
DOI: 10.1016/j.arabjc.2014.07.002
关键词
ZnL complex; Antioxidant; Antibacterial; Kinetic studies
The evaluation of the antioxidant, antibacterial and enzyme inhibition effects of N2O2 Schiff base Zn complex was investigated. The percentage scavenging activity of hydroxyl radical (IC50-0.21 mu g), ABTS (IC50-0.19 mu g) and DPPH (IC50-0.25 mu g) shows that ZnL complex had a potential antioxidant activity. The antibacterial activity of ZnL complex was evaluated. Results showed that MIC value against Staphylococcus aureus and Salmonella typhi was 100 and 200 mu g/ml, respectively. ZnL complex showed strong inhibition toward alpha-amylase and alpha-glucosidase with an IC50 value of 0.18 and 0.23 mu g, respectively. The inhibition mechanism was analyzed with LB and Dixon plots. The ZnL complex could be a mixed noncompetitive and noncompetitive inhibitor with K-i values of 77.8 and 31.6 mu g for alpha-amylase and alpha-glucosidase, respectively. The preliminary assessment of ZnL complex showed that they can be used as an antioxidant, antibacterial and antidiabetic agents. (C) 2014 King Saud University. Production and hosting by Elsevier B.V.
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