期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 10, 期 -, 页码 S757-S764出版社
ELSEVIER
DOI: 10.1016/j.arabjc.2012.12.001
关键词
3,4-Dihydropyrimidin-2(1H)-ones; MCM-41; Ammonium dihydrogen phosphate
A green and efficient method is described for the solvent free synthesis of 3,4-dihydropyrimidin-2(1H)-ones through one-pot three-component condensation of ethyl acetoacetate, an aryl aldehyde, and urea using mesoporous MCM-41 supported ammonium dihydrogen phosphate (NH4H2PO4/MCM-41) as catalyst. The present methodology offers several advantages such as high yields, relatively short reaction times, mild reaction condition, easy work up, and using a highly recyclable catalyst. Some mechanistic studies revealed that the reaction would be achieved via formation of an acyliminium ion, followed by an acid-catalyzed cyclodehydration step. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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