Identification and characterization of two functional variants in the human longevity gene FOXO3

Cohort Profile: The 1895, 1905, 1910 and 1915 Danish Birth Cohort Studies - secular trends in the health and functioning of the very old

(2017) Signe Høi Rasmussen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

(2016) Alexander Teumer et al.   AGING CELL

Characterization of the direct targets of FOXO transcription factors throughout evolution

(2016) Ashley E. Webb et al.   AGING CELL

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Survival Prognosis in Very Old Adults

(2016) Mikael Thinggaard et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

The life-extending effect of dietary restriction requires Foxo3 in mice

(2015) Isao Shimokawa et al.   AGING CELL

FOXO3: A Major Gene for Human Longevity - A Mini-Review

(2015) Brian J. Morris et al.   GERONTOLOGY

Genome-wide patterns of selection in 230 ancient Eurasians

(2015) Iain Mathieson et al.   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

The transcriptional landscape of age in human peripheral blood

(2015) Marjolein J. Peters et al.   Nature Communications

Whole genome and exome sequencing of monozygotic twins discordant for Crohn’s disease

(2014) Britt-Sabina Petersen et al.   BMC GENOMICS

GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy

(2014) Linda Broer et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

MutationTaster2: mutation prediction for the deep-sequencing age

(2014) Jana Marie Schwarz et al.   NATURE METHODS

SIRT6 Minor Allele Genotype Is Associated with >5-Year Decrease in Lifespan in an Aged Cohort

(2014) Mindi J. TenNapel et al.   PLoS One

c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells

(2014) C Geismann et al.   Cell Death & Disease

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

dbPSHP: a database of recent positive selection across human populations

(2013) Mulin Jun Li et al.   NUCLEIC ACIDS RESEARCH

Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B

(2012) Friederike Flachsbart et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

FOXO3 Gene Variants and Human Aging: Coding Variants May Not Be Key Players

(2012) T. A. Donlon et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

From next-generation sequencing alignments to accurate comparison and validation of single-nucleotide variants: the pibase software

(2012) Michael Forster et al.   NUCLEIC ACIDS RESEARCH

CTCFBSDB 2.0: a database for CTCF-binding sites and genome organization

(2012) Jesse D. Ziebarth et al.   NUCLEIC ACIDS RESEARCH

The Danish Twin Registry: Linking Surveys, National Registers, and Biological Information

(2012) Axel Skytthe et al.   Twin Research and Human Genetics

A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3

(2011) Robert C. Kaplan et al.   HUMAN MOLECULAR GENETICS

A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals

(2011) Almut Nebel et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Transcription factor binding predictions using TRAP for the analysis of ChIP-seq data and regulatory SNPs

(2011) Morgane Thomas-Chollier et al.   Nature Protocols

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

(2011) L. D. Ward et al.   NUCLEIC ACIDS RESEARCH

Over-stimulation of insulin/IGF-1 signaling by western diet may promote diseases of civilization: lessons learnt from laron syndrome

(2011) Bodo C Melnik et al.   Nutrition & Metabolism

Genotype Imputation with Thousands of Genomes

(2011) Bryan Howie et al.   G3-Genes Genomes Genetics

Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data

(2010) Mette Soerensen et al.   AGING CELL

Flavonoid binding to human serum albumin

(2010) Alessandro Bolli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region

(2010) Espen Melum et al.   HUMAN MUTATION

TheFOXO3Ars2802292 G-Allele Associates with Improved Peripheral and Hepatic Insulin Sensitivity and Increased Skeletal Muscle-FOXO3AmRNA Expression in Twins

(2010) Karina Banasik et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

(2009) Ludmila Pawlikowska et al.   AGING CELL

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice

(2009) Kai Sun et al.   HEPATOLOGY

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

(2008) A. D. Johnson et al.   BIOINFORMATICS

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins

(2008) Kenneth Maiese et al.   TRENDS IN MOLECULAR MEDICINE